2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Caspase PARP Bcl-2 Family
  4. Anticancer agent 201

Anticancer agent 201 (Compound 2f) has IC50 values in the low micromolar range for multiple tumor cell lines. Anticancer agent 201 is highly cytotoxic to CCRF-CEM cells in vitro, inducing apotosis by activating caspase-3 in the intrinsic mitochondrial pathway and lysis of PARP, as well as reducing the expression of Bcl-2 and Bcl-XL proteins. Anticancer agent 201 can be used in cancer research.

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Anticancer agent 201 Chemical Structure

Anticancer agent 201 Chemical Structure

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Anticancer agent 201 Related Antibodies

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Description

Anticancer agent 201 (Compound 2f) has IC50 values in the low micromolar range for multiple tumor cell lines. Anticancer agent 201 is highly cytotoxic to CCRF-CEM cells in vitro, inducing apotosis by activating caspase-3 in the intrinsic mitochondrial pathway and lysis of PARP, as well as reducing the expression of Bcl-2 and Bcl-XL proteins. Anticancer agent 201 can be used in cancer research[1].

IC50 & Target

Caspase-3

 

Bcl-2

 

Bcl-xL

 

In Vitro

Anticancer agent 201 (Compound 2f) (3.5 μM, 17.5 μM; 24h) significantly induces cytotoxic reactions, increases the number of apoptotic cells, and leads to a dose-dependent reduction of mitochondrial membrane potential in CCRF-CEM cells[1].
Anticancer agent 201 (3.5 μM, 17.5 μM; 24h) blocks or slows down the G0/G1 phase cell cycle in CCRF-CEM cells, reduces the proportion of S-phase cells, and inhibits RNA synthesis[1].

Cytotoxic activities of Anticancer agent 201 against eight tumor (including multidrug resistant variants) and two normal fibroblast cell lines[1]

Cell lines CCRF-CEM CEM-DNR K562 K562-TAX A549 HCT116 HCT116p53-/- U20S BJ MRC-5
IC50 (μM) 3.5 4.9 23 17 11 10 18 19 ＞50 27

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 201 Related Antibodies

Apoptosis Analysis[1]

Cell Line: CCRF-CEM cancer cell line
Concentration: 3.5 μM, 17.5 μM
Incubation Time: 24h
Result: Induced the strongest cytotoxic reaction and the number of apoptotic cells increased significantly.
Resulted in a significant decrease in mitochondrial membrane potential of CCRF-CEM cells in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: CCRF-CEM cancer cell line
Concentration: 3.5 μM, 17.5 μM
Incubation Time: 24h
Result: Caused the cell cycle to be blocked or slowed down in the G0/G1 phase, while the proportion of S phase cells decreases.
At 17.5 μM, the mitosis rate of the cells decreased.
At 3.5 μM increased the proportion of BRDU-positive cells.
At 17.5μM, the proportion of BRDU-positive cells decreased.
At 17.5μM, RNA synthesis almost completely stopped.

Western Blot Analysis[1]

Cell Line: CCRF-CEM cancer cell line
Concentration: 3.5 μM, 17.5 μM
Incubation Time: 24h
Result: Leaded to decreased expression of both Bcl-2 and Bcl-XL.
At 17.5μM, caused the activation of caspase-3 and the cleavage of PARP.
Molecular Weight

578.75

Formula

C34H49F3O4
SMILES

O=C1C=C(C2C[C@]3([C@@](C(C)(C2O1)C)([H])CC[C@@]4([C@]3([H])CC[C@]5([H])[C@@]6([H])[C@@H](CC[C@@]6(CC[C@]54C)C(O)=O)C(C)C)C)C)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 201 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 201Anticancer agent201Anticancer agent-201ApoptosisCaspasePARPBcl-2 Familypoly ADP ribose polymeraseTriterpenoid PyroneCytotoxicityMitochondriaCCRF-CEMInhibitorinhibitorinhibit

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