2. Anti-infection Protein Tyrosine Kinase/RTK Apoptosis
  3. Parasite VEGFR Apoptosis
  4. Ethyl cinnamate

Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC50 values of 0.30 mM and 0.38 mM in rat aorta.

For research use only. We do not sell to patients.

Ethyl cinnamate Chemical Structure

Ethyl cinnamate Chemical Structure

CAS No. : 103-36-6

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
100 g USD 30 In-stock
> 100 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ethyl cinnamate:

Ethyl cinnamate Related Antibodies

Top Publications Citing Use of Products

View All Parasite Isoform Specific Products:

View All Isoforms
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

View All VEGFR Isoform Specific Products:

View All Isoforms
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC50 values of 0.30 mM and 0.38 mM in rat aorta[1][2][3][4].

In Vitro

Ethyl cinnamate (0-80 μM, 24 h and 48 h) inhibits VEGF-induced viability, motility, tube formation of Human umbilical vein endothelial cells (HUVECs) in a VEGFR2-dependent manner and induces HUVECs apoptosis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethyl cinnamate Related Antibodies

Cell Proliferation Assay[3]

Cell Line: HUVECs
Concentration: 0-80 μM
Incubation Time: 24 h
Result: Significantly inhibited HUVECs proliferation enhanced by vascular endothelial growth factor (VEGF).

Apoptosis Analysis[3]

Cell Line: HUVECs
Concentration: 0-80 μM
Incubation Time: 48 h
Result: Increased apoptosis rate of cells and decreased the expression levels of Bcl-2/Bax with an IC50 value of 31.79 μM in HUVECs.
In Vivo

Ethyl cinnamate (1-4 μM, incubation, a single dose) inhibits blood vessel formation in zebrafish embryos[3].
Ethyl cinnamate (15, 30, 60 mg/kg, p.o., daily for 21 days) suppresses tumor growth and angiogenesis of HT29 nude mouse colon cancer xenograft model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish embryos[3]
Dosage: 1-4 μM
Administration: incubation, a single dose for 24 h and 48 h
Result: Significantly decreased the number of intact intersegmental vessels (ISVs) and inhibited the growth of SIVs in Zebrafish embryos.
Animal Model: HT29 nude mouse colon cancer xenograft model[3]
Dosage: 15, 30, 60 mg/kg
Administration: p.o., daily for 21 days
Result: Significantly inhibited the tumor growth and inhibited the expression levels of p-VEGFR2, p-Akt, p-ERK1/2, CD34, VEGF and Bcl-2/Bax in a dose-dependent manner in HT29 nude mouse colon cancer xenograft model.
Molecular Weight

176.21

Formula

C11H12O2
CAS No.
Appearance

<6°C Solid,>8°C Liquid

Color

Colorless to off-white

SMILES

O=C(OCC)/C=C/C1=CC=CC=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (567.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (567.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6750 mL 28.3752 mL 56.7505 mL
5 mM 1.1350 mL 5.6750 mL 11.3501 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (14.19 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (14.19 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.80%

COA (244 KB) HNMR (130 KB) RP-HPLC (233 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.6750 mL 28.3752 mL 56.7505 mL 141.8762 mL
5 mM 1.1350 mL 5.6750 mL 11.3501 mL 28.3752 mL
10 mM 0.5675 mL 2.8375 mL 5.6750 mL 14.1876 mL
15 mM 0.3783 mL 1.8917 mL 3.7834 mL 9.4584 mL
20 mM 0.2838 mL 1.4188 mL 2.8375 mL 7.0938 mL
25 mM 0.2270 mL 1.1350 mL 2.2700 mL 5.6750 mL
30 mM 0.1892 mL 0.9458 mL 1.8917 mL 4.7292 mL
40 mM 0.1419 mL 0.7094 mL 1.4188 mL 3.5469 mL
50 mM 0.1135 mL 0.5675 mL 1.1350 mL 2.8375 mL
60 mM 0.0946 mL 0.4729 mL 0.9458 mL 2.3646 mL
80 mM 0.0709 mL 0.3547 mL 0.7094 mL 1.7735 mL
100 mM 0.0568 mL 0.2838 mL 0.5675 mL 1.4188 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Ethyl cinnamate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethyl cinnamate103-36-6ParasiteVEGFRApoptosisVascular endothelial growth factor receptororally activenematocidalsedativevasorelaxantfragrance ingredientclearing reagentVEGFR2 signal pathwaycolorectal cancertonic contractionsrat aortaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Ethyl cinnamate
Cat. No.:
HY-Y0121
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.