1. Gene
  2. TP53BP1 - tumor protein p53 binding protein 1 Gene

TP53BP1 - tumor protein p53 binding protein 1 Gene

Homo sapiens

Also known as p202; 53BP1; TDRD30; p53BP1

Gene ID: 7158 | Gene type: protein coding

About TP53BP1

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,403,061-43,510,640 (from NCBI)

This gene has 17 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in brain (RPKM 10.8), testis (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

TP53BP1 Products(5)

mRNA Protein Name
NM_001141979.3 NP_001135451.1 TP53-binding protein 1 isoform 2
NM_001141980.3 NP_001135452.1 TP53-binding protein 1 isoform 1
NM_001355001.2 NP_001341930.1 TP53-binding protein 1 isoform 4
NM_001411050.1 NP_001397979.1 TP53-binding protein 1 isoform 5
NM_005657.4 NP_005648.1 TP53-binding protein 1 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
17805299 GOA
enables histone reader activity IDA
IDA: Inferred from direct assay
23760478 GOA
enables methylated histone binding IDA
IDA: Inferred from direct assay
22373579 GOA
enables p53 binding IPI
IPI: Inferred from physical interaction
14985081 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11877378 GOA
enables transcription coregulator activity IMP
IMP: Inferred from mutant phenotype
17805299 GOA
enables ubiquitin-modified histone reader activity IDA
IDA: Inferred from direct assay
22492721 GOA
Cellular Component GO Annotation Evidence Reference Source
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
15149599 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
9748285 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28241136 GOA
is active in site of double-strand break IDA
IDA: Inferred from direct assay
22492721 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
23333306 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53BP1 Protein Structure

53-BP1_Tudor

53-BP1_Tudor: Tumour suppressor p53-binding protein-1 Tudor (1488 - 1609)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1977 a.a.
Protein Preferred Names Protein Names

TP53-binding protein 1

p53-binding protein 1

TP53BP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TP53BP1 Q12888 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
TP53BP1 Q12888 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
TP53BP1 Q12888 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
TP53BP1 Q12888 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
TP53BP1 Q12888 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
TP53BP1 Q12888 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
TP53BP1 Q12888 ANKS1A Homo sapiens Q49AR9
Validated Y2H
32296183
Intra
TP53BP1 Q12888 VAMP1 Homo sapiens P23763-3
Validated Y2H
32814053
Intra
TP53BP1 Q12888 VAMP1 Homo sapiens P23763-3
Y2H Pooling
32814053
Intra
TP53BP1 Q12888 VAMP1 Homo sapiens P23763-3
Y2H Array
32814053
Intra
TP53BP1 Q12888 C10orf55 Homo sapiens Q5SWW7
Validated Y2H
32296183
Intra
TP53BP1 Q12888 C10orf55 Homo sapiens Q5SWW7
Y2H Prey Pooling
32296183
Intra
TP53BP1 Q12888 C10orf55 Homo sapiens Q5SWW7
Y2H Array
32296183
Intra
TP53BP1 Q12888 OXER1 Homo sapiens Q8TDS5
Validated Y2H
32296183
Intra
TP53BP1 Q12888 OXER1 Homo sapiens Q8TDS5
Y2H Array
32296183
Intra
TP53BP1 Q12888 OXER1 Homo sapiens Q8TDS5
Y2H Prey Pooling
32296183
Cross
TP53BP1 Q12888 Paxip1 Mus musculus Q6NZQ4
Anti Tag CoIP
19124460
Intra
TP53BP1 Q12888 VRK1 Homo sapiens Q99986
Pull Down
22621922
Intra
TP53BP1 Q12888 VRK1 Homo sapiens Q99986
Phosphotransferase
22621922
Intra
TP53BP1 Q12888 SHLD2 Homo sapiens Q86V20-2
Anti Tag CoIP
29789392
Intra
TP53BP1 Q12888 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
TP53BP1 Q12888 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra
TP53BP1 Q12888 UBAP2 Homo sapiens Q5T6F2
Validated Y2H
32296183
Intra
TP53BP1 Q12888 UBAP2 Homo sapiens Q5T6F2
Y2H Prey Pooling
32296183
Intra
TP53BP1 Q12888 UBAP2 Homo sapiens Q5T6F2
Y2H Array
32296183
Intra
TP53BP1 Q12888 H4C16 Homo sapiens P62805
Far-WB
16415788
Intra
TP53BP1 Q12888 H4C16 Homo sapiens P62805
Pull Down
16415788
Intra
TP53BP1 Q12888 H4C16 Homo sapiens P62805
Pull Down
22373579
Intra
TP53BP1 Q12888 H4C16 Homo sapiens P62805
Pull Down
27153538
Intra
TP53BP1 Q12888 H4C16 Homo sapiens P62805
SPR
16415788
Intra
TP53BP1 Q12888 ZNHIT1 Homo sapiens O43257
Anti Bait CoIP
17380123
Intra
TP53BP1 Q12888 BRCA1 Homo sapiens P38398
Confocal
18001824
Intra
TP53BP1 Q12888 BRCA1 Homo sapiens P38398
BioID
29656893
Intra
TP53BP1 Q12888 VIM Homo sapiens P08670
Y2H Array
32814053
Intra
TP53BP1 Q12888 VIM Homo sapiens P08670
Y2H Pooling
32814053
Intra
TP53BP1 Q12888 VIM Homo sapiens P08670
Validated Y2H
32814053
Intra
TP53BP1 Q12888 H2BC10 Homo sapiens P62807
Crosslink
27462807
Intra
TP53BP1 Q12888 H2BC10 Homo sapiens P62807
Pull Down
27462807
Intra
TP53BP1 Q12888 TP53 Homo sapiens P04637
Anti Bait CoIP
17805299
Intra
TP53BP1 Q12888 PLK1 Homo sapiens P53350
Protein Kinase Assay
20126263
Intra
TP53BP1 Q12888 PLK1 Homo sapiens P53350
Pull Down
20126263
Intra
TP53BP1 Q12888 PLK1 Homo sapiens P53350
Anti Bait CoIP
20126263
Intra
TP53BP1 Q12888 H2AX Homo sapiens P16104
IF
18001825
Intra
TP53BP1 Q12888 H2AX Homo sapiens P16104
IF
20075863
Intra
TP53BP1 Q12888 H2AX Homo sapiens P16104
Imaging
17024177
Intra
TP53BP1 Q12888 H2AX Homo sapiens P16104
Pull Down
12607005
Intra
TP53BP1 Q12888 ATM Homo sapiens Q13315
BioID
29656893
Intra
TP53BP1 Q12888 ATM Homo sapiens Q13315
Phosphotransferase
22621922
Intra
TP53BP1 Q12888 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
TP53BP1 Q12888 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
TP53BP1 Q12888 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
TP53BP1 Q12888 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
TP53BP1 Q12888 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
TP53BP1 Q12888 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
TP53BP1 Q12888 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
TP53BP1 Q12888 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
TP53BP1 Q12888 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
TP53BP1 Q12888 PAXIP1 Homo sapiens Q6ZW49
Anti Tag CoIP
15456759
Intra
TP53BP1 Q12888 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
TP53BP1 Q12888 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
TP53BP1 Q12888 NCOA6 Homo sapiens Q14686
Anti Bait CoIP
19433796
Intra
TP53BP1 Q12888 H3C1 Homo sapiens P68431
Far-WB
16415788
Intra
TP53BP1 Q12888 H3C1 Homo sapiens P68431
Pull Down
16415788
Intra
TP53BP1 Q12888 H3C1 Homo sapiens P68431
SPR
16415788
Intra
TP53BP1 Q12888 H3C1 Homo sapiens P68431
Protein Array
16415788
Intra
TP53BP1 Q12888 KLHDC7B Homo sapiens Q96G42
Y2H Array
32296183
Intra
TP53BP1 Q12888 KLHDC7B Homo sapiens Q96G42
Y2H Prey Pooling
32296183
Intra
TP53BP1 Q12888 KLHDC7B Homo sapiens Q96G42
Validated Y2H
32296183
Intra
TP53BP1 Q12888 ATP1A3 Homo sapiens P13637
Validated Y2H
32814053
Intra
TP53BP1 Q12888 ATP1A3 Homo sapiens P13637
Y2H Array
32814053
Intra
TP53BP1 Q12888 ATP1A3 Homo sapiens P13637
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microcephaly And Chorioretinopathy 3
Microcephaly And Chorioretinopathy, Autosomal Recessive, 3

MCCRP3

Microcephaly And Chorioretinopathy, Autosomal Recessive, Type 3

Microcephaly Chorioretinopathy Recessive Form
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome

Autosomal Recessive Chorioretinopathy-Microcephaly-Intellectual Disability Syndrome

Riddle Syndrome

RIDL

Radiosensitivity-Immunodeficiency-Dysmorphic Features-Learning Difficulties Syndrome

Rnf168 Deficiency

Radiosensitivity, Immunodeficiency, Dysmorphic Facial Features, And Learning Difficulties

Radiosensitivity, Immunodeficiency, Dysmorphic Features, And Learning Difficulties

Ataxia-Telangiectasia

Ataxia Telangiectasia

Louis-Bar Syndrome

AT

At1

Ataxia-Telangiectasia Syndrome

Ataxia - Telangiectasia Variant

Boder-Sedgwick Syndrome

Louis Bar Syndrome

Cerebello-Oculocutaneous Telangiectasia

Immunodeficiency With Ataxia Telangiectasia

A-T

Ataxia Telangiectasia Syndrome

Atm

Telangiectasia, Cerebello-Oculocutaneous

Ataxia-Telangiectasia Variant

Myeloproliferative Disorder, Chronic, With Eosinophilia

Myeloproliferative Disorder With Eosinophilia

MPE

Emp

Eosinophils, Malignant Proliferation Of

Chronic Myeloproliferative Disorder With Eosinophilia

Chronic Myeloproliferative Disease, Unclassifiable

Cmpd-U

Undifferentiated Myeloproliferative Disease

Myeloproliferative Disorder Chronic With Eosinophilia

Malignant Proliferation Of Eosinophils

Myeloproliferative Neoplasm, Unclassifiable

Autosomal Recessive Cerebellar Ataxia

Arca

Lig4 Syndrome

Dna Ligase Iv Deficiency

Ligase 4 Syndrome

LIG4S

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum

Seckel Syndrome 4

SCKL4

Seckel Syndrome, Type 4

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Nijmegen Breakage Syndrome

Berlin Breakage Syndrome

NBS

Microcephaly, Normal Intelligence And Immunodeficiency

Ataxia-Telangiectasia Variant

Ataxia-Telangiectasia Variant V1

Seemanova Syndrome Ii

Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome

Seemanova Syndrome Type 2

At-V1

Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies

Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence

Immunodeficiency, Microcephaly, And Chromosomal Instability

Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome

Microcephaly Immunodeficiency Lymphoreticuloma

Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies

Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence

Seemanova Syndrome 2

Ataxia-Telangiectasia Variant 1

Seemanova Syndrome

At V1

Ataxia-Telangiectasia, Variant 1

Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome

V-At

Ataxia Telangiectasia Variant V1

Hereditary Ataxia

Sca

Spinocerebellar Ataxia

Ataxias Hereditary

Ataxias, Hereditary

Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism

Cerebellar Disease

Cerebellar Diseases

Cerebellar Dysfunction

Cerebellar Abnormality

Cerebellar Disorders

Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc

Aplastic Anemia

Aplastic Anemia, Susceptibility To

Anemia Aplastic

Idiopathic Aplastic Anemia

Secondary Aplastic Anemia

Idiopathic Bone Marrow Failure

Aplastic Anemia Idiopathic

AA

Anemia, Aplastic

Aplastic Anemia, Idiopathic

Erythroid Aplasia

Aa - [Aplastic Anaemia]

Haematopoietic Aplasia

Aleukia Haemorrhagica

Anaemia Due To Decreased Red Cell Production

Aplasia Bone Marrow

Aplastic Bone Marrow

Hypoplastic Anaemia Nos

Myeloid Bone Marrow Aplasia

Pancytopenia

Panhaematopenia

Hypoproliferative Anaemia

Medullary Hypoplasia

Red Blood Cells Hypoplastic Anaemia

Panmyelophthisis

Panhemocytopenia

Refractive Hypoproliferative Anaemia

Toxic Anaemia

Toxic Aplastic Anaemia

Aplastic Anaemia Due To Toxic Cause

Idiopathic Aplastic Anaemia Nos

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus TP53BP1 VGNC VGNC:36232
Mus musculus TP53BP1 MGD MGI:1351320
Rattus norvegicus TP53BP1 RGD RGD:1308039
Canis familiaris TP53BP1 VGNC VGNC:47720
Felis catus TP53BP1 VGNC VGNC:66461
Macaca mulatta TP53BP1 VGNC VGNC:78628