HEXIM1 - HEXIM P-TEFb complex subunit 1 Gene

Homo sapiens

Also known as CLP1; EDG1; HIS1; MAQ1

Gene ID: 10614 | Gene type: protein coding

About HEXIM1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,148,475-45,152,099 (from NCBI)

This gene has 1 transcript (splice variant), 116 orthologues and 1 paralogue.

Summary

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

HEXIM1 Products(1)

mRNA	Protein	Name
NM_006460.3	NP_006451.1	protein HEXIM1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 7SK snRNA binding	IDA IDA: Inferred from direct assay	12832472	GOA
enables P-TEFb complex binding	IDA IDA: Inferred from direct assay	18249148	GOA
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA IDA: Inferred from direct assay	14580347	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17724342	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12832472	GOA
enables protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	28431135	GOA
enables snRNA binding	IDA IDA: Inferred from direct assay	14580347	GOA
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	14580347	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	28712728	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18483487	GOA
involved in negative regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	14580347	GOA
involved in negative regulation of viral transcription	IMP IMP: Inferred from mutant phenotype	18249148	GOA
involved in positive regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	22948151	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of 7SK snRNP	IDA IDA: Inferred from direct assay	18249148	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12581153	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12581153	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HEXIM1 Protein Structure

HEXIM

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

protein HEXIM1

HMBA-inducible

HEXIM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	TAP	24981860
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Anti Bait CoIP	25470060
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Anti Bait CoIP	18483487
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Pull Down	18483487
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	28514442
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Pull Down	18483487
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	18281698
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	18483487
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	25470060
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Fluorescence Spectr	17724342
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	17724342
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Bait CoIP	18483487
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Bait CoIP	18281698
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	28514442
Intra	HEXIM1	O94992	HEXIM2	Homo sapiens	Q96MH2	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	HEXIM2	Homo sapiens	Q96MH2	Anti Tag CoIP	28514442
Intra	HEXIM1	O94992	HEXIM2	Homo sapiens	Q96MH2	Validated Y2H	32296183
Intra	HEXIM1	O94992	TERF2	Homo sapiens	Q15554	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163282	NB512	Inhibitor	/	Unkown
HY-RS06145	HEXIM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HEXIM1	VGNC	VGNC:62803
Macaca mulatta	HEXIM1	VGNC	VGNC:104615
Mus musculus	HEXIM1	MGD	MGI:2385923
Rattus norvegicus	HEXIM1	RGD	RGD:1559851
Bos taurus	HEXIM1	VGNC	VGNC:29826
Canis familiaris	HEXIM1	VGNC	VGNC:41670

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