2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Disodium succinate

Disodium succinate is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Disodium succinate is an intermediate product of the tricarboxylic acid cycle. Disodium succinate is an important platform chemical. Disodium succinate can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields.

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Disodium succinate Chemical Structure

Disodium succinate Chemical Structure

CAS No. : 150-90-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water USD 55 In-stock
Solid
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Based on 5 publication(s) in Google Scholar

Other Forms of Disodium succinate:

Disodium succinate Related Antibodies

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Description

Disodium succinate is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Disodium succinate is an intermediate product of the tricarboxylic acid cycle. Disodium succinate is an important platform chemical. Disodium succinate can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields[1][2][3][4][5].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vivo

Succinic acid (3-6 mg/kg; p.o.; Single dose) has anti-anxiety effects in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Elevated plus-maze test mice model[3]
Dosage: 3 mg/kg, 6 mg/kg
Administration: Oral gavage (p.o.); Single dose
Result: At doses of 3.0 and 6.0 mg/kg significantly increased the percentage of mice that entered the open arm and the percentage of time that the open arm stayed.
Animal Model: Food intake mice model [3]
Dosage: 3 mg/kg, 6 mg/kg, 12 mg/kg
Administration: Intraperitoneal injection (i.p.); Single dose
Result: Significantly increased the mice's food intake within 5 minutes after administration.
Animal Model: Stress-induced hyperthermia test mice model[3]
Dosage: 1.5 mg/kg, 3 mg/kg, 6 mg/kg
Administration: Oral gavage (p.o.); Single dose
Result: Inhibited stress-induced hyperthermia at a dose of 1.5 mg/kg.
Molecular Weight

162.05

Formula

C4H4Na2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CCC(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (154.27 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.1709 mL 30.8547 mL 61.7093 mL
5 mM 1.2342 mL 6.1709 mL 12.3419 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (617.09 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (245 KB) HNMR (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.1709 mL 30.8547 mL 61.7093 mL 154.2734 mL
5 mM 1.2342 mL 6.1709 mL 12.3419 mL 30.8547 mL
10 mM 0.6171 mL 3.0855 mL 6.1709 mL 15.4273 mL
15 mM 0.4114 mL 2.0570 mL 4.1140 mL 10.2849 mL
20 mM 0.3085 mL 1.5427 mL 3.0855 mL 7.7137 mL
25 mM 0.2468 mL 1.2342 mL 2.4684 mL 6.1709 mL
30 mM 0.2057 mL 1.0285 mL 2.0570 mL 5.1424 mL
40 mM 0.1543 mL 0.7714 mL 1.5427 mL 3.8568 mL
50 mM 0.1234 mL 0.6171 mL 1.2342 mL 3.0855 mL
60 mM 0.1028 mL 0.5142 mL 1.0285 mL 2.5712 mL
80 mM 0.0771 mL 0.3857 mL 0.7714 mL 1.9284 mL
100 mM 0.0617 mL 0.3085 mL 0.6171 mL 1.5427 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Disodium succinate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Disodium150-90-3Endogenous MetaboliteChelating agentSurfactantPlatform chemicalFlavoring agentAdditiveAnaerobicFermentationPrecursorAnxiolyticOrally activeInhibitorinhibitorinhibit

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