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  4. Fentonium bromide

Fentonium bromide is an anti-ulcerogenic, anticholinergic and antispasmodic agent. Fentonium bromide can be used in the research of neurological conditions.

For research use only. We do not sell to patients.

Fentonium bromide Chemical Structure

Fentonium bromide Chemical Structure

CAS No. : 5868-06-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

Fentonium bromide Related Antibodies

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Description

Fentonium bromide is an anti-ulcerogenic, anticholinergic and antispasmodic agent. Fentonium bromide can be used in the research of neurological conditions[1][2][3].

In Vivo

Fentonium bromide (1 mg/kg, i.v.) is an effective antagonist of gastric secretion in rats[1].
Fentonium bromide (phentonium, 1 mg/kg, i.p.) prevents stress ulcers in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bethanechol-, pentagastrin-, and caerulein-induced gastric secretion in rats[1]
Dosage: 1 mg/kg
Administration: Intravenous injection (i.v.)
Result: Inhibited gastric acid secretion.
Animal Model: Rats[2]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Decreased both the number of pre-ulceral lesions and the number of gastroduodenal ulcers in comparison with untreated controls.
Molecular Weight

564.51

Formula

C31H34BrNO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C2=CC=CC=C2)C=C1)C[N+](C(CC3)CC4OC(C(C5=CC=CC=C5)CO)=O)(C3C4)C.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 130 mg/mL (230.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7714 mL 8.8572 mL 17.7145 mL
5 mM 0.3543 mL 1.7714 mL 3.5429 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 3.25 mg/mL (5.76 mM); Clear solution

    This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7714 mL 8.8572 mL 17.7145 mL 44.2862 mL
5 mM 0.3543 mL 1.7714 mL 3.5429 mL 8.8572 mL
10 mM 0.1771 mL 0.8857 mL 1.7714 mL 4.4286 mL
15 mM 0.1181 mL 0.5905 mL 1.1810 mL 2.9524 mL
20 mM 0.0886 mL 0.4429 mL 0.8857 mL 2.2143 mL
25 mM 0.0709 mL 0.3543 mL 0.7086 mL 1.7714 mL
30 mM 0.0590 mL 0.2952 mL 0.5905 mL 1.4762 mL
40 mM 0.0443 mL 0.2214 mL 0.4429 mL 1.1072 mL
50 mM 0.0354 mL 0.1771 mL 0.3543 mL 0.8857 mL
60 mM 0.0295 mL 0.1476 mL 0.2952 mL 0.7381 mL
80 mM 0.0221 mL 0.1107 mL 0.2214 mL 0.5536 mL
100 mM 0.0177 mL 0.0886 mL 0.1771 mL 0.4429 mL
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Fentonium bromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fentonium5868-06-4OthersOxypertineneuroprotectiveanxietyschizophreniadopamine5-HTInhibitorinhibitorinhibit

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