ZNHIT1 - zinc finger HIT-type containing 1 Gene

Homo sapiens

Also known as CG1I; ZNFN4A1

Gene ID: 10467 | Gene type: protein coding

About ZNHIT1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,218,165-101,224,190 (from NCBI)

This gene has 4 transcripts (splice variants) and 179 orthologues. Ubiquitous expression in liver (RPKM 23.5), kidney (RPKM 21.2) and 25 other tissues.

Summary

Predicted to enable histone deacetylase binding activity and nucleosome binding activity. Predicted to be involved in histone exchange. Predicted to act upstream of or within several processes, including negative regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; and regulation of histone deacetylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNHIT1 Products(1)

mRNA	Protein	Name
NM_006349.3	NP_006340.1	zinc finger HIT domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone binding	IPI IPI: Inferred from physical interaction	20473270	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15647280	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	20473270	GOA
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA IDA: Inferred from direct assay	17700068	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	17892483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNHIT1 Protein Structure

zf-HIT

0
100
154 a.a.

Protein Preferred Names

Protein Names

zinc finger HIT domain-containing protein 1

H_DJ0747G18.14

ZNHIT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNHIT1	O43257	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	ZNHIT1	O43257	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	ZNHIT1	O43257	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	ZNHIT1	O43257	KRTAP12-2	Homo sapiens	P59991	Validated Y2H	32296183
Intra	ZNHIT1	O43257	KRTAP12-2	Homo sapiens	P59991	Y2H Array	32296183
Intra	ZNHIT1	O43257	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	32296183
Intra	ZNHIT1	O43257	H2AZ1	Homo sapiens	P0C0S5	Anti Bait CoIP	20473270
Intra	ZNHIT1	O43257	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	ZNHIT1	O43257	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	ZNHIT1	O43257	KRTAP10-6	Homo sapiens	P60371	Validated Y2H	32296183
Intra	ZNHIT1	O43257	MYO5B	Homo sapiens	Q9ULV0-2	Validated Y2H	32296183
Intra	ZNHIT1	O43257	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	ZNHIT1	O43257	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	ZNHIT1	O43257	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	ZNHIT1	O43257	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	ZNHIT1	O43257	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	ZNHIT1	O43257	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	ZNHIT1	O43257	TP53BP1	Homo sapiens	Q12888	Pull Down	17380123
Intra	ZNHIT1	O43257	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	ZNHIT1	O43257	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	ZNHIT1	O43257	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	ZNHIT1	O43257	EEF1D	Homo sapiens	P29692-2	Validated Y2H	32814053
Intra	ZNHIT1	O43257	EEF1D	Homo sapiens	P29692-2	Y2H Array	32814053
Intra	ZNHIT1	O43257	EEF1D	Homo sapiens	P29692-2	Y2H Pooling	32814053
Intra	ZNHIT1	O43257	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	ZNHIT1	O43257	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	ZNHIT1	O43257	DNM1L	Homo sapiens	O00429-3	Y2H Pooling	32814053
Intra	ZNHIT1	O43257	DNM1L	Homo sapiens	O00429-3	Validated Y2H	32814053
Intra	ZNHIT1	O43257	DNM1L	Homo sapiens	O00429-3	Y2H Array	32814053
Intra	ZNHIT1	O43257	MAPK9	Homo sapiens	P45984	Validated Y2H	32296183
Intra	ZNHIT1	O43257	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	ZNHIT1	O43257	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	ZNHIT1	O43257	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	ZNHIT1	O43257	MAPK14	Homo sapiens	Q16539	Anti Tag CoIP	17380123
Intra	ZNHIT1	O43257	COL8A1	Homo sapiens	P27658	Validated Y2H	32296183
Intra	ZNHIT1	O43257	FHL5	Homo sapiens	Q5TD97	Validated Y2H	32296183
Intra	ZNHIT1	O43257	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	ZNHIT1	O43257	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	ZNHIT1	O43257	BCL6	Homo sapiens	P41182	Validated Y2H	32296183
Intra	ZNHIT1	O43257	ACTR6	Homo sapiens	Q9GZN1	Anti Bait CoIP	16230350
Intra	ZNHIT1	O43257	ACTR6	Homo sapiens	Q9GZN1	Anti Tag CoIP	33961781
Intra	ZNHIT1	O43257	ACTR6	Homo sapiens	Q9GZN1	Anti Tag CoIP	15647280
Intra	ZNHIT1	O43257	ACTR6	Homo sapiens	Q9GZN1	Anti Bait CoIP	20473270
Intra	ZNHIT1	O43257	OTX2	Homo sapiens	P32243-2	Validated Y2H	32296183
Intra	ZNHIT1	O43257	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183
Intra	ZNHIT1	O43257	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ZNHIT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71028	ZNHIT1 Protein, Human (His)	O43257 (M1-V154)	≥95%

Related Diseases

Diseases

Alias

Floating-Harbor Syndrome

FLHS	Fhs
Pelletier-Leisti Syndrome	Short Stature With Delayed Bone Age, Expressive Language Delay, A Triangular Face With A Prominent Nose And Deep-Set Eyes
Leisti-Hollander-Rimoin Syndrome

Hemophagocytic Lymphohistiocytosis, Familial, 1

Familial Hemophagocytic Lymphohistiocytosis	Fhl
Familial Erythrophagocytic Lymphohistiocytosis	Hemophagocytic Syndrome
FHL1	Hplh1
Hlh1	Fel
Familial Hemophagocytic Lymphohistiocytosis 1	Primary Hemophagocytic Lymphohistiocytosis
Familial Hlh	Hlh
Familial Hemophagocytic Lymphocytosis	Hemophagocytic Lymphohistiocytosis, Familial
Reticulosis, Familial Histiocytic	Hemophagocytic Reticulosis, Familial
Erythrophagocytic Lymphohistiocytosis, Familial	Familial Histiocytic Reticulosis
Familial Hemophagocytic Histiocytosis	Familial Hemophagocytic Reticulosis
Fhlh	Hplh
Primary Hemophagocytic Hymphohistiocytosis	Genetic Hemophagocytic Lymphohistiocytosis
Hemophagocytic Lymphohistiocytosis	Familial Hemophagocytic Lymphohistiocytosis Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16181	ZNHIT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZNHIT1	VGNC	VGNC:48835
Felis catus	ZNHIT1	VGNC	VGNC:67366
Macaca mulatta	ZNHIT1	VGNC	VGNC:79332
Bos taurus	ZNHIT1	VGNC	VGNC:37358
Mus musculus	ZNHIT1	MGD	MGI:1917353
Rattus norvegicus	ZNHIT1	RGD	RGD:2322870
Others	ZNHIT1	NCBI

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