2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. Cyclo(CKLIIF) TFA

Cyclo CKLIIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 2.6 and 2.2 μM, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclo(CKLIIF) TFA Chemical Structure

Cyclo(CKLIIF) TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 220 In-stock
10 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cyclo(CKLIIF) TFA:

Cyclo(CKLIIF) TFA Related Antibodies

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HIF-1α HIF

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Description

Cyclo CKLIIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 2.6 and 2.2 μM, respectively[1].

Molecular Weight

831.99

Formula

C38H60F3N7O8S
Appearance

Solid

Color

White to off-white

Sequence

Cyclo(Cys-Lys-Leu-Ile-Ile-Phe)
Sequence Shortening

Cyclo(CKLIIF)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (120.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2019 mL 6.0097 mL 12.0194 mL
5 mM 0.2404 mL 1.2019 mL 2.4039 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.12%

SDS (252 KB)

COA (251 KB) RP-HPLC (113 KB) MS (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2019 mL 6.0097 mL 12.0194 mL 30.0484 mL
5 mM 0.2404 mL 1.2019 mL 2.4039 mL 6.0097 mL
10 mM 0.1202 mL 0.6010 mL 1.2019 mL 3.0048 mL
15 mM 0.0801 mL 0.4006 mL 0.8013 mL 2.0032 mL
20 mM 0.0601 mL 0.3005 mL 0.6010 mL 1.5024 mL
25 mM 0.0481 mL 0.2404 mL 0.4808 mL 1.2019 mL
30 mM 0.0401 mL 0.2003 mL 0.4006 mL 1.0016 mL
40 mM 0.0300 mL 0.1502 mL 0.3005 mL 0.7512 mL
50 mM 0.0240 mL 0.1202 mL 0.2404 mL 0.6010 mL
60 mM 0.0200 mL 0.1002 mL 0.2003 mL 0.5008 mL
80 mM 0.0150 mL 0.0751 mL 0.1502 mL 0.3756 mL
100 mM 0.0120 mL 0.0601 mL 0.1202 mL 0.3005 mL
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Cyclo(CKLIIF) TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(CKLIIF)HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHT-REx-293786-OMCF-7Inhibitorinhibitorinhibit

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