2. Gene
  3. ZWINT - ZW10 interacting kinetochore protein Gene

ZWINT - ZW10 interacting kinetochore protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SIP30; ZWINT1; KNTC2AP; HZwint-1

Gene ID: 11130 | Gene type: protein coding

About ZWINT

Cytogenetic location: 10q21.1 Genomic coordinates (GRCh38): 10:56,357,227-56,361,273 (from NCBI)

This gene has 9 transcripts (splice variants) and 108 orthologues. Broad expression in bone marrow (RPKM 17.2), testis (RPKM 16.4) and 21 other tissues.

Summary

This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ZWINT Products(3)

mRNA Protein Name
NM_001005413.1 NP_001005413.1 ZW10 interactor isoform b
NM_007057.4 NP_008988.2 ZW10 interactor isoform a
NM_032997.3 NP_127490.1 ZW10 interactor isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15485811 GOA
Biological Process GO Annotation Evidence Reference Source
involved in establishment of localization in cell IDA
IDA: Inferred from direct assay
15485811 GOA
involved in mitotic sister chromatid segregation IDA
IDA: Inferred from direct assay
15485811 GOA
involved in mitotic spindle assembly checkpoint signaling IDA
IDA: Inferred from direct assay
15485811 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Knl1/Spc105 complex IDA
IDA: Inferred from direct assay
27881301 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11682612 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
11682612 GOA
part of outer kinetochore IDA
IDA: Inferred from direct assay
24530301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZWINT Protein Structure

Zwint

Zwint: ZW10 interactor (29 - 277)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

ZW10 interactor

SNAP25 interacting protein of 30 kDa

ZWINT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZWINT O95229 ZW10 Homo sapiens O43264
Anti Tag CoIP
15824131
Intra
ZWINT O95229 ZW10 Homo sapiens O43264
IF
16732327
Intra
ZWINT O95229 ZW10 Homo sapiens O43264
Pull Down
16732327
Intra
ZWINT O95229 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra
ZWINT O95229 BFSP1 Homo sapiens Q12934-2
Validated Y2H
32296183
Intra
ZWINT O95229 KRT75 Homo sapiens O95678
Validated Y2H
32296183
Intra
ZWINT O95229 TSG101 Homo sapiens Q99816
Validated Y2H
32296183
Intra
ZWINT O95229 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra
ZWINT O95229 NDC80 Homo sapiens O14777
Anti Tag CoIP
26496610
Intra
ZWINT O95229 NDC80 Homo sapiens O14777
Anti Tag CoIP
28514442
Intra
ZWINT O95229 NDC80 Homo sapiens O14777
MAPPIT
25416956
Intra
ZWINT O95229 NDC80 Homo sapiens O14777
Pull Down
16732327
Intra
ZWINT O95229 NDC80 Homo sapiens O14777
IF
16732327
Intra
ZWINT O95229 NDC80 Homo sapiens O14777
TAP
20360068
Intra
ZWINT O95229 NDC80 Homo sapiens O14777
TAP
15824131
Intra
ZWINT O95229 NDC80 Homo sapiens O14777
Anti Tag CoIP
33961781
Intra
ZWINT O95229 NDC80 Homo sapiens O14777
Anti Bait CoIP
16732327
Intra
ZWINT O95229 NUP54 Homo sapiens Q7Z3B4
Validated Y2H
32296183
Intra
ZWINT O95229 BECN1 Homo sapiens Q14457
IF
23478334
Intra
ZWINT O95229 BECN1 Homo sapiens Q14457
Y2H
22081109
Intra
ZWINT O95229 BECN1 Homo sapiens Q14457
Pull Down
23478334
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ZWINT Proteins

Cat. No. Product Name Accession Purity
HY-P71000 ZWINT/ZW10 interactor Protein, Human (His) AAI10400.1 (M1-P277) ≥95%
HY-P71527 ZWINT/ZW10 interactor Protein, Human (GST) O95229-1 (M1-P277) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16210 ZWINT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZWINT VGNC VGNC:78916
Canis familiaris ZWINT VGNC VGNC:48866
Mus musculus ZWINT MGD MGI:1289227
Felis catus ZWINT VGNC VGNC:67390
Rattus norvegicus ZWINT RGD RGD:628671
Others ZWINT NCBI