DDMS (Synonyms: Dibromo-dodecenyl-methylsulfimide)

Cat. No.: HY-121188 Purity: 99.19%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

DDMS (Dibromo-dodecenyl-methylsulfimide) is a selective 20-HETE production inhibitor. DDMS attenuates the vasodilatory response to sodium nitroprusside (SNP).

For research use only. We do not sell to patients.

DDMS Chemical Structure

CAS No. : 206052-03-1

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

DDMS (Dibromo-dodecenyl-methylsulfimide) is a selective 20-HETE production inhibitor. DDMS attenuates the vasodilatory response to sodium nitroprusside (SNP)^[1].

IC₅₀ & Target

20-HETE^[1]

Molecular Weight

433.20

Formula

C₁₃H₂₃Br₂NO₃S

CAS No.

206052-03-1

Appearance

Solid

Color

White to off-white

SMILES

Br/C(Br)=C\CCCCCCCCCC(NS(=O)(C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (230.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3084 mL	11.5420 mL	23.0840 mL
5 mM	0.4617 mL	2.3084 mL	4.6168 mL
10 mM	0.2308 mL	1.1542 mL	2.3084 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Saline
Solubility: ≥ 2.5 mg/mL (5.77 mM); Clear solution

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 10 mg/mL (23.08 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.19%

Select Batch:

Data Sheet (266 KB) SDS (555 KB)

COA (241 KB) HNMR (227 KB) LCMS (201 KB)

Handling Instructions (2659 KB)

References

[1]. Alonso-Galicia M, et al. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. Hypertension. 1997 Jan;29(1 Pt 2):320-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3084 mL	11.5420 mL	23.0840 mL	57.7101 mL
	5 mM	0.4617 mL	2.3084 mL	4.6168 mL	11.5420 mL
	10 mM	0.2308 mL	1.1542 mL	2.3084 mL	5.7710 mL
	15 mM	0.1539 mL	0.7695 mL	1.5389 mL	3.8473 mL
	20 mM	0.1154 mL	0.5771 mL	1.1542 mL	2.8855 mL
	25 mM	0.0923 mL	0.4617 mL	0.9234 mL	2.3084 mL
	30 mM	0.0769 mL	0.3847 mL	0.7695 mL	1.9237 mL
	40 mM	0.0577 mL	0.2886 mL	0.5771 mL	1.4428 mL
	50 mM	0.0462 mL	0.2308 mL	0.4617 mL	1.1542 mL
	60 mM	0.0385 mL	0.1924 mL	0.3847 mL	0.9618 mL
	80 mM	0.0289 mL	0.1443 mL	0.2886 mL	0.7214 mL
	100 mM	0.0231 mL	0.1154 mL	0.2308 mL	0.5771 mL

DDMS Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDMS206052-03-1Dibromo-dodecenyl-methylsulfimideCytochrome P450CYPssodium nitroprussidevasodilatory response20-HETEInhibitorinhibitorinhibit

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