CTDSP2 - CTD small phosphatase 2 Gene

Homo sapiens

Also known as OS4; PSR2; SCP2

Gene ID: 10106 | Gene type: protein coding

About CTDSP2

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:57,819,927-57,846,729 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 5 paralogues. Ubiquitous expression in lung (RPKM 63.4), ovary (RPKM 53.0) and 25 other tissues.

Summary

Enables RNA polymerase II CTD heptapeptide repeat Phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CTDSP2 Products(1)

mRNA	Protein	Name
NM_005730.4	NP_005721.3	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IDA IDA: Inferred from direct assay	12721286	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16724108	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	12721286	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTDSP2 Protein Structure

NIF

0
100
200
271 a.a.

Protein Preferred Names

Protein Names

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2

CTDSP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CTDSP2	O14595	LCN2	Homo sapiens	P80188	Validated Y2H	32296183
Intra	CTDSP2	O14595	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	CTDSP2	O14595	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	CTDSP2	O14595	N4BP3	Homo sapiens	O15049	Y2H Array	32296183
Intra	CTDSP2	O14595	N4BP3	Homo sapiens	O15049	Validated Y2H	32296183
Intra	CTDSP2	O14595	N4BP3	Homo sapiens	O15049	Y2H Prey Pooling	32296183
Intra	CTDSP2	O14595	AR	Homo sapiens	P10275	Pull Down	16724108
Intra	CTDSP2	O14595	AR	Homo sapiens	P10275	Y2H	16724108
Intra	CTDSP2	O14595	AR	Homo sapiens	P10275	Anti Tag CoIP	16724108
Intra	CTDSP2	O14595	CDCA3	Homo sapiens	Q99618	Anti Tag CoIP	28514442
Intra	CTDSP2	O14595	CDCA3	Homo sapiens	Q99618	Anti Tag CoIP	27880917
Intra	CTDSP2	O14595	CDCA3	Homo sapiens	Q99618	Y2H Prey Pooling	25416956
Intra	CTDSP2	O14595	CDCA3	Homo sapiens	Q99618	Anti Tag CoIP	33961781
Intra	CTDSP2	O14595	CDCA3	Homo sapiens	Q99618	Validated Y2H	32296183
Intra	CTDSP2	O14595	CDCA3	Homo sapiens	Q99618	Y2H Array	25416956
Cross	CTDSP2	O14595	tax	Human T-cell leukemia virus 1	P14079	MAPPIT	22458338
Cross	CTDSP2	O14595	tax	Human T-cell leukemia virus 1	P14079	Y2H Pooling	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myringitis Bullosa Hemorrhagica

Bullous Myringitis

Myasthenic Syndrome, Congenital, 16

Congenital Myasthenic Syndrome 16	CMS16
Myasthenic Syndrome, Congenital, Acetazolamide-Responsive	Congenital Myasthenic Syndrome Acetazolamide-Responsive
Congenital Myasthenic Syndrome Due To Mutation In Scn4a	Congenital Myasthenic Syndrome Scn4a-Related

Acute Tympanitis

Acute Myringitis

Obsessive-Compulsive Personality Disorder

Anankastic Personality Disorder	Obsessive-Compulsive Personality
Compulsive Personality Disorder	Ocpd
Obsessional Personality Disorder

Dermatosis Papulosa Nigra

Otosclerosis

Otospongiosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03292	CTDSP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CTDSP2	VGNC	VGNC:71427
Canis familiaris	CTDSP2	VGNC	VGNC:39694
Bos taurus	CTDSP2	VGNC	VGNC:27791
Rattus norvegicus	CTDSP2	RGD	RGD:2319209
Mus musculus	CTDSP2	MGD	MGI:1098748
Felis catus	CTDSP2	VGNC	VGNC:61248

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