KRT71 - keratin 71 Gene

Homo sapiens

Also known as HYPT13; K6IRS1; KRT6IRS; KRT6IRS1

Gene ID: 112802 | Gene type: protein coding

About KRT71

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,543,909-52,553,145 (from NCBI)

This gene has 1 transcript (splice variant), 79 orthologues, 68 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

KRT71 Products(1)

mRNA	Protein	Name
NM_033448.3	NP_258259.1	keratin, type II cytoskeletal 71

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	22592156	GOA
involved in intermediate filament organization	IMP IMP: Inferred from mutant phenotype	22592156	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in keratin filament	IDA IDA: Inferred from direct assay	22592156	GOA
located in keratin filament	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT71 Protein Structure

Filament

0
100
200
300
400
523 a.a.

Protein Preferred Names

Protein Names

keratin, type II cytoskeletal 71

CK-71

KRT71 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KRT71	Q3SY84	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
Intra	KRT71	Q3SY84	KRT13	Homo sapiens	A1A4E9	Validated Y2H	25416956
Intra	KRT71	Q3SY84	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	KRT71	Q3SY84	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	KRT71	Q3SY84	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	25416956
Intra	KRT71	Q3SY84	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT71	Q3SY84	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	KRT71	Q3SY84	KRT28	Homo sapiens	Q7Z3Y7	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT28	Homo sapiens	Q7Z3Y7	Validated Y2H	32296183
Intra	KRT71	Q3SY84	KRT28	Homo sapiens	Q7Z3Y7	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT26	Homo sapiens	Q7Z3Y9	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT26	Homo sapiens	Q7Z3Y9	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT26	Homo sapiens	Q7Z3Y9	Validated Y2H	32296183
Intra	KRT71	Q3SY84	KRT24	Homo sapiens	Q2M2I5	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT24	Homo sapiens	Q2M2I5	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT18	Homo sapiens	P05783	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT18	Homo sapiens	P05783	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	KRT71	Q3SY84	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KRT71	Q3SY84	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
Intra	KRT71	Q3SY84	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	32296183
Intra	KRT71	Q3SY84	WASHC3	Homo sapiens	Q9Y3C0	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KRT71	Q3SY84	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	KRT71	Q3SY84	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT71	Q3SY84	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	KRT71	Q3SY84	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypotrichosis 13

HYPT13	Hypotrichosis With Woolly Hair
Hypotrichosis, Type 13

Familial Woolly Hair Syndrome

Wooly Hair	Familial Wooly Hair Syndrome
Hereditary Woolly Hair Syndrome	Hereditary Wooly Hair Syndrome
Woolly Hair	Syndrome With Woolly Hair
Wooly Hair Syndrome

Hypotrichosis

Woolly Hair, Autosomal Dominant

Autosomal Dominant Woolly Hair	ADWH
Woolly Hair Autosomal Dominant

T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy

Winged Helix Deficiency	Alymphoid Cystic Thymic Dysgenesis
Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy Syndrome	Pignata Guarino Syndrome
TIDAND	T-Cell Immunodeficiency, Congenital Alopecia And Nail Dystrophy
Congenital Alopecia And Nail Dystrophy Associated With Severe Functional T-Cell Immunodeficiency	Severe Combined Immunodeficiency Due To Foxn1 Deficiency
Foxn1 Deficiency	Nude/Scid
Nude/Severe Combined Immunodeficiency	Scid Due To Foxn1 Deficiency
Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy

Hypotrichosis 3

HYPT3	Hypotrichosis Simplex Of The Scalp 2
Htss2	Hypotrichosis, Type 3

Nail Disorder, Nonsyndromic Congenital, 4

Anonychia Congenita	Anonychia
Hyponychia Congenita	NDNC4
Anonychia/Hyponychia Congenita	Nonsyndromic Congenital Nail Disorder 4
Isolated Congenital Anonychia	Anonychia Congenita Totalis
Anonychia Totalis	Autosomal Recessive Nonsyndromic Congenital Nail Disorder-4
Congenital Anonychia	Nonsyndromic Congenital Nail Disorder, 4
Absent Nails	Aplastic Nails
Congenital Absence Of Nails	Isolated Anonychia
Nail Disorder, Non-Syndromic Congenital, 4	Nail Disorder, Nonsyndromic, Congenital, Type 4

Ectodermal Dysplasia 4, Hair/Nail Type

Pure Hair And Nail Ectodermal Dysplasia	ECTD4
Ectodermal Dysplasia, Pure Hair-Nail Type	Ectodermal Dysplasia, 'Pure' Hair/Nail Type
Hned	Hair-Nail Ectodermal Dysplasia
Phned	Ectodermal Dysplasia Pure Hair-Nail Type
Ectodermal Dysplasia, 'Pure' Hair-Nail Type	Dysplasia, Ectodermal, Type 4, Hair/Nail

Hypotrichosis 6

HYPT6	Lah1
Hypotrichosis, Localized, Autosomal Recessive	Monilethrix-Like Hypotrichosis
Hypotrichosis, Localized, Autosomal Recessive 1	Lah
Htl	Autosomal Recessive Localized Hypotrichosis
Hypotrichosis Localized Autosomal Recessive	Hypotrichosis Localized Autosomal Recessive 1
Hypotrichosis, Type 6

Nonsyndromic Congenital Nail Disorder

Nail Disorder, Nonsyndromic Congenital

Mucinoses

Hypotrichosis 4

HYPT4	Marie Unna Hereditary Hypotrichosis 1
Muhh1	Hypotrichosis, Marie Unna Type, 1
Hypotrichosis Marie Unna 1	Marie Unna Hereditary Hypotrichosis Type 1
Hypotrichosis, Hereditary, Marie Unna Type, 1	Hypotrichosis, Type 4

Monilethrix

Beaded Hair	MNLIX
Nodose Hair	Moniliform Hair Syndrome

Waardenburg Syndrome, Type 4c

Waardenburg Syndrome Type 4c	WS4C
Waardenburg Syndrome Type Ivc	Waardenburg Syndrome With Hirschsprung Disease Type 4c
Waardenburg Syndrome With Hirschsprung Disease, Type 4c	Waardenburg Syndrome, Type Ivc
Waardenburg Syndrome 4c	Hirschsprung Disease With Pigmentary Anomaly
Shah-Waardenburg Syndrome	Waardenburg-Shah Syndrome
Waardenburg Syndrome, Type 4a

Hair Disease

Hair Diseases	Hair Anomaly
Hair Disorder	Hair Problems

T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome	T-Lymphocyte Deficiency
TIDTA	Immune Defect Due To Absence Of Thymus
Thymic Aplasia	Nezelof'S Syndrome
Thymic Dysplasia With Normal Immunoglobulins	Thymic Aplasia Syndrome
T-Lymphocyte Immunodeficiency

Hypotrichosis 8

HYPT8	Lah3
Hypotrichosis, Localized, Autosomal Recessive 3	Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis
Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis	Hypotrichosis Localized Autosomal Recessive 3
Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis	ARWH1
Hypotrichosis, Type 8

Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

Hypohidrotic Ectodermal Dysplasia	Hed
Anhidrotic Ectodermal Dysplasia	Ectodermal Dysplasia, Hypohidrotic
Eda	Christ-Siemens-Touraine Syndrome
ECTD10B	Ectodermal Dysplasia Anhidrotic
Ectodermal Dysplasia, Anhidrotic	Cst Syndrome
Ectodermal Dysplasia Hypohidrotic Autosomal Recessive	Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive
Dysplasia, Ectodermal, Hypohidrotic	Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive
Ectodermal Dysplasia 3, Anhidrotic	Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07462	KRT71 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KRT71	RGD	RGD:1584538
Bos taurus	KRT71	VGNC	VGNC:30735
Macaca mulatta	KRT71	VGNC	VGNC:74147
Mus musculus	KRT71	MGD	MGI:1861586
Felis catus	KRT71	VGNC	VGNC:63171

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