2. Gene
  3. PPP1R13L - protein phosphatase 1 regulatory subunit 13 like Gene

PPP1R13L - protein phosphatase 1 regulatory subunit 13 like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RAI; RAI4; IASPP; NKIP1

Gene ID: 10848 | Gene type: protein coding

About PPP1R13L

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,379,638-45,406,361 (from NCBI)

This gene has 9 transcripts (splice variants), 174 orthologues and is associated with 1 phenotype. Broad expression in skin (RPKM 27.0), placenta (RPKM 6.4) and 14 other tissues.

Summary

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

PPP1R13L Products(2)

mRNA Protein Name
NM_001142502.2 NP_001135974.1 relA-associated inhibitor
NM_006663.4 NP_006654.2 relA-associated inhibitor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18275817 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17906639 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
28069640 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R13L Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (633 - 720)

SH3_9

SH3_9: Variant SH3 domain (765 - 814)

  • 0
  • 200
  • 400
  • 600
  • 828 a.a.
Protein Preferred Names Protein Names

relA-associated inhibitor

NFkB interacting protein 1

PPP1R13L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPP1R13L Q8WUF5 RAN Homo sapiens P62826
Pull Down
24855949
Intra
PPP1R13L Q8WUF5 RAN Homo sapiens P62826
SPR
24855949
Intra
PPP1R13L Q8WUF5 PPP1CB Homo sapiens P62140
Anti Tag CoIP
21998301
Intra
PPP1R13L Q8WUF5 PPP1CB Homo sapiens P62140
Anti Tag CoIP
33961781
Intra
PPP1R13L Q8WUF5 PPP1CA Homo sapiens P62136
Anti Bait CoIP
21998301
Intra
PPP1R13L Q8WUF5 PPP1CA Homo sapiens P62136
Anti Tag CoIP
21998301
Intra
PPP1R13L Q8WUF5 TP53 Homo sapiens P04637
Anti Bait CoIP
17906639
Intra
PPP1R13L Q8WUF5 TP53 Homo sapiens P04637
Anti Bait CoIP
23623661
Intra
PPP1R13L Q8WUF5 TP53 Homo sapiens P04637
Anti Bait CoIP
21513714
Intra
PPP1R13L Q8WUF5 TP53 Homo sapiens P04637
Solid Phase Assay
18275817
Intra
PPP1R13L Q8WUF5 TP53 Homo sapiens P04637
IF
23623661
Intra
PPP1R13L Q8WUF5 EP300 Homo sapiens Q09472
Anti Bait CoIP
21513714
Cross
PPP1R13L Q8WUF5 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Y2H Prey Pooling
18985028
Cross
PPP1R13L Q8WUF5 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Pull Down
18985028
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Multiple Congenital Anomalies/Dysmorphic Syndrome
Noonan Syndrome With Multiple Lentigines

Leopard Syndrome

Multiple Lentigines Syndrome

Moynahan Syndrome

Cardiomyopathic Lentiginosis

Progressive Cardiomyopathic Lentiginosis

Cardio-Cutaneous Syndrome

Lentiginosis Profusa

Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

Generalized Lentiginosis

Gorlin Syndrome Ii

Lentiginosis Profusa Syndrome

Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

Diffuse Lentiginosis

Nsml

Familial Multiple Lentigines Syndrome

Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

Progressive Cardiomyopathic Lentiginosis Syndrome

Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Spinal Chordoma

Chordoma Of Spine

Vertebral Chordoma
Smith-Magenis Syndrome

SMS

Chromosome 17p11.2 Deletion Syndrome

17p11.2 Microdeletion Syndrome

17p11.2 Monosomy

Chromosome 17p Deletion Syndrome

Del(17)

P11.2

17p- Syndrome

Deletion 17p Syndrome

Partial Monosomy 17p
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10982 PPP1R13L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPP1R13L RGD RGD:1593681
Bos taurus PPP1R13L VGNC VGNC:33225
Mus musculus PPP1R13L MGD MGI:3525053
Canis familiaris PPP1R13L VGNC VGNC:44882