PROTAC MLKL Degrader-1

Cat. No.: HY-156591 Purity: 99.76%: FAQs
Data Sheet SDS COA Handling Instructions

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PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC degrader of MLKL, with a D_max ＞90%. PROTAC MLKL Degrader-1 contains modified CRBN ligands, linker and Lenalidomide (HY-A0003)-linker fragments. PROTAC MLKL Degrader-1 abrogates cell death in a TSZ model of necroptosis.

For research use only. We do not sell to patients.

PROTAC MLKL Degrader-1 Chemical Structure

CAS No. : 3032600-90-8

Size	Price	Stock	Quantity
5 mg	USD 560	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 900	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1820	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2890	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4620	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
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Description	PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC degrader of MLKL, with a D_max ＞90%. PROTAC MLKL Degrader-1 contains modified CRBN ligands, linker and Lenalidomide (HY-A0003)-linker fragments. PROTAC MLKL Degrader-1 abrogates cell death in a TSZ model of necroptosis.
Molecular Weight	948.05
Formula	C₄₆H₅₅F₂N₉O₉S
CAS No.	3032600-90-8
Appearance	Solid
Color	Off-white to light yellow
SMILES	O=C(C1=C(NN=C1C2=CC=C(C=C2)NS(C(F)F)(=O)=O)NC3=CC=CC(OCCCCCCCC(N4CCC5(CCN(CC5)C(C6=CC=C(C(N7CCC(NC7=O)=O)=C6)OC)=O)CC4)=O)=C3)N
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation	Purity: 99.76% Select Batch: Data Sheet (264 KB) SDS (252 KB) COA (245 KB) HNMR (322 KB) RP-HPLC (257 KB) LCMS (138 KB) Handling Instructions (2659 KB)
References	[1]. Rathje OH, Perryman L, Payne RJ, Hamprecht DW. PROTACs Targeting MLKL Protect Cells from Necroptosis. J Med Chem. 2023 Aug 3. [Content Brief]