Ar-V7-IN-1

Name: Ar-V7-IN-1
Brand: MedChemExpress
SKU: HY-145709
Rating: 4.5 (1 reviews)

Cat. No.: HY-145709 Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Ar-V7-IN-1 is a potent inhibitor of Ar-V7. AR-V7 is a hormone-independent splice variant of the androgen receptor. Ar-V7-IN-1 has the potential for the research of various indications, in particular cancers such as prostate cancer (extracted from patent WO2018114781A1, compound 43).

For research use only. We do not sell to patients.

Ar-V7-IN-1 Chemical Structure

CAS No. : 2230880-25-6

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 286	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 286	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1280	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2100	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	IC₅₀	0.1 μM Compound: 25	Inhibition of androgen receptor transcriptional activity in human LNCaP cells after 3 days by eGFP assay Inhibition of androgen receptor transcriptional activity in human LNCaP cells after 3 days by eGFP assay	[PMID: 25062331]
LNCaP	IC₅₀	0.17 μM Compound: 25	Inhibition of androgen receptor in human LNCaP cells assessed as inhibition of prostate-specific antigen secretion into media after 3 days Inhibition of androgen receptor in human LNCaP cells assessed as inhibition of prostate-specific antigen secretion into media after 3 days	[PMID: 25062331]

Molecular Weight

394.09

Formula

C₁₀H₁₀Br₂N₄OS

CAS No.

2230880-25-6

Appearance

Solid

Color

White to off-white

SMILES

BrC1=C(Br)N(C2=CSC(N3CCOCC3)=N2)C=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (211.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5375 mL	12.6875 mL	25.3749 mL
5 mM	0.5075 mL	2.5375 mL	5.0750 mL
10 mM	0.2537 mL	1.2687 mL	2.5375 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) HNMR (256 KB) LCMS (267 KB)

Handling Instructions (2659 KB)

References

[1]. Fuqiang Ban, et al. Ar-v7 inhibitors. Patent WO2018114781A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5375 mL	12.6875 mL	25.3749 mL	63.4373 mL
	5 mM	0.5075 mL	2.5375 mL	5.0750 mL	12.6875 mL
	10 mM	0.2537 mL	1.2687 mL	2.5375 mL	6.3437 mL
	15 mM	0.1692 mL	0.8458 mL	1.6917 mL	4.2292 mL
	20 mM	0.1269 mL	0.6344 mL	1.2687 mL	3.1719 mL
	25 mM	0.1015 mL	0.5075 mL	1.0150 mL	2.5375 mL
	30 mM	0.0846 mL	0.4229 mL	0.8458 mL	2.1146 mL
	40 mM	0.0634 mL	0.3172 mL	0.6344 mL	1.5859 mL
	50 mM	0.0507 mL	0.2537 mL	0.5075 mL	1.2687 mL
	60 mM	0.0423 mL	0.2115 mL	0.4229 mL	1.0573 mL
	80 mM	0.0317 mL	0.1586 mL	0.3172 mL	0.7930 mL
	100 mM	0.0254 mL	0.1269 mL	0.2537 mL	0.6344 mL

Ar-V7-IN-1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ar-V7-IN-12230880-25-6Androgen ReceptorAr-V7hormone-independentandrogen receptorprostate cancerInhibitorinhibitorinhibit

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Ar-V7-IN-1

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Molarity Calculator

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Complete Stock Solution Preparation Table

Ar-V7-IN-1 Related Classifications

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