Fexofenadine (Synonyms: MDL-16455; Terfenadine carboxylate)

Name: Fexofenadine
Brand: MedChemExpress
SKU: HY-B0801
Rating: 5.0 (4 reviews)

Cat. No.: HY-B0801 Purity: 99.84%: FAQs
Data Sheet SDS COA Handling Instructions

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Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research.

For research use only. We do not sell to patients.

Fexofenadine Chemical Structure

CAS No. : 83799-24-0

Size	Price	Stock	Quantity
5 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 132	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
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Based on 4 publication(s) in Google Scholar

Other Forms of Fexofenadine:

4 Publications Citing Use of MCE Fexofenadine

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research^[1]^[2]^[3].

IC₅₀ & Target^[1]

H₁ Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	78 nM Compound: Fexofenadine	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting	[PMID: 21470866]
CHO-K1	IC₅₀	78 nM Compound: 37	Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting	10.1016/j.bmcl.2009.03.124
HEK293	IC₅₀	23 μM Compound: figure 2, R2C2	Inhibition of human Erg expressed in HEK293 cells assessed as rubidium efflux after 4 hrs by atomic absorbance spectrometric analysis Inhibition of human Erg expressed in HEK293 cells assessed as rubidium efflux after 4 hrs by atomic absorbance spectrometric analysis	[PMID: 22542010]
HEK293	IC₅₀	23 μM Compound: 42, Fexofenadine	Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay	[PMID: 16931010]
HEK293	IC₅₀	65 μM Compound: Fexofenadine	Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp method Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp method	[PMID: 19260734]
L929	IC₅₀	> 100 nM Compound: rac-2	Inhibition of human ERG in L929 cells by whole cell patch-clamp assay Inhibition of human ERG in L929 cells by whole cell patch-clamp assay	[PMID: 19660947]
L929	IC₅₀	> 100 μM Compound: rac-2	Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assay Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assay	[PMID: 19660947]

In Vitro

Fexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner^[2].
Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	Nasal fibroblasts
Concentration:	100 μM
Incubation Time:	1 hour
Result:	Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway.

In Vivo

Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice infected with Trichinella spiralis^[1]
Dosage:	5, 10 and 20 mg/kg
Administration:	Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks
Result:	Inhibited eosinophilia in a dose-dependent manner. Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.

Clinical Trial

Molecular Weight

501.66

Formula

C₃₂H₃₉NO₄

CAS No.

83799-24-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCN(CCCC(C4=CC=C(C(C(O)=O)(C)C)C=C4)O)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.84%

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Data Sheet (274 KB) SDS (252 KB)

COA (250 KB) HNMR (214 KB) LCMS (84 KB)

Handling Instructions (2659 KB)

References

[1]. Watanabe N, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004 Mar;4(3):367-75. [Content Brief]

[2]. Park IH, et al. Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-κB Pathways in Nasal Fibroblasts. Allergy Asthma Immunol Res. 2014 Nov;6(6):567-72. [Content Brief]

[3]. Ming X, et al. Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters. Mol Pharm. 2011 Oct 3;8(5):1677-86. [Content Brief]

Fexofenadine Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fexofenadine83799-24-0MDL-16455 Terfenadine carboxylateMDL16455MDL 16455Histamine Receptorallergic rhinitischronic idiopathic urticarialnasal fibroblastsInhibitorinhibitorinhibit

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Fexofenadine (Synonyms: MDL-16455; Terfenadine carboxylate)

Customer Review

Other Forms of Fexofenadine:

Fexofenadine Related Antibodies

4 Publications Citing Use of MCE Fexofenadine

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Histamine Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Fexofenadine Related Antibodies

Fexofenadine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

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