NEK6 - NIMA related kinase 6 Gene

Homo sapiens

Also known as SID6-1512

Gene ID: 10783 | Gene type: protein coding

About NEK6

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,257,606-124,353,307 (from NCBI)

This gene has 15 transcripts (splice variants), 180 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 13.1), appendix (RPKM 13.0) and 25 other tissues.

Summary

The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to Apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

NEK6 Products(7)

mRNA	Protein	Name
NM_001145001.3	NP_001138473.1	serine/threonine-protein kinase Nek6 isoform 1
NM_001166167.2	NP_001159639.1	serine/threonine-protein kinase Nek6 isoform 3
NM_001166168.2	NP_001159640.1	serine/threonine-protein kinase Nek6 isoform 2
NM_001166169.2	NP_001159641.1	serine/threonine-protein kinase Nek6 isoform 4
NM_001166170.2	NP_001159642.1	serine/threonine-protein kinase Nek6 isoform 2
NM_001166171.2	NP_001159643.1	serine/threonine-protein kinase Nek6 isoform 1
NM_014397.6	NP_055212.2	serine/threonine-protein kinase Nek6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	14563848	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20873783	GOA
enables kinesin binding	IPI IPI: Inferred from physical interaction	19001501	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	14563848	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16476580	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19001501	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11516946	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	20873783	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	20873783	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome segregation	IDA IDA: Inferred from direct assay	14563848	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19001501	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	14563848	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12840024	GOA
involved in regulation of mitotic metaphase/anaphase transition	IDA IDA: Inferred from direct assay	14563848	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12054534	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12054534	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK6 Protein Structure

Pkinase

0
100
200
313 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase Nek6

NIMA (never in mitosis gene a)-related kinase 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122639	ZINC05007751		98.47%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NEK6	VGNC	VGNC:75311
Bos taurus	NEK6	VGNC	VGNC:31997
Felis catus	NEK6	VGNC	VGNC:68459
Canis familiaris	NEK6	VGNC	VGNC:43733
Mus musculus	NEK6	MGD	MGI:1891638
Rattus norvegicus	NEK6	RGD	RGD:727779
Others	NEK6	NCBI

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