2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Bisoprolol

Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.

For research use only. We do not sell to patients.

Bisoprolol Chemical Structure

Bisoprolol Chemical Structure

CAS No. : 66722-44-9

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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Bisoprolol:

Bisoprolol Related Antibodies

Top Publications Citing Use of Products

    Bisoprolol purchased from MedChemExpress. Usage Cited in: Mol Neurobiol. 2019 Jan;56(1):367-377.  [Abstract]

    Inhibitory effect of bisoprolol fumarate on PrPSc accumulation in N2a-FK cells. After the cells are incubated in medium mixed with each concentration of sample compound or water (negative control) for 48 h, the collected cell lysates are digested with proteinase K. Western blotting is then performed for quantification of the PrPSc level.

    View All Adrenergic Receptor Isoform Specific Products:

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    α adrenergic receptor β adrenergic receptor

    • Biological Activity

    • Purity & Documentation

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    Description

    Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research[1][2].

    IC50 & Target[1]

    Beta-1 adrenergic receptor

     

    Cellular Effect
    Cell Line Type Value Description References
    A-375 IC50
    > 100 μM
    Compound: Bisoprolol
    Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
    Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
    		[PMID: 32216987]
    SK-MEL-28 IC50
    > 100 μM
    Compound: Bisoprolol
    Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
    Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
    		[PMID: 32216987]
    SK-MEL-5 IC50
    > 100 μM
    Compound: Bisoprolol
    Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
    Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
    		[PMID: 32216987]
    In Vitro

    Bisoprolol (2 μM, 1 h) protects myocardial cells (H9c2) from ischemia/reperfusion (I/R) injury[2].
    Bisoprolol (2 μM, 1 h) reduces the H/R-induced ROS production and apoptosis in H9c2 cells[2].
    Bisoprolol (2 μM, 1 h) increases AKT and GSK3β phosphorylation in H9c2 cells[2].
    Bisoprolol (100 μM, 24 h) reverses Epinephrine-inhibited emigration in cholesterol-loaded DCs (dendritic cell) through increasing in β-arrestin 2, CCR7 and PI3K phosphorylation[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Bisoprolol Related Antibodies

    Cell Viability Assay[2]

    Cell Line: H9c2 cells
    Concentration: 0.2, 2, 20 μM
    Incubation Time: 1 h
    Result: Elevated the survival rates of cardiomyocytes subjected to H/R (hypoxia/reoxygenation) to 73.20%, 90.38%, 81.25% respectively.

    Cell Migration Assay [3]

    Cell Line: DCs
    Concentration: 100 μM
    Incubation Time: 6, 12, 24 h
    Result: Increased the amount of migrating cells by 46.00% (6 h), 64.25% (12 h) and 55.74% (24 h).
    In Vivo

    Bisoprolol (oral administration, 5 mg/kg, for 1 week) increases left ventricular ejection fraction (LVEF) and decreases the heart rate value[2].
    Bisoprolol (oral gavage, 8 mg/kg, daily for four weeks) shows protective effects against Cadmium-induced myocardial toxicity in rats[4].
    Bisoprolol (oral gavage, 1 mg/kg, daily for 6 weeks) reverses small conductance calcium-activated potassium channel (SK) remodeling in a volume-overload rat model[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Ischemia/reperfusion (I/R) injury rats[2]
    Dosage: 0.5, 5, 10 mg/kg
    Administration: Oral administration, for 1 week, prior to 0.5 h ischemia/4 h reperfusion.
    Result: Reduced infarct size from 44% in I/R group to 31% in treated group.
    Animal Model: Cadmium-induced rats[4]
    Dosage: 2, 8 mg/kg
    Administration: Oral gavage, daily for four weeks.
    Result: Decreased mean arterial pressure (MAP) at 8 mg/kg.
    Decreased serum biomarkers (ALT, AST) and NF-kB p65 expression and TNF-α levels (cardiac tissue samples) at 8 mg/kg.
    Clinical Trial
    Molecular Weight

    325.44

    Formula

    C18H31NO4
    CAS No.
    Appearance

    Liquid (Density: 1.033±0.06 g/cm3)

    Color

    Colorless to light yellow

    SMILES

    OC(CNC(C)C)COC1=CC=C(COCCOC(C)C)C=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 350 mg/mL (1075.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0728 mL 15.3638 mL 30.7276 mL
    5 mM 0.6146 mL 3.0728 mL 6.1455 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.0728 mL 15.3638 mL 30.7276 mL 76.8191 mL
    5 mM 0.6146 mL 3.0728 mL 6.1455 mL 15.3638 mL
    10 mM 0.3073 mL 1.5364 mL 3.0728 mL 7.6819 mL
    15 mM 0.2049 mL 1.0243 mL 2.0485 mL 5.1213 mL
    20 mM 0.1536 mL 0.7682 mL 1.5364 mL 3.8410 mL
    25 mM 0.1229 mL 0.6146 mL 1.2291 mL 3.0728 mL
    30 mM 0.1024 mL 0.5121 mL 1.0243 mL 2.5606 mL
    40 mM 0.0768 mL 0.3841 mL 0.7682 mL 1.9205 mL
    50 mM 0.0615 mL 0.3073 mL 0.6146 mL 1.5364 mL
    60 mM 0.0512 mL 0.2561 mL 0.5121 mL 1.2803 mL
    80 mM 0.0384 mL 0.1920 mL 0.3841 mL 0.9602 mL
    100 mM 0.0307 mL 0.1536 mL 0.3073 mL 0.7682 mL
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    Bisoprolol Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Bisoprolol66722-44-9Adrenergic ReceptorBeta Receptorhypertensionheart failureischemiahypoxiamyocardial toxicityAMIH9c2DC cellSK channelInhibitorinhibitorinhibit

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