ZNF263 - zinc finger protein 263 Gene

Homo sapiens

Also known as FPM315; ZSCAN44; ZKSCAN12

Gene ID: 10127 | Gene type: protein coding

About ZNF263

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,283,491-3,301,401 (from NCBI)

This gene has 7 transcripts (splice variants), 137 orthologues and 31 paralogues. Ubiquitous expression in ovary (RPKM 7.9), testis (RPKM 7.1) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF263 Products(2)

mRNA	Protein	Name
NM_001411015.1	NP_001397944.1	zinc finger protein 263 isoform 2
NM_005741.5	NP_005732.2	zinc finger protein 263 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19887448	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	32051553	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19887448	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	32277030	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26089202	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	32051553	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF263 Protein Structure

SCAN

KRAB

zf-C2H2

zf-H2C2_2

0
200
400
600
683 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 263

zinc finger protein FPM315

ZNF263 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF263	O14978	ZSCAN22	Homo sapiens	P10073	Validated Y2H	32296183
Intra	ZNF263	O14978	GPATCH2L	Homo sapiens	Q9NWQ4-1	Validated Y2H	32296183
Intra	ZNF263	O14978	PPL	Homo sapiens	O60437	Validated Y2H	32296183
Intra	ZNF263	O14978	TRIM41	Homo sapiens	Q8WV44	Anti Tag CoIP	33961781
Intra	ZNF263	O14978	TRIM41	Homo sapiens	Q8WV44	Anti Tag CoIP	28514442
Intra	ZNF263	O14978	TRIM41	Homo sapiens	Q8WV44	Y2H Pooling	16189514
Intra	ZNF263	O14978	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	32296183
Intra	ZNF263	O14978	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	ZNF263	O14978	ZNF165	Homo sapiens	P49910	Validated Y2H	32296183
Intra	ZNF263	O14978	CLK3	Homo sapiens	P49761	Y2H Prey Pooling	25416956
Intra	ZNF263	O14978	CLK3	Homo sapiens	P49761	Y2H Array	25416956
Intra	ZNF263	O14978	SCAND1	Homo sapiens	P57086	Validated Y2H	32296183
Intra	ZNF263	O14978	SCAND1	Homo sapiens	P57086	Y2H Pooling	16189514
Intra	ZNF263	O14978	SCAND1	Homo sapiens	P57086	Anti Tag CoIP	33961781
Intra	ZNF263	O14978	SCAND1	Homo sapiens	P57086	Anti Tag CoIP	28514442
Intra	ZNF263	O14978	CLK2	Homo sapiens	P49760	Y2H Array	25416956
Intra	ZNF263	O14978	CLK2	Homo sapiens	P49760	Validated Y2H	25416956
Intra	ZNF263	O14978	TCAF1	Homo sapiens	Q9Y4C2	Y2H Prey Pooling	25416956
Intra	ZNF263	O14978	TCAF1	Homo sapiens	Q9Y4C2	Validated Y2H	25416956
Intra	ZNF263	O14978	JAKMIP2	Homo sapiens	Q96AA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 12

Combined Immunodeficiency Due To Malt1 Deficiency	IMD12
Immunodeficiency, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16115	ZNF263 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZNF263	VGNC	VGNC:37234
Macaca mulatta	ZNF263	VGNC	VGNC:78888
Mus musculus	ZNF263	MGD	MGI:1921370
Felis catus	ZNF263	VGNC	VGNC:80706
Canis familiaris	ZNF263	VGNC	VGNC:48683
Rattus norvegicus	ZNF263	RGD	RGD:1307301

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