2. Neuronal Signaling Epigenetics Apoptosis Metabolic Enzyme/Protease
  3. Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite
  4. Garcinol

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 µM and 7.39 µM, respectively. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity.

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Garcinol Chemical Structure

Garcinol Chemical Structure

CAS No. : 78824-30-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 332 In-stock
Solution
10 mM * 1 mL in DMSO USD 332 In-stock
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1 mg USD 80 In-stock
5 mg USD 200 In-stock
10 mg USD 305 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Garcinol Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Garcinol

View All Cholinesterase (ChE) Isoform Specific Products:

View All Isoforms
AChE BChE

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View All Isoforms
CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 µM and 7.39 µM, respectively[1]. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity[2].

IC50 & Target

AChE

 

BChE

 

GCN5/PCAF

 

Human Endogenous Metabolite

 

In Vitro

Garcinol (10-50 μM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner[3].
? Garcinol (10-50 μM; 24-72 hours) induces apoptosis in HNSCC cells[3].
? Garcinol (50 μM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Garcinol Related Antibodies

Cell Proliferation Assay[3]

Cell Line: CAL27 and UMSCC1 cells
Concentration: 10, 25, 50 µM
Incubation Time: 24, 48, and 72 hours
Result: Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner.

Apoptosis Analysis[3]

Cell Line: CAL27 and UMSCC1 cells
Concentration: 10, 25, 50 µM
Incubation Time: 24, 48, and 72 hours
Result: Induced apoptosis in HNSCC cells.

Western Blot Analysis[3]

Cell Line: CAL27 cells
Concentration: 50 µM
Incubation Time: 1, 2, 4, 6 hours
Result: Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.
In Vivo

Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors[3]
Dosage: 1 and 2 mg/kg
Administration: I.p.; five times/week for 4 consecutive weeks
Result: Induced significant inhibition of tumor growth.
Molecular Weight

602.80

Formula

C38H50O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C/C(C)=C\C[C@@H](C[C@]12C([C@](C(C)([C@@H](C2)C/C=C(C)\C)C)(C/C=C(C)\C)C(C(C(C3=CC(O)=C(C=C3)O)=O)=C1O)=O)=O)C(C)=C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (82.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 20 mg/mL (33.18 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6589 mL 8.2946 mL 16.5893 mL
5 mM 0.3318 mL 1.6589 mL 3.3179 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (4.15 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥99.0%

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 1.6589 mL 8.2946 mL 16.5893 mL 41.4731 mL
5 mM 0.3318 mL 1.6589 mL 3.3179 mL 8.2946 mL
10 mM 0.1659 mL 0.8295 mL 1.6589 mL 4.1473 mL
15 mM 0.1106 mL 0.5530 mL 1.1060 mL 2.7649 mL
20 mM 0.0829 mL 0.4147 mL 0.8295 mL 2.0737 mL
25 mM 0.0664 mL 0.3318 mL 0.6636 mL 1.6589 mL
30 mM 0.0553 mL 0.2765 mL 0.5530 mL 1.3824 mL
DMSO 40 mM 0.0415 mL 0.2074 mL 0.4147 mL 1.0368 mL
50 mM 0.0332 mL 0.1659 mL 0.3318 mL 0.8295 mL
60 mM 0.0276 mL 0.1382 mL 0.2765 mL 0.6912 mL
80 mM 0.0207 mL 0.1037 mL 0.2074 mL 0.5184 mL
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Garcinol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Garcinol78824-30-3Cholinesterase (ChE)Histone AcetyltransferaseApoptosisEndogenous MetaboliteHATsHATGarciniaindicaanti-cholinesteraseBChEPCAFanti-inflammatoryanti-cancerInhibitorinhibitorinhibit

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