2. Gene
  3. ZWINT - ZW10 interacting kinetochore protein Gene

ZWINT - ZW10 interacting kinetochore protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SIP30; ZWINT1; KNTC2AP; HZwint-1

Gene ID: 11130 | Gene type: protein coding

About ZWINT

Cytogenetic location: 10q21.1 Genomic coordinates (GRCh38): 10:56,357,227-56,361,273 (from NCBI)

This gene has 9 transcripts (splice variants) and 108 orthologues. Broad expression in bone marrow (RPKM 17.2), testis (RPKM 16.4) and 21 other tissues.

Summary

This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ZWINT Products(3)

mRNA Protein Name
NM_001005413.1 NP_001005413.1 ZW10 interactor isoform b
NM_007057.4 NP_008988.2 ZW10 interactor isoform a
NM_032997.3 NP_127490.1 ZW10 interactor isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15485811 GOA
Biological Process GO Annotation Evidence Reference Source
involved in establishment of localization in cell IDA
IDA: Inferred from direct assay
15485811 GOA
involved in mitotic sister chromatid segregation IDA
IDA: Inferred from direct assay
15485811 GOA
involved in mitotic spindle assembly checkpoint signaling IDA
IDA: Inferred from direct assay
15485811 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Knl1/Spc105 complex IDA
IDA: Inferred from direct assay
27881301 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11682612 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
11682612 GOA
part of outer kinetochore IDA
IDA: Inferred from direct assay
24530301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZWINT Protein Structure

Zwint

Zwint: ZW10 interactor (29 - 277)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

ZW10 interactor

SNAP25 interacting protein of 30 kDa

Recombinant ZWINT Proteins

Cat. No. Product Name Accession Purity
HY-P71000 ZWINT/ZW10 interactor Protein, Human (His) AAI10400.1 (M1-P277) ≥95%
HY-P71527 ZWINT/ZW10 interactor Protein, Human (GST) O95229-1 (M1-P277) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16210 ZWINT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZWINT VGNC VGNC:78916
Canis familiaris ZWINT VGNC VGNC:48866
Mus musculus ZWINT MGD MGI:1289227
Felis catus ZWINT VGNC VGNC:67390
Rattus norvegicus ZWINT RGD RGD:628671
Others ZWINT NCBI