2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Dimiracetam

Dimiracetam  (Synonyms: NT-11624)

Cat. No.: HY-106856 Purity: ≥98.0%
Data Sheet
SDS
COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Dimiracetam is an orally active compound, with anti-neuropathic activity. Dimiracetam inhibits hypersensitivity and neurological alterations, and inhibits Sorafenib (HY-10201)-induced neuropathy in cold stimulation rat models.

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Dimiracetam Chemical Structure

Dimiracetam Chemical Structure

CAS No. : 126100-97-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 68 In-stock
Solution
10 mM * 1 mL in DMSO USD 72 In-stock
Solid
5 mg USD 66 In-stock
10 mg USD 105 In-stock
25 mg USD 200 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Dimiracetam Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dimiracetam is an orally active compound, with anti-neuropathic activity. Dimiracetam inhibits hypersensitivity and neurological alterations, and inhibits Sorafenib (HY-10201)-induced neuropathy in cold stimulation rat models[1].

Clinical Trial
NCT NumberSponsorConditionStart DatePhase
NCT01444690Neurotune AG
Acquired Immunodeficiency Syndrome
January 2012Phase 2
NCT01135251Neurotune AG|Cross Research S.A.|Triclinium clinical trial project managment LTD
Neuropathy|AIDS
October 2009Phase 2
Molecular Weight

140.14

Formula

C6H8N2O2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1N(C(CC1)N2)CC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (891.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.1356 mL 35.6781 mL 71.3562 mL
5 mM 1.4271 mL 7.1356 mL 14.2712 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (14.84 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (14.84 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

Data Sheet (274 KB) SDS (393 KB)

COA (252 KB)HNMR (158 KB)MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.1356 mL 35.6781 mL 71.3562 mL 178.3905 mL
5 mM 1.4271 mL 7.1356 mL 14.2712 mL 35.6781 mL
10 mM 0.7136 mL 3.5678 mL 7.1356 mL 17.8390 mL
15 mM 0.4757 mL 2.3785 mL 4.7571 mL 11.8927 mL
20 mM 0.3568 mL 1.7839 mL 3.5678 mL 8.9195 mL
25 mM 0.2854 mL 1.4271 mL 2.8542 mL 7.1356 mL
30 mM 0.2379 mL 1.1893 mL 2.3785 mL 5.9463 mL
40 mM 0.1784 mL 0.8920 mL 1.7839 mL 4.4598 mL
50 mM 0.1427 mL 0.7136 mL 1.4271 mL 3.5678 mL
60 mM 0.1189 mL 0.5946 mL 1.1893 mL 2.9732 mL
80 mM 0.0892 mL 0.4460 mL 0.8920 mL 2.2299 mL
100 mM 0.0714 mL 0.3568 mL 0.7136 mL 1.7839 mL
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Dimiracetam Related Classifications

Keywords:

Dimiracetam126100-97-8NT-11624NT11624NT 11624iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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