CCNT1 - cyclin T1 Gene

Homo sapiens

Also known as CCNT; CYCT1; HIVE1

Gene ID: 904 | Gene type: protein coding

About CCNT1

Cytogenetic location: 12q13.11-q13.12 Genomic coordinates (GRCh38): 12:48,688,458-48,716,707 (from NCBI)

This gene has 6 transcripts (splice variants), 224 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 11.5), testis (RPKM 9.4) and 25 other tissues.

Summary

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

CCNT1 Products(5)

mRNA	Protein	Name
NM_001240.4	NP_001231.2	cyclin-T1 isoform a
NM_001277842.2	NP_001264771.1	cyclin-T1 isoform b
NM_001413198.1	NP_001400127.1	cyclin-T1 isoform c
NM_001413199.1	NP_001400128.1	cyclin-T1 isoform d
NM_001413200.1	NP_001400129.1	cyclin-T1 isoform e

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 7SK snRNA binding	IDA IDA: Inferred from direct assay	11713533	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	16109376	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	25116364	GOA
enables RNA polymerase binding	IPI IPI: Inferred from physical interaction	15563843	GOA
enables cyclin-dependent protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	29849146	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	29849146	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9499409	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation by host of viral transcription	IDA IDA: Inferred from direct assay	10866664	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15563843	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	9499409	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of P-TEFb complex	IDA IDA: Inferred from direct assay	18483487	GOA
part of cyclin/CDK positive transcription elongation factor complex	IDA IDA: Inferred from direct assay	9499409	GOA
part of cyclin/CDK positive transcription elongation factor complex	IPI IPI: Inferred from physical interaction	18566585	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	16109376	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	29849146	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12944466	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNT1 Protein Structure

Cyclin_N

0
200
400
600
726 a.a.

Protein Preferred Names

Protein Names

cyclin-T1

CDK9-associated C-type protein

CCNT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	X-Ray Diffraction	20535204
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Anti Tag CoIP	26659056
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	CoIP	9491887
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Pull Down	18483487
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Anti Bait CoIP	20562857
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Anti Bait CoIP	19387490
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Ion Exchange Chrom	20535204
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Anti Tag CoIP	19387490
Intra	CCNT1	O60563	CDK9	Homo sapiens	P50750	Anti Bait CoIP	18483487
Intra	CCNT1	O60563	HEXIM1	Homo sapiens	O94992	NMR	17724342
Intra	CCNT1	O60563	HEXIM1	Homo sapiens	O94992	Anti Tag CoIP	19387490
Intra	CCNT1	O60563	HEXIM1	Homo sapiens	O94992	Anti Bait CoIP	19387490
Intra	CCNT1	O60563	HEXIM1	Homo sapiens	O94992	Anti Bait CoIP	18483487
Intra	CCNT1	O60563	AFF4	Homo sapiens	Q9UHB7	Anti Tag CoIP	20153263
Cross	CCNT1	O60563	tat	Human immunodeficiency virus	P04608	Ion Exchange Chrom	20535204
Cross	CCNT1	O60563	tat	Human immunodeficiency virus	P04608	X-Ray Diffraction	20535204

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122720	SEC inhibitor KL-1	Activator	99.38%	Unkown
HY-123972	SEC inhibitor KL-2	Inhibitor	99.80%	Unkown
HY-RS02141	CCNT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CCNT1	VGNC	VGNC:70735
Bos taurus	CCNT1	VGNC	VGNC:26978
Mus musculus	CCNT1	MGD	MGI:1328363
Rattus norvegicus	CCNT1	RGD	RGD:1311151
Canis familiaris	CCNT1	VGNC	VGNC:38906
Others	CCNT1	NCBI

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