Feruloylputrescine

Name: Feruloylputrescine
Brand: MedChemExpress
SKU: HY-W327449
Rating: 4.5 (1 reviews)

Cat. No.: HY-W327449 Purity: 99.34%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Feruloylputrescine is an oral active phenolamide found in citrus plants and formed through the decarboxylation of L-Arginine. Feruloylputrescine inhibits monooxygenase (cntA) and reductase (cntB) and trimethylamine production. Feruloylputrescine can be used for cardiovascular diseases research.

For research use only. We do not sell to patients.

Feruloylputrescine Chemical Structure

CAS No. : 501-13-3

Size	Price	Stock	Quantity
5 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 44	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Feruloylputrescine (10 µg/mL, 24 hours) can reduce FMO3 protein expression, inhibit FMO3 mRNA expression, and decrease TMA production in hepatocellular carcinoma cell lines^[1].
Feruloylputrescine (378 µM, continuously administered until muscle strip contraction stabilized) can inhibit Noradrenaline-induced urethral smooth muscle contraction^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:	HepG2 cell line (hepatocellular carcinoma)
Concentration:	10 µg/mL
Incubation Time:	24 h
Result:	Suppressed FMO3 mRNA expression and reduced TMA levels.

Western Blot Analysis^[1]

Cell Line:	HepG2 cell line (hepatocellular carcinoma)
Concentration:	10 µg/mL
Incubation Time:	24 h
Result:	Reduced FMO3 protein expression.

In Vivo

Feruloylputrescine (administered via diet, 10 mg per g of diet daily for 6 weeks) significantly reduces TMA and TMAO levels in high-fat diet-induced mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High-fat diet-induced C57BL/6 mouse model^[1]
Dosage:	10 mg/g diet
Administration:	Administered via diet, 10 mg/g diet daily for 6 weeks
Result:	Significantly reduced TMA and TMAO levels.

Molecular Weight

264.32

Formula

C₁₄H₂₀N₂O₃

CAS No.

501-13-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=C(O)C=CC(C=CC(NCCCCN)=O)=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (18.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7833 mL	18.9165 mL	37.8329 mL
5 mM	0.7567 mL	3.7833 mL	7.5666 mL
10 mM	0.3783 mL	1.8916 mL	3.7833 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.34%

Select Batch:

Data Sheet (270 KB) SDS (644 KB)

COA (242 KB) HNMR (270 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Hana Lee, et al. Discovery of a Novel Bioactive Compound in Orange Peel Polar Fraction on the Inhibition of Trimethylamine and Trimethylamine N-Oxide through Metabolomics Approaches and In Vitro and In Vivo Assays: Feruloylputrescine Inhibits Trimethylamine via Suppressing cntA/B Enzyme. J Agric Food Chem. 2024 Apr 10;72(14):7870-7881. [Content Brief]

[2]. Nakase K, et al. Effects of pollen-extract components, diamines and derivatives of feruloylputrescine on isolated bladder and urethral smooth muscles of mice. Jpn J Pharmacol. 1990 Jun;53(2):157-64. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7833 mL	18.9165 mL	37.8329 mL	94.5823 mL
	5 mM	0.7567 mL	3.7833 mL	7.5666 mL	18.9165 mL
	10 mM	0.3783 mL	1.8916 mL	3.7833 mL	9.4582 mL
	15 mM	0.2522 mL	1.2611 mL	2.5222 mL	6.3055 mL