2. Anti-infection GPCR/G Protein
  3. Fungal Prostaglandin Receptor
  4. Coniferin

Coniferin (Laricin) is a glucoside of coniferyl alcohol. Coniferin inhibits fungal melanization. Coniferin inhibits the release of certain hormones from cells, including Prostaglandin E2 and Thromboxane B2.

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Coniferin Chemical Structure

Coniferin Chemical Structure

CAS No. : 531-29-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Coniferin:

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1 Publications Citing Use of MCE Coniferin

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  • Biological Activity

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  • References

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Description

Coniferin (Laricin) is a glucoside of coniferyl alcohol. Coniferin inhibits fungal melanization. Coniferin inhibits the release of certain hormones from cells, including Prostaglandin E2 and Thromboxane B2[1][2][3].

IC50 & Target

Fungal[1]
In Vitro

Coniferin (100 μM) inhibits melanization of Verticillium longisporum in vitro[1].
Coniferin (100 μM; 1 h) significantly reduces the release of Prostaglandin E2 (HY-101952) (IC50 value: 75.2 μM) from ionophore-stimulated mouse peritoneal macrophages[2].
Coniferin (100 μM) significantly reduces the release of Thromboxane B2 (HY-113331) (IC50 value: 619 μM) from ionophore-stimulated human platelets[2].
Coniferin (50 μM; 20 min) shows strong ATP-dependent transport activity in membrane vesicles prepared from differentiating xylem tissues of hybrid poplar, poplar, Japanese cypress and pine[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

342.34

Formula

C16H22O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(C=C(/C=C/CO)C=C1)=C1O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (292.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9211 mL 14.6054 mL 29.2107 mL
5 mM 0.5842 mL 2.9211 mL 5.8421 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.13%

Data Sheet (275 KB) SDS (393 KB)

COA (248 KB) HNMR (296 KB) RP-HPLC (219 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9211 mL 14.6054 mL 29.2107 mL 73.0268 mL
5 mM 0.5842 mL 2.9211 mL 5.8421 mL 14.6054 mL
10 mM 0.2921 mL 1.4605 mL 2.9211 mL 7.3027 mL
15 mM 0.1947 mL 0.9737 mL 1.9474 mL 4.8685 mL
20 mM 0.1461 mL 0.7303 mL 1.4605 mL 3.6513 mL
25 mM 0.1168 mL 0.5842 mL 1.1684 mL 2.9211 mL
30 mM 0.0974 mL 0.4868 mL 0.9737 mL 2.4342 mL
40 mM 0.0730 mL 0.3651 mL 0.7303 mL 1.8257 mL
50 mM 0.0584 mL 0.2921 mL 0.5842 mL 1.4605 mL
60 mM 0.0487 mL 0.2434 mL 0.4868 mL 1.2171 mL
80 mM 0.0365 mL 0.1826 mL 0.3651 mL 0.9128 mL
100 mM 0.0292 mL 0.1461 mL 0.2921 mL 0.7303 mL
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Coniferin Related Classifications

Keywords:

Coniferin531-29-3LaricinFungalProstaglandin ReceptorVerticillium longisporumplateletsmacrophagesmelanizationInhibitorinhibitorinhibit

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