2. Gene
  3. RBM10 - RNA binding motif protein 10 Gene

RBM10 - RNA binding motif protein 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as S1-1; TARPS; GPATC9; ZRANB5; GPATCH9; DXS8237E; MINAS-60

Gene ID: 8241 | Gene type: protein coding

About RBM10

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,145,221-47,186,813 (from NCBI)

This gene has 6 transcripts (splice variants), 186 orthologues, 2 paralogues and is associated with 102 phenotypes. Ubiquitous expression in ovary (RPKM 15.6), spleen (RPKM 12.3) and 25 other tissues.

Summary

This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

RBM10 Products(5)

mRNA Protein Name
NM_001204466.2 NP_001191395.1 RNA-binding protein 10 isoform 3
NM_001204467.2 NP_001191396.1 RNA-binding protein 10 isoform 4
NM_001204468.2 NP_001191397.1 RNA-binding protein 10 isoform 5
NM_005676.5 NP_005667.2 RNA-binding protein 10 isoform 1
NM_152856.3 NP_690595.1 RNA-binding protein 10 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
enables miRNA binding IDA
IDA: Inferred from direct assay
28431233 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of ribosomal large subunit export from nucleus IDA
IDA: Inferred from direct assay
35393574 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in nucleolus IDA
IDA: Inferred from direct assay
35393574 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28091594 GOA
part of protein-containing complex IPI
IPI: Inferred from physical interaction
17707232 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM10 Protein Structure

(131 - 201)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (215 - 241)

(302 - 378)

G-patch

G-patch: G-patch domain (859 - 902)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 930 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 10

G-patch domain containing 9

RBM10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RBM10 P98175 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
32296183
Intra RBM10 P98175 BEND7 Homo sapiens Q8N7W2-2
Validated Y2H
32296183
Intra RBM10 P98175 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
32296183
Intra RBM10 P98175 SF3A1 Homo sapiens Q15459
Anti Tag CoIP
22365833
Intra RBM10 P98175 PATZ1 Homo sapiens Q9HBE1-4
Y2H Prey Pooling
32296183
Intra RBM10 P98175 PATZ1 Homo sapiens Q9HBE1-4
Validated Y2H
32296183
Intra RBM10 P98175 PATZ1 Homo sapiens Q9HBE1-4
Y2H Array
32296183
Intra RBM10 P98175 ZNF526 Homo sapiens Q8TF50
Y2H Prey Pooling
32296183
Intra RBM10 P98175 ZNF526 Homo sapiens Q8TF50
Validated Y2H
32296183
Intra RBM10 P98175 ZNF526 Homo sapiens Q8TF50
Y2H Array
32296183
Intra RBM10 P98175 CPSF7 Homo sapiens Q8N684-3
Y2H Prey Pooling
32296183
Intra RBM10 P98175 CPSF7 Homo sapiens Q8N684-3
Validated Y2H
26871637
Intra RBM10 P98175 CPSF7 Homo sapiens Q8N684-3
Validated Y2H
32296183
Intra RBM10 P98175 CPSF7 Homo sapiens Q8N684-3
Y2H Array
26871637
Intra RBM10 P98175 CPSF7 Homo sapiens Q8N684-3
Y2H Array
32296183
Intra RBM10 P98175 CPSF7 Homo sapiens Q8N684-3
Y2H Prey Pooling
26871637
Intra RBM10 P98175 ZNF317 Homo sapiens Q96PQ6
Validated Y2H
32296183
Intra RBM10 P98175 ZNF317 Homo sapiens Q96PQ6
Y2H Array
32296183
Intra RBM10 P98175 ZNF317 Homo sapiens Q96PQ6
Y2H Prey Pooling
32296183
Intra RBM10 P98175 PTBP2 Homo sapiens Q9UKA9-2
Validated Y2H
26871637
Intra RBM10 P98175 PTBP2 Homo sapiens Q9UKA9-2
Y2H Array
26871637
Intra RBM10 P98175 PTBP2 Homo sapiens Q9UKA9-2
Y2H Prey Pooling
26871637
Intra RBM10 P98175 DHX15 Homo sapiens O43143
Y2H
22365833
Intra RBM10 P98175 DHX15 Homo sapiens O43143
Anti Tag CoIP
22365833
Intra RBM10 P98175 PRR20E Homo sapiens P86478
Y2H Prey Pooling
26871637
Intra RBM10 P98175 PRR20E Homo sapiens P86478
Validated Y2H
26871637
Intra RBM10 P98175 PRR20E Homo sapiens P86478
Y2H Array
26871637
Intra RBM10 P98175 PTBP1 Homo sapiens P26599-3
Validated Y2H
26871637
Intra RBM10 P98175 PTBP1 Homo sapiens P26599-3
Y2H Array
26871637
Intra RBM10 P98175 PTBP1 Homo sapiens P26599-3
Y2H Prey Pooling
26871637
Intra RBM10 P98175 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
26871637
Intra RBM10 P98175 MEOX2 Homo sapiens Q6FHY5
Y2H Array
26871637
Intra RBM10 P98175 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
26871637
Intra RBM10 P98175 ZNF275 Homo sapiens Q9NSD4
Y2H Prey Pooling
32296183
Intra RBM10 P98175 ZNF275 Homo sapiens Q9NSD4
Validated Y2H
32296183
Intra RBM10 P98175 ZNF275 Homo sapiens Q9NSD4
Y2H Array
32296183
Intra RBM10 P98175 SUGP1 Homo sapiens Q8IWZ8
Y2H
22365833
Intra RBM10 P98175 CBLL1 Homo sapiens Q75N03
Validated Y2H
26871637
Intra RBM10 P98175 CBLL1 Homo sapiens Q75N03
Y2H Array
26871637
Intra RBM10 P98175 CBLL1 Homo sapiens Q75N03
Y2H Prey Pooling
26871637
Intra RBM10 P98175 U2SURP Homo sapiens O15042
Anti Tag CoIP
22365833
Intra RBM10 P98175 U2SURP Homo sapiens O15042
Y2H
22365833
Intra RBM10 P98175 ZNF408 Homo sapiens Q9H9D4
Y2H Prey Pooling
32296183
Intra RBM10 P98175 ZNF408 Homo sapiens Q9H9D4
Validated Y2H
32296183
Intra RBM10 P98175 ZNF408 Homo sapiens Q9H9D4
Y2H Array
32296183
Intra RBM10 P98175 SF3B4 Homo sapiens Q15427
Y2H
22365833
Intra RBM10 P98175 SF3B4 Homo sapiens Q15427
Validated Y2H
26871637
Intra RBM10 P98175 SF3B4 Homo sapiens Q15427
Validated Y2H
32296183
Intra RBM10 P98175 SF3B4 Homo sapiens Q15427
Y2H Prey Pooling
26871637
Intra RBM10 P98175 SF3B4 Homo sapiens Q15427
Y2H Array
26871637
Intra RBM10 P98175 SF3B4 Homo sapiens Q15427
Y2H Array
32296183
Intra RBM10 P98175 SF3B4 Homo sapiens Q15427
Y2H Prey Pooling
32296183
Intra RBM10 P98175 PTBP1 Homo sapiens P26599
Validated Y2H
26871637
Intra RBM10 P98175 PTBP1 Homo sapiens P26599
Y2H Prey Pooling
26871637
Intra RBM10 P98175 PTBP1 Homo sapiens P26599
Y2H Array
26871637
Intra RBM10 P98175 CCAR1 Homo sapiens Q8IX12
Y2H
22365833
Intra RBM10 P98175 CCAR1 Homo sapiens Q8IX12
Anti Tag CoIP
35271311
Intra RBM10 P98175 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra RBM10 P98175 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra RBM10 P98175 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra RBM10 P98175 PRPF19 Homo sapiens Q9UMS4
Anti Tag CoIP
22365833
Intra RBM10 P98175 PRPF19 Homo sapiens Q9UMS4
Y2H
22365833
Intra RBM10 P98175 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
26871637
Intra RBM10 P98175 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
32296183
Intra RBM10 P98175 PRDM14 Homo sapiens Q9GZV8
Y2H Array
26871637
Intra RBM10 P98175 PRDM14 Homo sapiens Q9GZV8
Y2H Array
32296183
Intra RBM10 P98175 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
26871637
Intra RBM10 P98175 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
32296183
Intra RBM10 P98175 ZFP64 Homo sapiens Q9NTW7
Y2H Array
26871637
Intra RBM10 P98175 ZFP64 Homo sapiens Q9NTW7
Y2H Prey Pooling
26871637
Intra RBM10 P98175 ZFP64 Homo sapiens Q9NTW7
Validated Y2H
26871637
Intra RBM10 P98175 TLE5 Homo sapiens Q08117
Y2H Array
25416956
Intra RBM10 P98175 MBD6 Homo sapiens Q96DN6
Validated Y2H
32296183
Intra RBM10 P98175 MBD6 Homo sapiens Q96DN6
Y2H Array
32296183
Intra RBM10 P98175 MBD6 Homo sapiens Q96DN6
Y2H Prey Pooling
32296183
Intra RBM10 P98175 ccsb orf id: 2129 Homo sapiens EBI-16432778
Y2H Prey Pooling
32296183
Intra RBM10 P98175 ccsb orf id: 2129 Homo sapiens EBI-16432778
Validated Y2H
26871637
Intra RBM10 P98175 ccsb orf id: 2129 Homo sapiens EBI-16432778
Y2H Array
26871637
Intra RBM10 P98175 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
26871637
Intra RBM10 P98175 ccsb orf id: 2129 Homo sapiens EBI-16432778
Y2H Array
32296183
Intra RBM10 P98175 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra RBM10 P98175 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
26871637
Intra RBM10 P98175 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra RBM10 P98175 CEP70 Homo sapiens Q8NHQ1
Y2H Array
26871637
Intra RBM10 P98175 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra RBM10 P98175 ccsb orf id: 2129 Homo sapiens EBI-16432778
Y2H Prey Pooling
26871637
Intra RBM10 P98175 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
26871637
Intra RBM10 P98175 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
32296183
Intra RBM10 P98175 THAP1 Homo sapiens Q9NVV9
Validated Y2H
26871637
Intra RBM10 P98175 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra RBM10 P98175 THAP1 Homo sapiens Q9NVV9
Y2H Array
26871637
Intra RBM10 P98175 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra RBM10 P98175 U2AF2 Homo sapiens P26368
Y2H
22365833
Intra RBM10 P98175 BAHD1 Homo sapiens Q8TBE0
Validated Y2H
32296183
Intra RBM10 P98175 BAHD1 Homo sapiens Q8TBE0
Y2H Array
32296183
Intra RBM10 P98175 BAHD1 Homo sapiens Q8TBE0
Y2H Prey Pooling
32296183
Intra RBM10 P98175 KHDRBS2 Homo sapiens Q5VWX1
Validated Y2H
26871637
Intra RBM10 P98175 KHDRBS2 Homo sapiens Q5VWX1
Y2H Array
26871637
Intra RBM10 P98175 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
26871637
Intra RBM10 P98175 ZBTB24 Homo sapiens O43167
Y2H Prey Pooling
26871637
Intra RBM10 P98175 ZBTB24 Homo sapiens O43167
Validated Y2H
26871637
Intra RBM10 P98175 ZBTB24 Homo sapiens O43167
Y2H Array
26871637
Intra RBM10 P98175 DDX17 Homo sapiens Q92841
Validated Y2H
26871637
Intra RBM10 P98175 DDX17 Homo sapiens Q92841
Validated Y2H
32296183
Intra RBM10 P98175 DDX17 Homo sapiens Q92841
Y2H Array
26871637
Intra RBM10 P98175 DDX17 Homo sapiens Q92841
Y2H Array
32296183
Intra RBM10 P98175 DDX17 Homo sapiens Q92841
Y2H Prey Pooling
26871637
Intra RBM10 P98175 DDX17 Homo sapiens Q92841
Y2H Prey Pooling
32296183
Intra RBM10 P98175 GPKOW Homo sapiens Q92917
Y2H
22365833
Intra RBM10 P98175 ZNF473 Homo sapiens Q8WTR7
Validated Y2H
26871637
Intra RBM10 P98175 ZNF473 Homo sapiens Q8WTR7
Y2H Array
26871637
Intra RBM10 P98175 ZNF473 Homo sapiens Q8WTR7
Y2H Prey Pooling
26871637
Intra RBM10 P98175 SNRPC Homo sapiens P09234
Y2H
22365833
Intra RBM10 P98175 KLF1 Homo sapiens Q13351
Y2H Prey Pooling
32296183
Intra RBM10 P98175 KLF1 Homo sapiens Q13351
Validated Y2H
32296183
Intra RBM10 P98175 KLF1 Homo sapiens Q13351
Y2H Array
32296183
Intra RBM10 P98175 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
26871637
Intra RBM10 P98175 RBMY1F Homo sapiens Q15415
Validated Y2H
26871637
Intra RBM10 P98175 RBMY1F Homo sapiens Q15415
Y2H Array
26871637
Intra RBM10 P98175 TBC1D22B Homo sapiens Q9NU19
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tarp Syndrome

TARPS

Pierre Robin Syndrome With Congenital Heart Malformation And Clubfoot

Pierre Robin Sequence-Congenital Heart Defect-Talipes Syndrome

Pierre Robin Syndrome-Congenital Heart Defect-Talipes Syndrome

Talipes Equinovarus-Atrial Septal Defect-Robin Sequence-Persistence Of The Left Superior Vena Cava Syndrome

Talipes Equinovarus, Atrial Septal Defect, Robin Sequence, And Persistence Of Left Superior Vena Cava

Pierre Robin Sequence - Congenital Heart Defect - Talipes

Pierre Robin Syndrome - Congenital Heart Defect - Talipes

Talipes Equinovarus - Atrial Septal Defect - Robin Sequence - Persistence Of The Left Superior Vena Cava

Talipes Equinovarus Atrial Septal Defect Robin Sequence And Persistence Of Left Superior Vena Cava
Pierre Robin Syndrome

Pierre Robin Sequence

Glossoptosis, Micrognathia, And Cleft Palate

Pierre Robin Syndrome Skeletal Dysplasia Polydactyly

Pierre-Robin Syndrome

Isolated Pierre Robin Sequence

Isolated Pierre-Robin Syndrome

PRBNS

Robin Sequence

Robin Syndrome

Isolated Pierre Robin Syndrome
Skin Angiosarcoma

Angiosarcoma Of Skin

Hemangiosarcoma Of The Skin

Haemangiosarcoma Of Skin

Lymphangiosarcoma Of Skin

Cutaneous Angiosarcoma

Malignant Haemangioendothelioma Of Skin
Talipes Equinovarus

Congenital Equinovarus

Congenital Talipes Equinovarus

Equinovarus

Congenital Varus Clubfoot
Treacher Collins Syndrome 1

Treacher Collins Syndrome

Mandibulofacial Dysostosis

Treacher Collins-Franceschetti Syndrome

Tcof

Tcs

Mfd1

Franceschetti-Klein Syndrome

TCS1

Franceschetti Syndrome

Franceschetti-Zwahlen-Klein Syndrome

Zygoauromandibular Dysplasia

Treacher-Collins Syndrome

Mandibulofacial Dysostosis Without Limb Anomalies

Bilateral And Symmetric Oto-Mandibular Dysplasia
Atrial Heart Septal Defect

Atrial Septal Defect

Atrial Septal Defects

Atrioseptal Defect

Auricular Septal Defect

Congenital Atrial Septal Defect

Interatrial Septal Defect

Interauricular Septal Defect

Heart Septal Defects, Atrial

Septal Defect, Atrial
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-142032 RBM10-8 Inhibitor / Unkown
HY-RS11731 RBM10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RBM10 VGNC VGNC:33783
Macaca mulatta RBM10 VGNC VGNC:76680
Felis catus RBM10 VGNC VGNC:69262
Mus musculus RBM10 MGD MGI:2384310
Rattus norvegicus RBM10 RGD RGD:631366
Canis familiaris RBM10 VGNC VGNC:45404