CDK9 - cyclin dependent kinase 9 Gene

Homo sapiens

Also known as TAK; C-2k; CTK1; CDC2L4; PITALRE

Gene ID: 1025 | Gene type: protein coding

About CDK9

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:127,786,034-127,790,792 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 26 paralogues. Ubiquitous expression in ovary (RPKM 32.0), spleen (RPKM 23.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]

CDK9 Products(1)

mRNA	Protein	Name
NM_001261.4	NP_001252.1	cyclin-dependent kinase 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 7SK snRNA binding	IDA IDA: Inferred from direct assay	11713533	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	16109376	GOA
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA IDA: Inferred from direct assay	9499409	GOA
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12037670	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	22959624	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9499409	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14701750	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	12037672	GOA
enables transcription elongation factor activity	IDA IDA: Inferred from direct assay	14580347	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	17956865	GOA
involved in negative regulation of protein localization to chromatin	IDA IDA: Inferred from direct assay	14701750	GOA
involved in nucleus localization	IDA IDA: Inferred from direct assay	12942536	GOA
involved in positive regulation by host of viral transcription	IDA IDA: Inferred from direct assay	10866664	GOA
involved in positive regulation of protein localization to chromatin	IDA IDA: Inferred from direct assay	29335245	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	29335245	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	9499409	GOA
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	16109376	GOA
involved in regulation of DNA repair	IDA IDA: Inferred from direct assay	20493174	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	20930849	GOA
involved in regulation of mRNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	19575011	GOA
NOT involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19575011	GOA
involved in regulation of muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	12037670	GOA
involved in replication fork processing	IDA IDA: Inferred from direct assay	20930849	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	28426094	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	14580347	GOA
involved in transcription elongation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	19844166	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of P-TEFb complex	IDA IDA: Inferred from direct assay	18483487	GOA
located in PML body	IDA IDA: Inferred from direct assay	18250157	GOA
part of cyclin/CDK positive transcription elongation factor complex	IDA IDA: Inferred from direct assay	9499409	GOA
part of cyclin/CDK positive transcription elongation factor complex	IPI IPI: Inferred from physical interaction	9499409	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	14701750	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9499409	GOA
part of transcription elongation factor complex	IDA IDA: Inferred from direct assay	22195968	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK9 Protein Structure

Pkinase

0
100
200
300
372 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 9

CDC2-related kinase	cell division cycle 2-like protein kinase 4
cell division protein kinase 9	serine/threonine protein kinase PITALRE
tat-associated kinase complex catalytic subunit

Related Diseases

Diseases

Alias

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Leukemia, Myeloid, Acute	Acute Myeloid Leukemia, Somatic
Leukemia, Acute Myeloid, Somatic	Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic
Acute Myeloblastic Leukaemia	Acute Myelogenous Leukaemia
Aml - Acute Myeloid Leukemia	Acute Myeloid Leukemia With Cebpa Somatic Mutations
Aml With Cebpa Somatic Mutations	Inherited Acute Myeloid Leukemia
Familial Aml	Inherited Aml
Pure Familial Aml	Pure Familial Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia	Therapy-Related Aml And Myelodysplastic Syndrome
Acute Myeloid Leukemia, Secondary	Acute Non-Lymphoblastic Leukemia
Acute Non-Lymphocytic Leukemia	Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia	Acute Myeloblastic Leukaemia With Multilineage Dysplasia
Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission	Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1	PCH1E
Norman Disease	Pch1
Pontocerebellar Hypoplasia With Anterior Horn Cell Disease	Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy
Pontocerebellar Hypoplasia Type 1e	Pontocerebellar Hypoplasia 1e
Doid:0112322	Doid:0112330

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Hypothyroidism, Congenital, Nongoitrous, 6

CHNG6	Congenital Nongoitrous Hypothyroidism 6
Hypothyroidism, Congenital, Non-Goitrous, 6	Hypothyroidism, Congenital, Nongoitrous, Type 6

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Charge Syndrome

Charge Association	Hall-Hittner Syndrome
Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies	Hhs
Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies	Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome
CHARGES

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.94%	Yes
HY-10492	Dinaciclib	Inhibitor	99.36%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes

Clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112088	AZD4573	Inhibitor	99.98%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-50940	AT7519	Inhibitor	99.76%	Phase 2
HY-101212	Fadraciclib	Inhibitor	99.78%	Phase 2
HY-13914	Roniciclib	Inhibitor	98.09%	Phase 2
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.11%	Phase 2
HY-103712B	Samuraciclib hydrochloride hydrate	Inhibitor	99.08%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.42%	Phase 2
HY-112272	Lerociclib	Inhibitor	98.35%	Phase 2
HY-16559A	Riviciclib	Inhibitor	/	Phase 2
HY-138293	SY-5609	Inhibitor	99.66%	Phase 1
HY-10008	SNS-032	Inhibitor	99.54%	Phase 1
HY-137478A	KB-0742 dihydrochloride	Inhibitor	99.24%	Phase 1
HY-10012	AZD-5438	Inhibitor	99.85%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.80%	Phase 1
HY-11001	PHA-793887	Inhibitor	99.25%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.70%	Phase 1
HY-12422	Voruciclib	Inhibitor	99.77%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.07%	Phase 1
HY-12422A	Voruciclib hydrochloride	Inhibitor	99.23%	Phase 1
HY-50940A	AT7519 TFA	Inhibitor	98.53%	Phase 1

Pre-clinical Phase

Bioactive Molecules (106)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103618	THZ531	Inhibitor	99.86%	Unkown
HY-103248	Toyocamycin	Inhibitor	99.90%	Unkown
HY-12214A	NVP-2	Inhibitor	99.60%	Unkown
HY-103019	(+)-Enitociclib	Inhibitor	99.66%	Unkown
HY-130665	TL12-186	Inhibitor	99.63%	Unkown
HY-101257	YKL-5-124	Inhibitor	98.79%	Unkown
HY-111388A	SEL120-34A monohydrochloride	Inhibitor	99.29%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.61%	Unkown
HY-11009	CGP60474	Inhibitor	99.23%	Unkown
HY-130709	PROTAC CDK2/9 Degrader-1	Inhibitor	99.85%	Unkown
HY-123954	BTX-A51	Inhibitor	98.58%	Unkown
HY-15878	LDC000067	Inhibitor	98.00%	Unkown
HY-12445	Asnuciclib	Inhibitor	99.76%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.80%	Unkown
HY-13461A	PHA-767491 hydrochloride	Inhibitor	98.06%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	98.95%	Unkown
HY-112626	CDK12-IN-2	Inhibitor	99.36%	Unkown
HY-103628	PROTAC CDK9 Degrader-1	Inhibitor	98.03%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-X0150	JSH-150	Inhibitor	98.36%	Unkown
HY-144117	GFB-12811	Inhibitor	98.00%	Unkown
HY-12293	LY2857785	Inhibitor	99.92%	Unkown
HY-117203A	CDK12-IN-E9	Inhibitor	99.97%	Unkown
HY-119940	MC180295	Inhibitor	98.89%	Unkown
HY-111388B	SEL120-34A hydrochloride	Inhibitor	99.98%	Unkown
HY-13231	CDK9-IN-1	Inhibitor	98.52%	Unkown
HY-16462	CDK9-IN-2	Inhibitor	99.37%	Unkown
HY-16559	Riviciclib hydrochloride		98.89%	Unkown
HY-143584	AZ5576	Inhibitor	99.88%	Unkown
HY-103019B	(-)-Enitociclib	Inhibitor	99.69%	Unkown
HY-101257B	YKL-5-124 TFA	Inhibitor	99.44%	Unkown
HY-13033	CDK-IN-2	Inhibitor	98.97%	Unkown
HY-123955	Casein Kinase inhibitor A86	Inhibitor	99.26%	Unkown
HY-18944	FIT-039	Inhibitor	99.56%	Unkown
HY-103646	CK7	Inhibitor	99.72%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.91%	Unkown
HY-12871	Atuveciclib Racemate	Inhibitor	98.48%	Unkown
HY-102039	CDK9-IN-8	Inhibitor	99.65%	Unkown
HY-126251	CDK9-IN-7	Inhibitor	98.05%	Unkown
HY-139980	CDK9-IN-13	Inhibitor	99.22%	Unkown
HY-153260	TP-1287	Inhibitor	95.10%	Unkown
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Unkown
HY-100429	CAN508	Inhibitor	99.59%	Unkown
HY-130852	CDK9-IN-11	Inhibitor	96.03%	Unkown
HY-100950	ABC1183	Inhibitor	99.19%	Unkown
HY-153556	GW297361	Inhibitor	98.13%	Unkown
HY-124639	CDK9 inhibitor HH1	Inhibitor	97.97%	Unkown
HY-X0009	JSH-009	Inhibitor	/	Unkown
HY-111427	CDK8/19-IN-1	Inhibitor	98.03%	Unkown
HY-139328	CDK12-IN-5	Inhibitor	99.01%	Unkown
HY-162037	CDDD11-8	Inhibitor	99.62%	Unkown
HY-115714	CDK9-IN-12	Inhibitor	99.65%	Unkown
HY-130850	CDK9-IN-10	Inhibitor	98.00%	Unkown
HY-12843	Bohemine	Inhibitor	98.93%	Unkown
HY-143585	CDK9-IN-14	Inhibitor	99.91%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-111388	SEL120-34A	Inhibitor	/	Unkown
HY-14372	BS-194	Inhibitor	99.36%	Unkown
HY-X0009A	JSH-009 dimaleate	Inhibitor	/	Unkown
HY-139329	CDK12-IN-6	Inhibitor	98.09%	Unkown
HY-13461	PHA-767491	Inhibitor	99.85%	Unkown
HY-151436	ZLMT-12	Inhibitor	/	Unkown
HY-130981	FN-1501-propionic acid		/	Unkown
HY-110368	BS-181 dihydrochloride	Inhibitor	/	Unkown
HY-131063	CDK6/9-IN-1	Inhibitor	/	Unkown
HY-130001	CDK9-IN-9	Inhibitor	/	Unkown
HY-103712	Samuraciclib	Inhibitor	/	Unkown
HY-157980	CDK9-IN-32	Inhibitor	/	Unkown
HY-168518	PROTAC CDK9 degrader-9	Degrader	/	Unkown
HY-136841	SLM6	Inhibitor	/	Unkown
HY-149495	CP-07	Degrader	/	Unkown
HY-169244	CDK-TCIP1	Inhibitor	/	Unkown
HY-155153	CDK9-IN-24	Inhibitor	/	Unkown
HY-111356	IIIM-290	Inhibitor	/	Unkown
HY-137478	KB-0742	Inhibitor	/	Unkown
HY-149870	PROTAC CDK9 degrader-8	Inhibitor	/	Unkown
HY-151898	CDK4/6-IN-14	Inhibitor	/	Unkown
HY-112811	PROTAC CDK9 degrader-2	Inhibitor	/	Unkown
HY-153426	CDK9-IN-23	Inhibitor	/	Unkown
HY-155787	SHR5428	Inhibitor	/	Unkown
HY-151984	CDK9-IN-22	Inhibitor	/	Unkown
HY-161768	VCC972839:01	Inhibitor	/	Unkown
HY-161379	CLZX-205	Inhibitor	/	Unkown
HY-139327	CDK12-IN-4	Inhibitor	/	Unkown
HY-150573	CDK2-IN-12	Inhibitor	/	Unkown
HY-156795	PROTAC CDK9/CycT1 Degrader-2	Inhibitor	/	Unkown
HY-145408	CDK7/9-IN-1	Inhibitor	/	Unkown
HY-162619	CDK9-IN-33	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-149963	PROTAC CDK9 degrader-6	Inhibitor	/	Unkown
HY-147771	ZLWT-37	Inhibitor	/	Unkown
HY-156083	CDK9-IN-28	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-149962	PROTAC CDK9 degrader-5	Inhibitor	/	Unkown
HY-161595	CDK5-IN-4	Inhibitor	/	Unkown
HY-150641	CDK-IN-9	Inhibitor	/	Unkown
HY-123034	CDKI-83	Inhibitor	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-150562	CDK9-IN-19	Inhibitor	/	Unkown
HY-162706	BSJ-5-63	Degrader	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-123826	CCT68127	Inhibitor	/	Unkown
HY-112403	(S)-Roscovitine	Inhibitor	/	Unkown
HY-119120	JTK-101	Inhibitor	/	Unkown
HY-112450	Olomoucine II	Inhibitor	/	Unkown
HY-164619	CDK9-IN-34	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDK9	MGD	MGI:1328368
Macaca mulatta	CDK9	VGNC	VGNC:104886
Canis familiaris	CDK9	VGNC	VGNC:39062
Felis catus	CDK9	VGNC	VGNC:102911
Bos taurus	CDK9	VGNC	VGNC:27136
Rattus norvegicus	CDK9	RGD	RGD:1359638
Others	CDK9	NCBI

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