CCT8 - chaperonin containing TCP1 subunit 8 Gene

Homo sapiens

Also known as Cctq; PRED71; D21S246; C21orf112

Gene ID: 10694 | Gene type: protein coding

About CCT8

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:29,056,326-29,073,648 (from NCBI)

This gene has 12 transcripts (splice variants), 212 orthologues and 13 paralogues. Ubiquitous expression in adrenal (RPKM 57.9), lymph node (RPKM 57.3) and 25 other tissues.

Summary

This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

CCT8 Products(4)

mRNA	Protein	Name
NM_001282907.2	NP_001269836.1	T-complex protein 1 subunit theta isoform 2
NM_001282908.2	NP_001269837.1	T-complex protein 1 subunit theta isoform 3
NM_001282909.2	NP_001269838.1	T-complex protein 1 subunit theta isoform 4
NM_006585.4	NP_006576.2	T-complex protein 1 subunit theta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14532270	GOA
enables protein folding chaperone	IDA IDA: Inferred from direct assay	25467444	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone mediated protein folding independent of cofactor	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	22133715	GOA
acts upstream of positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	30955883	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	25467444	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	20080638	GOA
part of chaperonin-containing T-complex	IDA IDA: Inferred from direct assay	23011926	GOA
part of chaperonin-containing T-complex	IPI IPI: Inferred from physical interaction	22133715	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA
located in microtubule	IDA IDA: Inferred from direct assay	21525035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCT8 Protein Structure

Cpn60_TCP1

0
100
200
300
400
500
548 a.a.

Protein Preferred Names

Protein Names

T-complex protein 1 subunit theta

CCT-theta

CCT8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CCT8	P50990	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	CCT8	P50990	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	CCT8	P50990	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	CCT8	P50990	CDHR3	Homo sapiens	Q6ZTQ4	Y2H Array	32814053
Intra	CCT8	P50990	CDHR3	Homo sapiens	Q6ZTQ4	Validated Y2H	32814053
Intra	CCT8	P50990	CDHR3	Homo sapiens	Q6ZTQ4	Y2H Pooling	32814053
Intra	CCT8	P50990	SNX12	Homo sapiens	Q9UMY4	Validated Y2H	32814053
Intra	CCT8	P50990	SNX12	Homo sapiens	Q9UMY4	Y2H Array	32814053
Intra	CCT8	P50990	SNX12	Homo sapiens	Q9UMY4	Y2H Pooling	32814053
Intra	CCT8	P50990	TUBA1B	Homo sapiens	P68363-2	Validated Y2H	32814053
Intra	CCT8	P50990	TUBA1B	Homo sapiens	P68363-2	Y2H Array	32814053
Intra	CCT8	P50990	TUBA1B	Homo sapiens	P68363-2	Y2H Pooling	32814053
Intra	CCT8	P50990	TCP1	Homo sapiens	P17987	Anti Tag CoIP	35271311
Intra	CCT8	P50990	CCT6A	Homo sapiens	P40227	Anti Tag CoIP	35271311
Intra	CCT8	P50990	CCT6A	Homo sapiens	P40227	Y2H Array	32814053
Intra	CCT8	P50990	CCT6A	Homo sapiens	P40227	Validated Y2H	32814053
Intra	CCT8	P50990	CCT6A	Homo sapiens	P40227	Y2H Pooling	32814053
Intra	CCT8	P50990	BRME1	Homo sapiens	Q0VDD7	Validated Y2H	32814053
Intra	CCT8	P50990	BRME1	Homo sapiens	Q0VDD7	Y2H Array	32814053
Intra	CCT8	P50990	BRME1	Homo sapiens	Q0VDD7	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Otomycosis

Singapore Ear

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02185	CCT8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CCT8	VGNC	VGNC:70749
Felis catus	CCT8	VGNC	VGNC:60582
Mus musculus	CCT8	MGD	MGI:107183
Canis familiaris	CCT8	VGNC	VGNC:38927
Rattus norvegicus	CCT8	RGD	RGD:1305452

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