JAKMIP2 - janus kinase and microtubule interacting protein 2 Gene

Homo sapiens

Also known as NECC1; JAMIP2

Gene ID: 9832 | Gene type: protein coding

About JAKMIP2

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:147,585,438-147,782,728 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 2 paralogues. Biased expression in brain (RPKM 6.2), adrenal (RPKM 0.9) and 5 other tissues.

Summary

The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

JAKMIP2 Products(4)

mRNA	Protein	Name
NM_001270934.2	NP_001257863.1	janus kinase and microtubule-interacting protein 2 isoform 2
NM_001270941.2	NP_001257870.1	janus kinase and microtubule-interacting protein 2 isoform 1
NM_001282282.2	NP_001269211.1	janus kinase and microtubule-interacting protein 2 isoform 4
NM_014790.5	NP_055605.2	janus kinase and microtubule-interacting protein 2 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

janus kinase and microtubule-interacting protein 2

CTCL tumor antigen HD-CL-04

JAKMIP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	JAKMIP2	Q96AA8	a8k932_human	Homo sapiens	A8K932	Validated Y2H	25416956
Intra	JAKMIP2	Q96AA8	a8k932_human	Homo sapiens	A8K932	Y2H Array	25416956
Intra	JAKMIP2	Q96AA8	a8k932_human	Homo sapiens	A8K932	Y2H Prey Pooling	25416956
Intra	JAKMIP2	Q96AA8	CLASP1	Homo sapiens	Q7Z460-4	Validated Y2H	25416956
Intra	JAKMIP2	Q96AA8	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	25416956
Intra	JAKMIP2	Q96AA8	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	25416956
Intra	JAKMIP2	Q96AA8	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	JAKMIP2	Q96AA8	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	JAKMIP2	Q96AA8	CCDC88B	Homo sapiens	A6NC98	Y2H Prey Pooling	32296183
Intra	JAKMIP2	Q96AA8	CCDC88B	Homo sapiens	A6NC98	Y2H Array	32296183
Intra	JAKMIP2	Q96AA8	SMARCE1	Homo sapiens	Q969G3	Y2H Prey Pooling	25416956
Intra	JAKMIP2	Q96AA8	MRPL11	Homo sapiens	Q9Y3B7	Y2H Array	25416956
Intra	JAKMIP2	Q96AA8	CLIP4	Homo sapiens	Q8N3C7	Y2H Prey Pooling	32296183
Intra	JAKMIP2	Q96AA8	CLIP4	Homo sapiens	Q8N3C7	Y2H Array	32296183
Intra	JAKMIP2	Q96AA8	CLIP4	Homo sapiens	Q8N3C7	Y2H Prey Pooling	25416956
Intra	JAKMIP2	Q96AA8	PIN1	Homo sapiens	Q13526	Y2H Array	31515488
Intra	JAKMIP2	Q96AA8	PIN1	Homo sapiens	Q13526	Validated Y2H	25416956
Intra	JAKMIP2	Q96AA8	HGS	Homo sapiens	O14964	Y2H Prey Pooling	25416956
Intra	JAKMIP2	Q96AA8	HGS	Homo sapiens	O14964	Validated Y2H	25416956
Intra	JAKMIP2	Q96AA8	ELOA	Homo sapiens	Q14241	Y2H Prey Pooling	25416956
Intra	JAKMIP2	Q96AA8	ELOA	Homo sapiens	Q14241	Validated Y2H	25416956
Intra	JAKMIP2	Q96AA8	ZNF263	Homo sapiens	O14978	Y2H Array	32296183
Intra	JAKMIP2	Q96AA8	ZNF263	Homo sapiens	O14978	Y2H Prey Pooling	32296183
Intra	JAKMIP2	Q96AA8	NAB2	Homo sapiens	Q15742	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07025	JAKMIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	JAKMIP2	VGNC	VGNC:73926
Mus musculus	JAKMIP2	MGD	MGI:1923467
Bos taurus	JAKMIP2	VGNC	VGNC:30368
Canis familiaris	JAKMIP2	VGNC	VGNC:42178
Felis catus	JAKMIP2	VGNC	VGNC:62999
Rattus norvegicus	JAKMIP2	RGD	RGD:1559742

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