2. Gene
  3. NUP54 - nucleoporin 54 Gene

NUP54 - nucleoporin 54 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 53371 | Gene type: protein coding

About NUP54

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:76,114,664-76,148,397 (from NCBI)

This gene has 29 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in bone marrow (RPKM 12.3), testis (RPKM 11.6) and 25 other tissues.

Summary

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]

NUP54 Products(2)

mRNA Protein Name
NM_001278603.2 NP_001265532.1 nucleoporin p54 isoform 2
NM_017426.4 NP_059122.2 nucleoporin p54 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
24315095 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP54 Protein Structure

Nup54

Nup54: Nucleoporin complex subunit 54 (299 - 439)

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  • 507 a.a.
Protein Preferred Names Protein Names

nucleoporin p54

54 kDa nucleoporin

NUP54 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra NUP54 Q7Z3B4 ZWINT Homo sapiens O95229
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 ZWINT Homo sapiens O95229
Y2H Array
32296183
Intra NUP54 Q7Z3B4 CENPH Homo sapiens Q9H3R5
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 CENPH Homo sapiens Q9H3R5
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 TEKT1 Homo sapiens Q969V4
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 TEKT1 Homo sapiens Q969V4
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 TEKT1 Homo sapiens Q969V4
Y2H Array
32296183
Intra NUP54 Q7Z3B4 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra NUP54 Q7Z3B4 EXOC1 Homo sapiens Q9NV70
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 EXOC1 Homo sapiens Q9NV70
Anti Tag CoIP
33961781
Intra NUP54 Q7Z3B4 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra NUP54 Q7Z3B4 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 AP2B1 Homo sapiens P63010-2
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 AP2B1 Homo sapiens P63010-2
Y2H Array
32296183
Intra NUP54 Q7Z3B4 AP1B1 Homo sapiens Q10567-3
Y2H Array
32296183
Intra NUP54 Q7Z3B4 AP1B1 Homo sapiens Q10567-3
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 TEX12 Homo sapiens Q9BXU0
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 TEX12 Homo sapiens Q9BXU0
Y2H Array
32296183
Intra NUP54 Q7Z3B4 TEX12 Homo sapiens Q9BXU0
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 DCTN3 Homo sapiens O75935-2
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 DCTN3 Homo sapiens O75935-2
Y2H Array
32296183
Intra NUP54 Q7Z3B4 SOHLH1 Homo sapiens Q5JUK2
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 SOHLH1 Homo sapiens Q5JUK2
Y2H Array
32296183
Intra NUP54 Q7Z3B4 EURL Homo sapiens Q9NYK6-3
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 EURL Homo sapiens Q9NYK6-3
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 EURL Homo sapiens Q9NYK6-3
Y2H Array
32296183
Cross NUP54 Q7Z3B4 P0DTD1-PRO_0000449627 SARS-CoV-2 P0DTD1-PRO_0000449627
Y2H Array
36217030
Intra NUP54 Q7Z3B4 TACC3 Homo sapiens Q9Y6A5
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 TACC3 Homo sapiens Q9Y6A5
Y2H Array
32296183
Intra NUP54 Q7Z3B4 TACC3 Homo sapiens Q9Y6A5
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 HAUS8 Homo sapiens Q9BT25
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 HAUS8 Homo sapiens Q9BT25
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 HAUS8 Homo sapiens Q9BT25
Y2H Array
32296183
Intra NUP54 Q7Z3B4 PKNOX2 Homo sapiens Q96KN3
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 PKNOX2 Homo sapiens Q96KN3
Y2H Array
32296183
Intra NUP54 Q7Z3B4 PKNOX2 Homo sapiens Q96KN3
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 NUP58 Homo sapiens Q9BVL2
Anti Tag CoIP
33961781
Intra NUP54 Q7Z3B4 NUP58 Homo sapiens Q9BVL2
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 NUP58 Homo sapiens Q9BVL2
Crosslink
30021884
Intra NUP54 Q7Z3B4 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra NUP54 Q7Z3B4 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 SMYD3 Homo sapiens Q9H7B4
Y2H Array
32296183
Intra NUP54 Q7Z3B4 SMYD3 Homo sapiens Q9H7B4
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 SMYD3 Homo sapiens Q9H7B4
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 NUP62 Homo sapiens P37198
Validated Y2H
25416956
Intra NUP54 Q7Z3B4 NUP62 Homo sapiens P37198
Y2H Array
25416956
Intra NUP54 Q7Z3B4 NUP62 Homo sapiens P37198
Anti Tag CoIP
33961781
Intra NUP54 Q7Z3B4 NUP62 Homo sapiens P37198
Y2H Array
27194810
Intra NUP54 Q7Z3B4 NUP62 Homo sapiens P37198
Y2H Array
32296183
Intra NUP54 Q7Z3B4 NUP62 Homo sapiens P37198
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 TPM3 Homo sapiens P06753
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 TPM3 Homo sapiens P06753
Y2H Array
32296183
Intra NUP54 Q7Z3B4 CDC23 Homo sapiens Q9UJX2
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra NUP54 Q7Z3B4 EIF3F Homo sapiens O00303
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 EIF3F Homo sapiens O00303
Y2H Array
32296183
Intra NUP54 Q7Z3B4 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra NUP54 Q7Z3B4 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 HGS Homo sapiens O14964
Y2H Array
25416956
Intra NUP54 Q7Z3B4 HGS Homo sapiens O14964
Y2H Prey Pooling
25416956
Intra NUP54 Q7Z3B4 HGS Homo sapiens O14964
Validated Y2H
25416956
Intra NUP54 Q7Z3B4 TCHP Homo sapiens Q9BT92
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 EXOC8 Homo sapiens Q8IYI6
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 IFT20 Homo sapiens Q8IY31
Validated Y2H
25416956
Intra NUP54 Q7Z3B4 HOMER1 Homo sapiens Q86YM7
Anti Tag CoIP
33961781
Intra NUP54 Q7Z3B4 HOMER1 Homo sapiens Q86YM7
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 HOMER1 Homo sapiens Q86YM7
Y2H Array
32296183
Intra NUP54 Q7Z3B4 HOMER1 Homo sapiens Q86YM7
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 SERTAD3 Homo sapiens Q9UJW9
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 SERTAD3 Homo sapiens Q9UJW9
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 SERTAD3 Homo sapiens Q9UJW9
Y2H Array
32296183
Intra NUP54 Q7Z3B4 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 IFT20 Homo sapiens Q8IY31-3
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 IFT20 Homo sapiens Q8IY31-3
Y2H Array
32296183
Intra NUP54 Q7Z3B4 IFT20 Homo sapiens Q8IY31-3
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Intra NUP54 Q7Z3B4 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Intra NUP54 Q7Z3B4 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Cross NUP54 Q7Z3B4 PA Influenza A virus Q67020
Pull Down
21994455
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09696 NUP54 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NUP54 VGNC VGNC:78542
Canis familiaris NUP54 VGNC VGNC:44057
Rattus norvegicus NUP54 RGD RGD:619926
Mus musculus NUP54 MGD MGI:1920460
Macaca mulatta NUP54 VGNC VGNC:75420