SF3A1 - splicing factor 3a subunit 1 Gene

Homo sapiens

Also known as PRP21; PRPF21; SAP114; SF3A120

Gene ID: 10291 | Gene type: protein coding

About SF3A1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,331,988-30,356,894 (from NCBI)

This gene has 10 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 34.4), ovary (RPKM 24.5) and 25 other tissues.

Summary

This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014]

SF3A1 Products(1)

mRNA	Protein	Name
NM_005877.6	NP_005868.1	splicing factor 3A subunit 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	10882114	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10976766	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in U2-type prespliceosome assembly	IDA IDA: Inferred from direct assay	10882114	GOA
involved in mRNA processing	IMP IMP: Inferred from mutant phenotype	15647371	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	10882114	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2 snRNP	IDA IDA: Inferred from direct assay	10882114	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	10882114	GOA
part of U2-type prespliceosome	IDA IDA: Inferred from direct assay	10882114	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	10882114	GOA
part of U2-type spliceosomal complex	IPI IPI: Inferred from physical interaction	10882114	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	21349847	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10882114	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	9731529	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SF3A1 Protein Structure

Surp

PRP21_like_P

ubiquitin

0
200
400
600
793 a.a.

Protein Preferred Names

Protein Names

splicing factor 3A subunit 1

SAP 114

SF3A1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SF3A1	Q15459	SF3A3	Homo sapiens	Q12874	Anti Tag CoIP	33961781
Intra	SF3A1	Q15459	SF3A3	Homo sapiens	Q12874	Anti Tag CoIP	28514442
Intra	SF3A1	Q15459	SF3A3	Homo sapiens	Q12874	Anti Tag CoIP	22365833
Intra	SF3A1	Q15459	SF3A3	Homo sapiens	Q12874	Y2H	22365833
Intra	SF3A1	Q15459	SF3A3	Homo sapiens	Q12874	Anti Tag CoIP	35271311
Intra	SF3A1	Q15459	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	22365833
Intra	SF3A1	Q15459	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	35271311
Intra	SF3A1	Q15459	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	SF3A1	Q15459	SP1	Homo sapiens	P08047	Y2H	10976766
Intra	SF3A1	Q15459	PRPF40A	Homo sapiens	O75400	Anti Tag CoIP	35271311
Intra	SF3A1	Q15459	RBM10	Homo sapiens	P98175	Y2H	22365833
Intra	SF3A1	Q15459	SF1	Homo sapiens	Q15637	Pull Down	26420826
Intra	SF3A1	Q15459	SF1	Homo sapiens	Q15637	Y2H	22365833
Intra	SF3A1	Q15459	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 61

RP61	Retinitis Pigmentosa, Type 61

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-111517	H3B-8800		98.85%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16399	Pladienolide B		99.20%	Unkown
HY-141881	PROTAC-O4I2		99.66%	Unkown
HY-16466	Spliceostatin A		95.09%	Unkown
HY-146221	Dyrk1A-IN-5	Inhibitor	98.56%	Unkown
HY-162386	UM4118	Inducer	99.95%	Unkown
HY-170368	3′-Me Meayamycin D	Modulator	/	Unkown
HY-RS12757	SF3A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12760	SF3B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-158783	SACLAC		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SF3A1	VGNC	VGNC:65052
Bos taurus	SF3A1	VGNC	VGNC:34506
Rattus norvegicus	SF3A1	RGD	RGD:1311477
Mus musculus	SF3A1	MGD	MGI:1914715
Canis familiaris	SF3A1	VGNC	VGNC:46067
Macaca mulatta	SF3A1	VGNC	VGNC:77177

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