2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. (E,E)-Bisdemethoxycurcumin

(E,E)-Bisdemethoxycurcumin  (Synonyms: (E,E)-Curcumin III; (E,E)-Didemethoxycurcumin)

Cat. No.: HY-N0007 Purity: ≥98.0%
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(E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities.

For research use only. We do not sell to patients.

(E,E)-Bisdemethoxycurcumin Chemical Structure

(E,E)-Bisdemethoxycurcumin Chemical Structure

CAS No. : 33171-05-0

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10 mM * 1 mL in DMSO
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of (E,E)-Bisdemethoxycurcumin:

(E,E)-Bisdemethoxycurcumin Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities[1][2][3][4][5][6].

In Vitro

Bisdemethoxycurcumin (1-10 μM; 5 h) significantly inhibits HT1080 cancer cell invasion, but does not affect cell migration[5].
Bisdemethoxycurcumin (1-10 μM; 24 h) inhibits the secret of MMP-9 in HT1080 cells, and affects cancer cell invasion and metastasis[5].
Bisdemethoxycurcumin (5-50 μM; 24 h) Bisdemethoxycurcumin (5-50 μM; 24 h) significantly inhibits collagenase, MMP-2 and MMP-9 activities in HT1080, but does not inhibit uPA activity[5].
Bisdemethoxycurcumin (25 μM; 18 h, 24 h) arrests cell cycle at G1 phase, and (5-25 μM) inhibits the expression of C/EBPα and PPARγ in 3T3-L1 adipocyte 270 differentiation[6].
Bisdemethoxycurcumin inhibits lipid accumulation in adipocytes, primarily by attenuating mitotic clonal expansion (MCE) to inhibit early lipogenesis[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E,E)-Bisdemethoxycurcumin Related Antibodies
In Vivo

Bisdemethoxycurcumin (0.5% in diet; 15 weeks) significantly reduces both final body weight and body weight gain in HFD-induced obese mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

308.33

Formula

C19H16O4
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(CC(/C=C/C1=CC=C(O)C=C1)=O)/C=C/C2=CC=C(O)C=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (324.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2433 mL 16.2164 mL 32.4328 mL
5 mM 0.6487 mL 3.2433 mL 6.4866 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.11 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥98.0%

COA (243 KB) HNMR (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2433 mL 16.2164 mL 32.4328 mL 81.0820 mL
5 mM 0.6487 mL 3.2433 mL 6.4866 mL 16.2164 mL
10 mM 0.3243 mL 1.6216 mL 3.2433 mL 8.1082 mL
15 mM 0.2162 mL 1.0811 mL 2.1622 mL 5.4055 mL
20 mM 0.1622 mL 0.8108 mL 1.6216 mL 4.0541 mL
25 mM 0.1297 mL 0.6487 mL 1.2973 mL 3.2433 mL
30 mM 0.1081 mL 0.5405 mL 1.0811 mL 2.7027 mL
40 mM 0.0811 mL 0.4054 mL 0.8108 mL 2.0270 mL
50 mM 0.0649 mL 0.3243 mL 0.6487 mL 1.6216 mL
60 mM 0.0541 mL 0.2703 mL 0.5405 mL 1.3514 mL
80 mM 0.0405 mL 0.2027 mL 0.4054 mL 1.0135 mL
100 mM 0.0324 mL 0.1622 mL 0.3243 mL 0.8108 mL
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(E,E)-Bisdemethoxycurcumin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E,E)-Bisdemethoxycurcumin33171-05-0(E,E)-Curcumin III (E,E)-DidemethoxycurcuminApoptosisAutophagyadipogenesisbisdemethoxycurcumin (BDMC)high-fat dietmitotic clonal expansion (MCE)obesityInhibitorinhibitorinhibit

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