2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor NF-κB Metabolic Enzyme/Protease
  3. Glucocorticoid Receptor Reactive Oxygen Species NO Synthase
  4. Beclometasone dipropionate monohydrate

Beclometasone dipropionate monohydrate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma .

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Beclometasone dipropionate monohydrate Chemical Structure

Beclometasone dipropionate monohydrate Chemical Structure

CAS No. : 77011-63-3

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Beclometasone dipropionate monohydrate Related Antibodies

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Description

Beclometasone dipropionate monohydrate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma [1][2].

IC50 & Target

iNOS

 

In Vitro

Beclometasone dipropionate monohydrate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Beclometasone dipropionate monohydrate Related Antibodies

Western Blot Analysis[2]

Cell Line: 16HBE cells
Concentration: 1, 10 and 100 nM
Incubation Time: 20 min
Result: Reduced the levels of iNOS, ROS and NT generated by rhIL-17A.
In Vivo

Beclometasone dipropionate monohydrate (150 µg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice with asthma[1]
Dosage: 150 µg/kg
Administration: Nebulization
Result: Decreased total cell number and relative eosinophil number in BALF.
Clinical Trial
Molecular Weight

539.06

Formula

C28H39ClO8
CAS No.
SMILES

CCC(OCC([C@@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@H](C2)O)([C@@]4(C(CC3)=CC(C=C4)=O)C)Cl)([H])C[C@@H]1C)C)OC(CC)=O)=O)=O.O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Beclometasone dipropionate monohydrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Beclometasone dipropionate77011-63-3Glucocorticoid ReceptorReactive Oxygen SpeciesNO SynthaseNitric oxide synthasesNOSSTAT-1iNOS16HBE cellsasthmainflammationInhibitorinhibitorinhibit

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