2. Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage Neuronal Signaling GPCR/G Protein Immunology/Inflammation
  3. Endogenous Metabolite Apoptosis DNA/RNA Synthesis α-synuclein Lipoxygenase Opioid Receptor Interleukin Related TNF Receptor
  4. Cuminaldehyde

Cuminaldehyde  (Synonyms: p-Isopropylbenzaldehyde)

Cat. No.: HY-Y0790 Purity: 99.03%
SDS COA Handling Instructions

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Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL), α-glucosidase (IC50=0.5 mg/mL) and lipoxygenase (IC50=1370 μM). Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases.

For research use only. We do not sell to patients.

Cuminaldehyde Chemical Structure

Cuminaldehyde Chemical Structure

CAS No. : 122-03-2

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 28 In-stock
Solution
10 mM * 1 mL in DMSO USD 28 In-stock
Liquid
1 g USD 25 In-stock
5 g USD 55 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cuminaldehyde:

Cuminaldehyde Related Antibodies

Top Publications Citing Use of Products

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL), α-glucosidase (IC50=0.5 mg/mL) and lipoxygenase (IC50=1370 μM). Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases[1][2][3][4][5][6][7].

In Vitro

Cuminaldehyde (1 mM; 24-96 h) can effectively inhibit α-synuclein (α-SN) fibrillation. The presence of α-SN fibrillation inducer Spermidine (HY-B1776) enhances the inhibitory effect, which is even stronger than the inhibitory effect of Baicalein (HY-N0196)[1].
Cuminaldehyde (0-160 μM; 12-48 h) inhibits the proliferation of human colon COLO 205 cells and induces cell apoptosis[2].
Cuminaldehyde (0.5 and 1.5 μM; 5 d) inhibits the growth of Aspergillus flavus (IC50=0.25 μL/mL) and induces necrosis of Aspergillus flavus[5].
Cuminaldehyde (0-0.8 μL/mL; 5 d) inhibits the synthesis of aflatoxin (AFB1), a secondary metabolite of Aspergillus flavus[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cuminaldehyde Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Human colon COLO 205 cells
Concentration: 0, 10, 20, 40, 80 and 160 μM
Incubation Time: 12-48 h
Result: Reduced mitochondrial membrane potential, leads to lysosomal vacuolization, upregulates acidic compartment volume and cytotoxicity.

Real Time qPCR[5]

Cell Line: Aspergillus flavus
Concentration: 0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7 and 0.8 μL/mL
Incubation Time: 5 days
Result: Reduced the expression of genes related to AFB1 synthesis.
In Vivo

Cuminaldehyde (5-20 mg/kg; intratumoral injection; once a day for 42 days) inhibits tumor growth in mice bearing human colorectal cancer COLO 205 xenografts[2].
Cuminaldehyde (50-200 mg/kg; i.g.; single dose injection 30 minutes before hot plate test) significantly reduces the latency of nociceptive response in rats in hot plate test[6].
Cuminaldehyde (12.5-50 mg/kg; i.p.; single dose injection 30 minutes before the test) significantly inhibits pain perception in mice with abdominal pain induced by Acetic acid (HY-Y0319) and formalin[6].
Cuminaldehyde (25-100 mg/kg; i.p.; once daily for 14 days) significantly alleviates allodynia and hyperalgesia in rats with chronic constriction injury (CCI) model[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human colorectal cancer COLO 205 xenograft mice[2]
Dosage: 5, 10 and 20 mg/kg
Administration: Intratumoral injection
Result: Inhibited tumor growth in mice, with tumor volumes reduced by 48.9% and 69.4% at doses of 10 and 20 mg/kg, respectively.
Animal Model: Chronic constriction injury (CCI) model rat[6]
Dosage: 25, 50 and 100 mg/kg
Administration: i.p.; 1 time per day for 14 days
Result: Reduced serum TNF-α and IL-1β levels.
Molecular Weight

148.20

Formula

C10H12O
CAS No.
Appearance

Liquid (Density: 0.977 g/cm3)

Color

Colorless to light yellow

SMILES

O=CC1=CC=C(C(C)C)C=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (674.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7476 mL 33.7382 mL 67.4764 mL
5 mM 1.3495 mL 6.7476 mL 13.4953 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.03%

SDS (393 KB)

COA (245 KB) HNMR (235 KB) RP-HPLC (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.7476 mL 33.7382 mL 67.4764 mL 168.6910 mL
5 mM 1.3495 mL 6.7476 mL 13.4953 mL 33.7382 mL
10 mM 0.6748 mL 3.3738 mL 6.7476 mL 16.8691 mL
15 mM 0.4498 mL 2.2492 mL 4.4984 mL 11.2461 mL
20 mM 0.3374 mL 1.6869 mL 3.3738 mL 8.4345 mL
25 mM 0.2699 mL 1.3495 mL 2.6991 mL 6.7476 mL
30 mM 0.2249 mL 1.1246 mL 2.2492 mL 5.6230 mL
40 mM 0.1687 mL 0.8435 mL 1.6869 mL 4.2173 mL
50 mM 0.1350 mL 0.6748 mL 1.3495 mL 3.3738 mL
60 mM 0.1125 mL 0.5623 mL 1.1246 mL 2.8115 mL
80 mM 0.0843 mL 0.4217 mL 0.8435 mL 2.1086 mL
100 mM 0.0675 mL 0.3374 mL 0.6748 mL 1.6869 mL
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Cuminaldehyde Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cuminaldehyde122-03-2p-IsopropylbenzaldehydeEndogenous MetaboliteApoptosisDNA/RNA Synthesisα-synucleinLipoxygenaseOpioid ReceptorInterleukin RelatedTNF Receptorα-SynLOXILTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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