1. Cell Cycle/DNA Damage Epigenetics
  2. HDAC
  3. CYD19

CYD19  (Synonyms: Snail/HDAC-IN-1)

Cat. No.: HY-144315 Purity: 95.48%
COA Handling Instructions

CYD19 is a potent Snail/HDAC dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis.

For research use only. We do not sell to patients.

CYD19 Chemical Structure

CYD19 Chemical Structure

CAS No. : 2415281-52-4

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5 mg USD 150 In-stock
10 mg USD 250 In-stock
25 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

CYD19 is a potent Snail/HDAC dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis[1].

IC50 & Target[1]

HDAC1

0.405 μM (IC50)

Snail

0.18 μM (Kd)

In Vitro

CYD19 (compound 9n) shows antiproliferative activity in HCT-116 cell lines with an IC50 of 0.0751 μM. CYD19 shows a good inhibitory effect on NCI–H522 (GI50=0.0488 μM), MDA-MB-435 (GI50=0.0361 μM), and MCF7 (GI50=0.0518 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

488.54

Formula

C24H21FN8OS

CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(NC1=CC=C(F)C=C1N)C2=CC=C(CSC(N=C3NC4=NNC(C)=C4)=NN5C3=CC=C5)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (255.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0469 mL 10.2346 mL 20.4692 mL
5 mM 0.4094 mL 2.0469 mL 4.0938 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0469 mL 10.2346 mL 20.4692 mL 51.1729 mL
5 mM 0.4094 mL 2.0469 mL 4.0938 mL 10.2346 mL
10 mM 0.2047 mL 1.0235 mL 2.0469 mL 5.1173 mL
15 mM 0.1365 mL 0.6823 mL 1.3646 mL 3.4115 mL
20 mM 0.1023 mL 0.5117 mL 1.0235 mL 2.5586 mL
25 mM 0.0819 mL 0.4094 mL 0.8188 mL 2.0469 mL
30 mM 0.0682 mL 0.3412 mL 0.6823 mL 1.7058 mL
40 mM 0.0512 mL 0.2559 mL 0.5117 mL 1.2793 mL
50 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0235 mL
60 mM 0.0341 mL 0.1706 mL 0.3412 mL 0.8529 mL
80 mM 0.0256 mL 0.1279 mL 0.2559 mL 0.6397 mL
100 mM 0.0205 mL 0.1023 mL 0.2047 mL 0.5117 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CYD19
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