CCT6A - chaperonin containing TCP1 subunit 6A Gene

Homo sapiens

Also known as CCT6; Cctz; HTR3; TCPZ; TCP20; MoDP-2; TTCP20; CCT-zeta; CCT-zeta-1; TCP-1-zeta

Gene ID: 908 | Gene type: protein coding

About CCT6A

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:56,051,765-56,063,989 (from NCBI)

This gene has 9 transcripts (splice variants), 122 orthologues and 13 paralogues. Ubiquitous expression in appendix (RPKM 44.1), lymph node (RPKM 38.8) and 25 other tissues.

Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

CCT6A Products(2)

mRNA	Protein	Name
NM_001009186.2	NP_001009186.1	T-complex protein 1 subunit zeta isoform b
NM_001762.4	NP_001753.1	T-complex protein 1 subunit zeta isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables WD40-repeat domain binding	IPI IPI: Inferred from physical interaction	25467444	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14532270	GOA
enables protein folding chaperone	IDA IDA: Inferred from direct assay	25467444	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone mediated protein folding independent of cofactor	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	22133715	GOA
acts upstream of positive regulation of establishment of protein localization to telomere	IMP IMP: Inferred from mutant phenotype	25467444	GOA
acts upstream of positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	30955883	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	25467444	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of chaperonin-containing T-complex	IDA IDA: Inferred from direct assay	23011926	GOA
part of chaperonin-containing T-complex	IPI IPI: Inferred from physical interaction	22133715	GOA
located in microtubule	IDA IDA: Inferred from direct assay	21525035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCT6A Protein Structure

Cpn60_TCP1

0
100
200
300
400
500
531 a.a.

Protein Preferred Names

Protein Names

T-complex protein 1 subunit zeta

T-complex protein 1, zeta subunit

Related Diseases

Diseases

Alias

Morphine Dependence

Axillary Adenitis

Axillary Lymphadenitis

Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 4	SRTD4
Atd4	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02183	CCT6A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CCT6A	VGNC	VGNC:103797
Bos taurus	CCT6A	VGNC	VGNC:97250
Rattus norvegicus	CCT6A	RGD	RGD:1304763
Felis catus	CCT6A	VGNC	VGNC:80556
Canis familiaris	CCT6A	VGNC	VGNC:38926
Mus musculus	CCT6A	MGD	MGI:107943

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