2. Apoptosis
  3. Necroptosis Apoptosis
  4. Cyclamic acid sodium

Cyclamic acid sodium  (Synonyms: Sodium cyclamate; Cyclohexylsulfamic acid sodium)

Cat. No.: HY-W014839 Purity: ≥98.0%
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Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine.

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Cyclamic acid sodium Chemical Structure

Cyclamic acid sodium Chemical Structure

CAS No. : 139-05-9

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Cyclamic acid sodium:

Cyclamic acid sodium Related Antibodies

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Description

Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine[1][2][3][4][5].

IC50 & Target

BMP2[3]
In Vitro

Cyclamic acid sodium (12-24 mM; 89 days) can lead to progressive abnormalities and focal necrosis of urinary tract epithelium of bladder organ in rats in vitro[2].
Cyclamic acid sodium (0-0.10 μM; 24-72 h) inhibits cell proliferation, induces apoptosis, decreases cell mineralization and the expression of BMP2 in osteoblasts[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclamic acid sodium Related Antibodies

Cell Viability Assay[3]

Cell Line: Pre-osteoblasts (MC3T3E1) cells
Concentration: 0, 0.02, 0.04, 0.06, 0.08 and 0.10 μM
Incubation Time: 24, 48 and 72 h
Result: Inhibited cell proliferation in a time- and concentration-dependent manner.
In Vivo

Cyclamic acid sodium (0.7-7.0% in diet; Feed administration; 80 weeks) is 7.0% of dietary level, it has no carcinogenic effect on mice, and the concentration without adverse effect on mice is 3.5% of dietary level[4].
Cyclamic acid sodium (440 μM; Pancreatic perfusion; Single dose) has no effect on arginine-induced insulin and glucagon secretion in pancreas of perfusion rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice of the ASH-CS1 strain[4]
Dosage: Diet containing 0.7, 1.75, 3.5 and 7.0%
Administration: Feed administration; 80 weeks
Result: Slightly reduced rate of weight gain during the last 6 months of the study, but this was not thought to represent a toxic effect.
Caused mild anemia in mice at a dose of 7.0%.
Did not exert a carcinogenic effect in mice at dietary levels up to 7.0% and that the no-untoward-effect level was 3.5%.
Animal Model: Arginine treated wistar strain male rats (250-300 g)[5]
Dosage: 440 μM
Administration: Pancreatic perfusion; Single dose
Result: Did not influence arginine-induced insulin and glucagon secretion in the perfused rat pancreas.
Molecular Weight

201.22

Formula

C6H12NNaO3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(NC1CCCCC1)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (248.48 mM; Need ultrasonic)

DMSO : 20 mg/mL (99.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9697 mL 24.8484 mL 49.6968 mL
5 mM 0.9939 mL 4.9697 mL 9.9394 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2 mg/mL (9.94 mM); Clear solution

    This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2 mg/mL (9.94 mM); Clear solution

    This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (250 KB) HNMR (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.9697 mL 24.8484 mL 49.6968 mL 124.2421 mL
5 mM 0.9939 mL 4.9697 mL 9.9394 mL 24.8484 mL
10 mM 0.4970 mL 2.4848 mL 4.9697 mL 12.4242 mL
15 mM 0.3313 mL 1.6566 mL 3.3131 mL 8.2828 mL
20 mM 0.2485 mL 1.2424 mL 2.4848 mL 6.2121 mL
25 mM 0.1988 mL 0.9939 mL 1.9879 mL 4.9697 mL
30 mM 0.1657 mL 0.8283 mL 1.6566 mL 4.1414 mL
40 mM 0.1242 mL 0.6212 mL 1.2424 mL 3.1061 mL
50 mM 0.0994 mL 0.4970 mL 0.9939 mL 2.4848 mL
60 mM 0.0828 mL 0.4141 mL 0.8283 mL 2.0707 mL
80 mM 0.0621 mL 0.3106 mL 0.6212 mL 1.5530 mL
H2O 100 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2424 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclamic acid sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclamic acid139-05-9Sodium cyclamateCyclohexylsulfamic acidNecroptosisApoptosisSweetening agentOsteoblastsBladder cancerInhibitorinhibitorinhibit

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