Dihydro-β-erythroidine hydrobromide (Synonyms: DHβE hydrobromide)

Name: Dihydro-β-erythroidine hydrobromide
Brand: MedChemExpress
SKU: HY-107670
Rating: 4.5 (1 reviews)

Cat. No.: HY-107670 Purity: 99.84%: FAQs
Data Sheet SDS COA Handling Instructions

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Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC₅₀s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities.

For research use only. We do not sell to patients.

Dihydro-β-erythroidine hydrobromide Chemical Structure

CAS No. : 29734-68-7

Size	Price	Stock	Quantity
1 mg	USD 162	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 405	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 690	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Dihydro-β-erythroidine hydrobromide:

Dihydro-β-erythroidine Get quote

1 Publications Citing Use of MCE Dihydro-β-erythroidine hydrobromide

•Acta Pharmacol Sin. 2024 Mar 4. [Abstract]

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	624 nM Compound: DHbetaE	Antagonist activity at rat alpha4beta2 nAChR transfected in HEK293 cells after 10 mins by fluorescence assay in presence of nicotine Antagonist activity at rat alpha4beta2 nAChR transfected in HEK293 cells after 10 mins by fluorescence assay in presence of nicotine	[PMID: 24274400]

In Vivo

Dihydro-Beta-Erythroidine hydrobromide (DHβE hydrobromide; 10 nmol/0.5 μL) is infused into the respective areas prior to a systemic nicotine injection (0.2 mg/kg; SC). DHβE infused into the ventral tegmental area (VTA), nucleus accumbens (NAcc), or infralimbic (IL) cortex, but not prelimbic (PrL) cortex, attenuated nicotine-enhanced responding for a conditioned reinforcer (CRf)^[2].
The co-administration of Dihydro-Beta-Erythroidine hydrobromide (5.0 mg/kg; s.c) with nicotine (0.2 and 0.4 mg/kg; s.c.) prevents the development of conditioned taste aversions (CTAs)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male hooded Lister rats^[4]
Dosage:	0.5, 1.6 and 5.0 mg/kg
Administration:	S.c.
Result:	A complete blockade of the nicotine effect produced by the training dose of nicotine (0.2 mg/kg).

Molecular Weight

356.25

Formula

C₁₆H₂₂BrNO₃

CAS No.

29734-68-7

Appearance

Solid

Color

White to off-white

SMILES

CO[C@@H]1C[C@]23C(CC4=O)=C(CO4)CCN2CCC3=CC1.Br

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (280.70 mM)

DMSO : 8 mg/mL (22.46 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8070 mL	14.0351 mL	28.0702 mL
5 mM	0.5614 mL	2.8070 mL	5.6140 mL
10 mM	0.2807 mL	1.4035 mL	2.8070 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (280 KB) SDS (252 KB)

COA (257 KB) RP-HPLC (245 KB) MS (191 KB) Elemental Analysis Report (114 KB)

Handling Instructions (2659 KB)

References

[1]. Harvey SC, et al. Multiple determinants of dihydro-beta-erythroidine sensitivity on rat neuronal nicotinic receptor alpha subunits. J Neurochem. 1996 Nov;67(5):1953-9. [Content Brief]

[2]. Tabbara RI, et al. Nicotine enhances responding for conditioned reinforcement via α4β2 nicotinic acetylcholine receptors in the ventral tegmental area, but not the nucleus accumbens or the prefrontal cortex. Neuropharmacology. 2019 Apr;148:68-76. [Content Brief]

[3]. Clementson S, et al. Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine. J Am Chem Soc. 2019 Jun 5;141(22):8783-8786. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.8070 mL	14.0351 mL	28.0702 mL	70.1754 mL
	5 mM	0.5614 mL	2.8070 mL	5.6140 mL	14.0351 mL
	10 mM	0.2807 mL	1.4035 mL	2.8070 mL	7.0175 mL
	15 mM	0.1871 mL	0.9357 mL	1.8713 mL	4.6784 mL
	20 mM	0.1404 mL	0.7018 mL	1.4035 mL	3.5088 mL
H₂O	25 mM	0.1123 mL	0.5614 mL	1.1228 mL	2.8070 mL
	30 mM	0.0936 mL	0.4678 mL	0.9357 mL	2.3392 mL
	40 mM	0.0702 mL	0.3509 mL	0.7018 mL	1.7544 mL
	50 mM	0.0561 mL	0.2807 mL	0.5614 mL	1.4035 mL
	60 mM	0.0468 mL	0.2339 mL	0.4678 mL	1.1696 mL
	80 mM	0.0351 mL	0.1754 mL	0.3509 mL	0.8772 mL
	100 mM	0.0281 mL	0.1404 mL	0.2807 mL	0.7018 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Dihydro-β-erythroidine hydrobromide Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydro-β-erythroidine29734-68-7DHβEnAChRNicotinic acetylcholine receptorsantidepressantnicotinecompetitivebehavioralErythrinaalkaloidsoralInhibitorinhibitorinhibit

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Dihydro-β-erythroidine hydrobromide (Synonyms: DHβE hydrobromide)

Customer Review

Other Forms of Dihydro-β-erythroidine hydrobromide:

Dihydro-β-erythroidine hydrobromide Related Antibodies

1 Publications Citing Use of MCE Dihydro-β-erythroidine hydrobromide

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•Related Screening Libraries:

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Biological Activity

Purity & Documentation

References

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Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Dihydro-β-erythroidine hydrobromide Related Classifications

Keywords:

Your Recently Viewed Products:

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