Delphinidin-3-sambubioside chloride (Synonyms: Dp3‐Sam chloride)

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Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L..

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Delphinidin-3-sambubioside chloride Chemical Structure

CAS No. : 53158-73-9

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Description

In Vitro

Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) inhibits LPS-induced iNOS expression in RAW264.7 cells^[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) suppresses the phosphorylation of ERK1/2 and MEK1/2 in RAW264.7 cells^[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) downregulates NF-κB signaling pathway in RAW264.7 cells^[1].
Delphinidin-3-sambubioside chloride (24 h) inhibits HL-60 cells proliferation by inducing apoptosis, with an IC₅₀ of 75 μM^[2].
Delphinidin-3-sambubioside chloride (100-200 µg/mL, 24 h) decreases intracellular TG levels and lipid accumulation in oleic acid-treated HepG2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	RAW264.7 cells
Concentration:	50, 100, 200 μM
Incubation Time:	30 min
Result:	Suppressed the degradation of IκB, and the phosphorylation of p65.

In Vivo

Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) inhibits mouse paw edema induced by LPS^[1].
Delphinidin-3-sambubioside chloride (30 mg/kg body, oral gavage, daily for eight weeks) decreases lipid accumulation in HFD rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) 抑制 LPS 诱导的小鼠爪水肿^[1]. Delphinidin-3-sambubioside chloride (30 mg/kg body，灌胃，每日一次，持续八周) 减少 HFD 大鼠的脂质积累^[3]。
Dosage:	15 μmol/kg
Administration:	Intraperitoneal injection (i.p.), for 4 days.
Result:	Reduced the LPS-induced paw thickness. Decreased the edema by 89.3%. Decreased the levels of LPS induced serum IL-6, MCP-1 and TNF-α.

Animal Model:	HFD-fed rats^[3]
Dosage:	30 mg/kg
Administration:	Oral gavage, daily for eight weeks.
Result:	Reduced the body weight gain, visceral fat, and abdominal fat and decreased hepatic lipid deposits.

Molecular Weight

632.95

Formula

C₂₆H₂₉ClO₁₆

CAS No.

53158-73-9

SMILES

O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@H]([C@@H](CO2)O)O)O)[C@H](OC3=C(C4=CC(O)=C(O)C(O)=C4)[O+]=C(C=C(O)C=C5O)C5=C3)O[C@H](CO)[C@H]1O.[Cl-]

Structure Classification

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sogo T, et al. Anti-inflammatory activity and molecular mechanism of delphinidin 3-sambubioside, a Hibiscus anthocyanin. Biofactors. 2015 Jan-Feb;41(1):58-65. [Content Brief]

[2]. Hou DX, et al. Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys. 2005 Aug 1;440(1):101-9. [Content Brief]

[3]. Long Q, et al. Delphinidin-3-sambubioside from Hibiscus sabdariffa. L attenuates hyperlipidemia in high fat diet-induced obese rats and oleic acid-induced steatosis in HepG2 cells. Bioengineered. 2021 Dec;12(1):3837-3849. https://pubmed.ncbi.nlm.nih.gov/34281481/ [Content Brief]

Delphinidin-3-sambubioside chloride Related Classifications

Metabolic Disease Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Delphinidin-3-sambubioside53158-73-9Dp3‐SamOthersAnthocyaninRAW264.7paw edemaLPSHepG2HFD ratlipid accumulationInhibitorinhibitorinhibit

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