2. Gene
  3. SF3A1 - splicing factor 3a subunit 1 Gene

SF3A1 - splicing factor 3a subunit 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PRP21; PRPF21; SAP114; SF3A120

Gene ID: 10291 | Gene type: protein coding

About SF3A1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,331,988-30,356,894 (from NCBI)

This gene has 10 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 34.4), ovary (RPKM 24.5) and 25 other tissues.

Summary

This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014]

SF3A1 Products(1)

mRNA Protein Name
NM_005877.6 NP_005868.1 splicing factor 3A subunit 1

SF3A1 Protein Structure

Surp

Surp: Surp module (50 - 102)

Surp

Surp: Surp module (163 - 215)

PRP21_like_P

PRP21_like_P: Pre-mRNA splicing factor PRP21 like protein (226 - 472)

ubiquitin

ubiquitin: Ubiquitin family (722 - 788)

  • 0
  • 200
  • 400
  • 600
  • 793 a.a.
Protein Preferred Names Protein Names

splicing factor 3A subunit 1

SAP 114

Related Diseases

Diseases Alias
Retinitis Pigmentosa 61

RP61

Retinitis Pigmentosa, Type 61
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-111517 H3B-8800 98.18% Phase 1
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16399 Pladienolide B ≥99.0% Unkown
HY-141881 PROTAC-O4I2 99.66% Unkown
HY-16466 Spliceostatin A 95.09% Unkown
HY-146221 Dyrk1A-IN-5 Inhibitor 98.56% Unkown
HY-162386 UM4118 Inducer 99.95% Unkown
HY-RS12757 SF3A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12760 SF3B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-158783 SACLAC / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SF3A1 VGNC VGNC:65052
Bos taurus SF3A1 VGNC VGNC:34506
Rattus norvegicus SF3A1 RGD RGD:1311477
Mus musculus SF3A1 MGD MGI:1914715
Canis familiaris SF3A1 VGNC VGNC:46067
Macaca mulatta SF3A1 VGNC VGNC:77177