2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation MAPK/ERK Pathway
  3. Apoptosis Reactive Oxygen Species JNK Oxidative Phosphorylation
  4. BDE 47

BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish.

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BDE 47 Chemical Structure

BDE 47 Chemical Structure

CAS No. : 5436-43-1

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Based on 1 publication(s) in Google Scholar

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Description

BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish[1].

Molecular Weight

485.79

Formula

C12H6Br4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

BrC1=CC=C(C(Br)=C1)OC2=CC=C(C=C2Br)Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (411.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0585 mL 10.2925 mL 20.5850 mL
5 mM 0.4117 mL 2.0585 mL 4.1170 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0585 mL 10.2925 mL 20.5850 mL 51.4626 mL
5 mM 0.4117 mL 2.0585 mL 4.1170 mL 10.2925 mL
10 mM 0.2059 mL 1.0293 mL 2.0585 mL 5.1463 mL
15 mM 0.1372 mL 0.6862 mL 1.3723 mL 3.4308 mL
20 mM 0.1029 mL 0.5146 mL 1.0293 mL 2.5731 mL
25 mM 0.0823 mL 0.4117 mL 0.8234 mL 2.0585 mL
30 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7154 mL
40 mM 0.0515 mL 0.2573 mL 0.5146 mL 1.2866 mL
50 mM 0.0412 mL 0.2059 mL 0.4117 mL 1.0293 mL
60 mM 0.0343 mL 0.1715 mL 0.3431 mL 0.8577 mL
80 mM 0.0257 mL 0.1287 mL 0.2573 mL 0.6433 mL
100 mM 0.0206 mL 0.1029 mL 0.2059 mL 0.5146 mL
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BDE 47 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BDE 475436-43-1BDE47BDE-47ApoptosisReactive Oxygen SpeciesJNKOxidative Phosphorylationc-Jun N-terminal kinasezebrafishInhibitorinhibitorinhibit

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