PROTAC MLKL Degrader-1

Cat. No.: HY-156591 Purity: 99.76%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC degrader of MLKL, with a D_max ＞90%. PROTAC MLKL Degrader-1 contains modified CRBN ligands, linker and Lenalidomide (HY-A0003)-linker fragments. PROTAC MLKL Degrader-1 abrogates cell death in a TSZ model of necroptosis.

For research use only. We do not sell to patients.

PROTAC MLKL Degrader-1 Chemical Structure

CAS No. : 3032600-90-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

948.05

Formula

C₄₆H₅₅F₂N₉O₉S

CAS No.

3032600-90-8

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=C(NN=C1C2=CC=C(C=C2)NS(C(F)F)(=O)=O)NC3=CC=CC(OCCCCCCCC(N4CCC5(CCN(CC5)C(C6=CC=C(C(N7CCC(NC7=O)=O)=C6)OC)=O)CC4)=O)=C3)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (105.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0548 mL	5.2740 mL	10.5480 mL
5 mM	0.2110 mL	1.0548 mL	2.1096 mL
10 mM	0.1055 mL	0.5274 mL	1.0548 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.76%

Select Batch:

Data Sheet (266 KB) SDS (252 KB)

COA (245 KB) HNMR (322 KB) RP-HPLC (257 KB) LCMS (138 KB)

Handling Instructions (2659 KB)

References

[1]. Rathje OH, Perryman L, Payne RJ, Hamprecht DW. PROTACs Targeting MLKL Protect Cells from Necroptosis. J Med Chem. 2023 Aug 3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0548 mL	5.2740 mL	10.5480 mL	26.3699 mL
	5 mM	0.2110 mL	1.0548 mL	2.1096 mL	5.2740 mL
	10 mM	0.1055 mL	0.5274 mL	1.0548 mL	2.6370 mL
	15 mM	0.0703 mL	0.3516 mL	0.7032 mL	1.7580 mL
	20 mM	0.0527 mL	0.2637 mL	0.5274 mL	1.3185 mL
	25 mM	0.0422 mL	0.2110 mL	0.4219 mL	1.0548 mL
	30 mM	0.0352 mL	0.1758 mL	0.3516 mL	0.8790 mL
	40 mM	0.0264 mL	0.1318 mL	0.2637 mL	0.6592 mL
	50 mM	0.0211 mL	0.1055 mL	0.2110 mL	0.5274 mL
	60 mM	0.0176 mL	0.0879 mL	0.1758 mL	0.4395 mL
	80 mM	0.0132 mL	0.0659 mL	0.1318 mL	0.3296 mL
	100 mM	0.0105 mL	0.0527 mL	0.1055 mL	0.2637 mL