2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Dihydro-β-erythroidine hydrobromide

Dihydro-β-erythroidine hydrobromide  (Synonyms: DHβE hydrobromide)

Cat. No.: HY-107670 Purity: 99.84%
COA Handling Instructions

Molarity Calculator

IC50: 0.19 μM (α4β4); 0.37 μM (α4β2); 0.41 μM (α3β2); 1.3 μM (α2β2); 2.3 μM (α2β4); 23.1 μM (α3β4)

Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities.

For research use only. We do not sell to patients.

Dihydro-β-erythroidine hydrobromide Chemical Structure

Dihydro-β-erythroidine hydrobromide Chemical Structure

CAS No. : 29734-68-7

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1 mg USD 162 In-stock
5 mg USD 405 In-stock
10 mg USD 690 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Dihydro-β-erythroidine hydrobromide:

Dihydro-β-erythroidine hydrobromide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Dihydro-β-erythroidine hydrobromide

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities[1][2][3].

In Vivo

Dihydro-Beta-Erythroidine hydrobromide (DHβE hydrobromide; 10 nmol/0.5 μL) is infused into the respective areas prior to a systemic nicotine injection (0.2 mg/kg; SC). DHβE infused into the ventral tegmental area (VTA), nucleus accumbens (NAcc), or infralimbic (IL) cortex, but not prelimbic (PrL) cortex, attenuated nicotine-enhanced responding for a conditioned reinforcer (CRf)[2].
The co-administration of Dihydro-Beta-Erythroidine hydrobromide (5.0 mg/kg; s.c) with nicotine (0.2 and 0.4 mg/kg; s.c.) prevents the development of conditioned taste aversions (CTAs)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male hooded Lister rats[4]
Dosage: 0.5, 1.6 and 5.0 mg/kg
Administration: S.c.
Result: A complete blockade of the nicotine effect produced by the training dose of nicotine (0.2 mg/kg).
Molecular Weight

356.25

Formula

C16H22BrNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CO[C@@H]1C[C@]23C(CC4=O)=C(CO4)CCN2CCC3=CC1.Br
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 35 mg/mL (98.25 mM; Need ultrasonic and warming)

DMSO : 8 mg/mL (22.46 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8070 mL 14.0351 mL 28.0702 mL
5 mM 0.5614 mL 2.8070 mL 5.6140 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.84%

COA (256 KB) RP-HPLC (245 KB) MS (191 KB) Elemental Analysis Report (114 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.8070 mL 14.0351 mL 28.0702 mL 70.1754 mL
5 mM 0.5614 mL 2.8070 mL 5.6140 mL 14.0351 mL
10 mM 0.2807 mL 1.4035 mL 2.8070 mL 7.0175 mL
15 mM 0.1871 mL 0.9357 mL 1.8713 mL 4.6784 mL
20 mM 0.1404 mL 0.7018 mL 1.4035 mL 3.5088 mL
H2O 25 mM 0.1123 mL 0.5614 mL 1.1228 mL 2.8070 mL
30 mM 0.0936 mL 0.4678 mL 0.9357 mL 2.3392 mL
40 mM 0.0702 mL 0.3509 mL 0.7018 mL 1.7544 mL
50 mM 0.0561 mL 0.2807 mL 0.5614 mL 1.4035 mL
60 mM 0.0468 mL 0.2339 mL 0.4678 mL 1.1696 mL
80 mM 0.0351 mL 0.1754 mL 0.3509 mL 0.8772 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dihydro-β-erythroidine hydrobromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydro-β-erythroidine29734-68-7DHβEnAChRNicotinic acetylcholine receptorsantidepressantnicotinecompetitivebehavioralErythrinaalkaloidsoralInhibitorinhibitorinhibit

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