1. Cell Cycle/DNA Damage Epigenetics
  2. HDAC
  3. CYD19

CYD19  (Synonyms: Snail/HDAC-IN-1)

Cat. No.: HY-144315 Purity: 95.48%
SDS COA Handling Instructions

CYD19 is a potent Snail/HDAC dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis.

For research use only. We do not sell to patients.

CYD19 Chemical Structure

CYD19 Chemical Structure

CAS No. : 2415281-52-4

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10 mg USD 250 In-stock
25 mg USD 550 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

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Description

CYD19 is a potent Snail/HDAC dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis[1].

IC50 & Target[1]

HDAC1

0.405 μM (IC50)

Snail

0.18 μM (Kd)

Cellular Effect
Cell Line Type Value Description References
786-0 GI50
0.466 μM
Compound: 9n
Antiproliferative activity against human 786-0 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human 786-0 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
A498 GI50
0.623 μM
Compound: 9n
Antiproliferative activity against human A498 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human A498 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
A549 GI50
0.886 μM
Compound: 9n
Antiproliferative activity against human A549 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human A549 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
ACHN GI50
1.24 μM
Compound: 9n
Antiproliferative activity against human ACHN cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human ACHN cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
BT-549 GI50
0.296 μM
Compound: 9n
Antiproliferative activity against human BT-549 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human BT-549 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
CCRF-CEM GI50
0.411 μM
Compound: 9n
Antiproliferative activity against human CCRF-CEM cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human CCRF-CEM cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
COLO 205 GI50
0.296 μM
Compound: 9n
Antiproliferative activity against human COLO 205 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human COLO 205 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
DU-145 GI50
0.461 μM
Compound: 9n
Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
EKVX GI50
0.919 μM
Compound: 9n
Antiproliferative activity against human EKVX cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human EKVX cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
HCC 2998 GI50
0.677 μM
Compound: 9n
Antiproliferative activity against human HCC 2998 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human HCC 2998 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
HCT-116 IC50
0.0751 μM
Compound: 9n
Antiproliferative activity against human HCT-116 cells assessed as cell viability at 1 uM incubated for 72 hrs by luminescence assay
Antiproliferative activity against human HCT-116 cells assessed as cell viability at 1 uM incubated for 72 hrs by luminescence assay
[PMID: 34995925]
HCT-116 GI50
0.494 μM
Compound: 9n
Antiproliferative activity against human HCT-116 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human HCT-116 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
HCT-15 GI50
0.424 μM
Compound: 9n
Antiproliferative activity against human HCT-15 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human HCT-15 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
HL-60 GI50
0.268 μM
Compound: 9n
Antiproliferative activity against human HL-60 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human HL-60 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
HOP-62 GI50
0.556 μM
Compound: 9n
Antiproliferative activity against human HOP-62 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human HOP-62 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
HOP-92 GI50
3.68 μM
Compound: 9n
Antiproliferative activity against human HOP-92 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human HOP-92 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
Hs-578T GI50
0.429 μM
Compound: 9n
Antiproliferative activity against human Hs-578T cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human Hs-578T cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
HT-29 GI50
0.322 μM
Compound: 9n
Antiproliferative activity against human HT-29 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human HT-29 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
IGROV-1 GI50
0.558 μM
Compound: 9n
Antiproliferative activity against human IGROV-1 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human IGROV-1 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
K562 GI50
0.0487 μM
Compound: 9n
Antiproliferative activity against human K562 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human K562 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
KM12 GI50
0.284 μM
Compound: 9n
Antiproliferative activity against human KM12 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human KM12 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
LOX IMVI GI50
0.665 μM
Compound: 9n
Antiproliferative activity against human LOX IMVI cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human LOX IMVI cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
M14 GI50
0.289 μM
Compound: 9n
Antiproliferative activity against human M14 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human M14 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
Malme-3M GI50
1.83 μM
Compound: 9n
Antiproliferative activity against human Malme-3M cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human Malme-3M cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
MCF7 GI50
0.0518 μM
Compound: 9n
Antiproliferative activity against human MCF7 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
MDA-MB-231 GI50
0.854 μM
Compound: 9n
Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
MDA-MB-435 GI50
0.0361 μM
Compound: 9n
Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
MDA-MB-468 GI50
0.432 μM
Compound: 9n
Antiproliferative activity against human MDA-MB-468 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human MDA-MB-468 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
MOLT-4 GI50
0.508 μM
Compound: 9n
Antiproliferative activity against human MOLT-4 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human MOLT-4 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
NCI/ADR-RES GI50
1.98 μM
Compound: 9n
Antiproliferative activity against human NCI/ADR-RES cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human NCI/ADR-RES cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
NCI-H226 GI50
2.7 μM
Compound: 9n
Antiproliferative activity against human NCI-H226 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human NCI-H226 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
NCI-H23 GI50
0.603 μM
Compound: 9n
Antiproliferative activity against human NCI-H23 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human NCI-H23 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
NCI-H322M GI50
1.01 μM
Compound: 9n
Antiproliferative activity against human NCI-H322M cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human NCI-H322M cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
NCI-H460 GI50
0.395 μM
Compound: 9n
Antiproliferative activity against human NCI-H460 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human NCI-H460 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
NCI-H522 GI50
0.0488 μM
Compound: 9n
Antiproliferative activity against human NCI-H522 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human NCI-H522 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
OVCAR-3 GI50
0.202 μM
Compound: 9n
Antiproliferative activity against human OVCAR-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human OVCAR-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
OVCAR-4 GI50
1.66 μM
Compound: 9n
Antiproliferative activity against human OVCAR-4 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human OVCAR-4 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
OVCAR-5 GI50
0.657 μM
Compound: 9n
Antiproliferative activity against human OVCAR-5 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human OVCAR-5 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
OVCAR-8 GI50
0.483 μM
Compound: 9n
Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
PC-3 GI50
0.355 μM
Compound: 9n
Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
RPMI-8226 GI50
0.514 μM
Compound: 9n
Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
RXF 393 GI50
0.301 μM
Compound: 9n
Antiproliferative activity against human RXF 393 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human RXF 393 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SF-268 GI50
1.12 μM
Compound: 9n
Antiproliferative activity against human SF-268 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SF-268 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SF-295 GI50
0.354 μM
Compound: 9n
Antiproliferative activity against human SF-295 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SF-295 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SF-539 GI50
0.282 μM
Compound: 9n
Antiproliferative activity against human SF-539 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SF-539 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SK-MEL-2 GI50
0.617 μM
Compound: 9n
Antiproliferative activity against human SK-MEL-2 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SK-MEL-2 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SK-MEL-28 GI50
2.83 μM
Compound: 9n
Antiproliferative activity against human SK-MEL-28 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SK-MEL-28 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SK-MEL-5 GI50
0.334 μM
Compound: 9n
Antiproliferative activity against human SK-MEL-5 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SK-MEL-5 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SK-OV-3 GI50
0.339 μM
Compound: 9n
Antiproliferative activity against human SK-OV-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SK-OV-3 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SN12C GI50
1.25 μM
Compound: 9n
Antiproliferative activity against human SN12C cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SN12C cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SNB-19 GI50
0.536 μM
Compound: 9n
Antiproliferative activity against human SNB-19 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SNB-19 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SNB-75 GI50
0.198 μM
Compound: 9n
Antiproliferative activity against human SNB-75 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SNB-75 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SR GI50
0.068 μM
Compound: 9n
Antiproliferative activity against human SR cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SR cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
SW-620 GI50
0.426 μM
Compound: 9n
Antiproliferative activity against human SW-620 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human SW-620 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
T47D GI50
1.12 μM
Compound: 9n
Antiproliferative activity against human T47D cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human T47D cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
TK-10 GI50
1.21 μM
Compound: 9n
Antiproliferative activity against human TK-10 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human TK-10 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
U-251 GI50
0.343 μM
Compound: 9n
Antiproliferative activity against human U-251 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human U-251 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
UACC-257 GI50
3.69 μM
Compound: 9n
Antiproliferative activity against human UACC-257 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human UACC-257 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
UACC-62 GI50
0.347 μM
Compound: 9n
Antiproliferative activity against human UACC-62 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human UACC-62 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
UO-31 GI50
1.33 μM
Compound: 9n
Antiproliferative activity against human UO-31 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
Antiproliferative activity against human UO-31 cells assessed as growth inhibition incubated for 72 hrs by luminescence assay
[PMID: 34995925]
In Vitro

CYD19 (compound 9n) shows antiproliferative activity in HCT-116 cell lines with an IC50 of 0.0751 μM. CYD19 shows a good inhibitory effect on NCI–H522 (GI50=0.0488 μM), MDA-MB-435 (GI50=0.0361 μM), and MCF7 (GI50=0.0518 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

488.54

Formula

C24H21FN8OS

CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(NC1=CC=C(F)C=C1N)C2=CC=C(CSC(N=C3NC4=NNC(C)=C4)=NN5C3=CC=C5)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (255.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0469 mL 10.2346 mL 20.4692 mL
5 mM 0.4094 mL 2.0469 mL 4.0938 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0469 mL 10.2346 mL 20.4692 mL 51.1729 mL
5 mM 0.4094 mL 2.0469 mL 4.0938 mL 10.2346 mL
10 mM 0.2047 mL 1.0235 mL 2.0469 mL 5.1173 mL
15 mM 0.1365 mL 0.6823 mL 1.3646 mL 3.4115 mL
20 mM 0.1023 mL 0.5117 mL 1.0235 mL 2.5586 mL
25 mM 0.0819 mL 0.4094 mL 0.8188 mL 2.0469 mL
30 mM 0.0682 mL 0.3412 mL 0.6823 mL 1.7058 mL
40 mM 0.0512 mL 0.2559 mL 0.5117 mL 1.2793 mL
50 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0235 mL
60 mM 0.0341 mL 0.1706 mL 0.3412 mL 0.8529 mL
80 mM 0.0256 mL 0.1279 mL 0.2559 mL 0.6397 mL
100 mM 0.0205 mL 0.1023 mL 0.2047 mL 0.5117 mL
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CYD19
Cat. No.:
HY-144315
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