Crinecerfont hydrochloride (Synonyms: SSR-125543 hydrochloride)

Name: Crinecerfont hydrochloride
Brand: MedChemExpress
SKU: HY-106203A
Rating: 4.5 (1 reviews)

Cat. No.: HY-106203A Purity: 98.06%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Crinecerfont (SSR-125543) hydrochloride is a potent, orally active, non-peptide CRF1 receptor antagonist. Crinecerfont can be used for Classic congenital adrenal hyperplasia (CAH) research. Crinecerfont (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Crinecerfont hydrochloride Chemical Structure

CAS No. : 321839-75-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Crinecerfont hydrochloride:

(R)-Crinecerfont Get quote
Crinecerfont Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Crinecerfont (SSR-125543) hydrochloride is a potent, orally active, non-peptide CRF1 receptor antagonist. Crinecerfont can be used for Classic congenital adrenal hyperplasia (CAH) research^[1]. Crinecerfont (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

IC50: CRF1 receptor

Clinical Trial

Molecular Weight

519.50

Formula

C₂₇H₂₉Cl₂FN₂OS

CAS No.

321839-75-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

C#CCN(C1=NC(C2=C(C=C(C(C)=C2)OC)Cl)=C(S1)C)[C@H](C3=CC(F)=C(C=C3)C)CC4CC4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (192.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9249 mL	9.6246 mL	19.2493 mL
5 mM	0.3850 mL	1.9249 mL	3.8499 mL
10 mM	0.1925 mL	0.9625 mL	1.9249 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.06%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (254 KB) HNMR (271 KB) RP-HPLC (268 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia (CAHtalyst).

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9249 mL	9.6246 mL	19.2493 mL	48.1232 mL
	5 mM	0.3850 mL	1.9249 mL	3.8499 mL	9.6246 mL
	10 mM	0.1925 mL	0.9625 mL	1.9249 mL	4.8123 mL
	15 mM	0.1283 mL	0.6416 mL	1.2833 mL	3.2082 mL
	20 mM	0.0962 mL	0.4812 mL	0.9625 mL	2.4062 mL
	25 mM	0.0770 mL	0.3850 mL	0.7700 mL	1.9249 mL
	30 mM	0.0642 mL	0.3208 mL	0.6416 mL	1.6041 mL
	40 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2031 mL
	50 mM	0.0385 mL	0.1925 mL	0.3850 mL	0.9625 mL
	60 mM	0.0321 mL	0.1604 mL	0.3208 mL	0.8021 mL
	80 mM	0.0241 mL	0.1203 mL	0.2406 mL	0.6015 mL
	100 mM	0.0192 mL	0.0962 mL	0.1925 mL	0.4812 mL

Crinecerfont hydrochloride Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crinecerfont321839-75-2SSR-125543SSR125543SSR 125543CFTRCystic fibrosis transmembrane conductance regulatorcongenitaladrenalhyperplasiaCAHdisorderInhibitorinhibitorinhibit

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Crinecerfont hydrochloride (Synonyms: SSR-125543 hydrochloride)

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Other Forms of Crinecerfont hydrochloride:

Crinecerfont hydrochloride Related Antibodies

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

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References

Customer Review

Molarity Calculator

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Complete Stock Solution Preparation Table

Crinecerfont hydrochloride Related Classifications

Keywords:

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