2. Gene
  3. KRT24 - keratin 24 Gene

KRT24 - keratin 24 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as K24; KA24; CK-24

Gene ID: 192666 | Gene type: protein coding

About KRT24

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,694,246-40,703,752 (from NCBI)

This gene has 1 transcript (splice variant), 114 orthologues and 68 paralogues. Biased expression in esophagus (RPKM 10.1), colon (RPKM 5.1) and 2 other tissues.

Summary

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the Cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jun 2009]

KRT24 Products(1)

mRNA Protein Name
NM_019016.3 NP_061889.2 keratin, type I cytoskeletal 24
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT24 Protein Structure

Filament

Filament: Intermediate filament protein (140 - 452)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 525 a.a.
Protein Preferred Names Protein Names

keratin, type I cytoskeletal 24

cytokeratin-24

KRT24 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra KRT24 Q2M2I5 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra KRT24 Q2M2I5 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra KRT24 Q2M2I5 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
Intra KRT24 Q2M2I5 TRIML2 Homo sapiens Q8N7C3
Validated Y2H
32296183
Intra KRT24 Q2M2I5 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra KRT24 Q2M2I5 KRT80 Homo sapiens Q6KB66-2
Validated Y2H
32296183
Intra KRT24 Q2M2I5 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra KRT24 Q2M2I5 KRT79 Homo sapiens Q5XKE5
Validated Y2H
32296183
Intra KRT24 Q2M2I5 KRT71 Homo sapiens Q3SY84
Validated Y2H
32296183
Intra KRT24 Q2M2I5 AARD Homo sapiens Q4LEZ3
Validated Y2H
32296183
Intra KRT24 Q2M2I5 TCHP Homo sapiens Q9BT92
Validated Y2H
32296183
Intra KRT24 Q2M2I5 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra KRT24 Q2M2I5 SGF29 Homo sapiens Q96ES7
Validated Y2H
32296183
Intra KRT24 Q2M2I5 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra KRT24 Q2M2I5 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Naegeli-Franceschetti-Jadassohn Syndrome

Naegeli Syndrome

Nfj Syndrome

NFJS

Reticular Skin Changes, Dental Anomalies, Decreased Function Of Sweat Glands, Strabismus, And Optic Atrophy

Naegeli-Franceschetti-Jadassohn Syndrome/Dermatopathia Pigmentosa Reticularis

Dpr

Franceschetti-Jadassohn Syndrome

Nfjs/Dpr
Retinitis Pigmentosa 42

RP42

Retinitis Pigmentosa-42

Retinitis Pigmentosa, Type 42
Dermatopathia Pigmentosa Reticularis

DPR
Ectodermal Dysplasia 4, Hair/Nail Type

Pure Hair And Nail Ectodermal Dysplasia

ECTD4

Ectodermal Dysplasia, Pure Hair-Nail Type

Ectodermal Dysplasia, 'Pure' Hair/Nail Type

Hned

Hair-Nail Ectodermal Dysplasia

Phned

Ectodermal Dysplasia Pure Hair-Nail Type

Ectodermal Dysplasia, 'Pure' Hair-Nail Type

Dysplasia, Ectodermal, Type 4, Hair/Nail
Brill-Zinsser Disease

Recrudescent Typhus

Brill Disease

Brill Zinsser Disease

Brill'S Disease

Latent Typhus

Sporadic Typhus

Typhus, Epidemic Louse-Borne

Recrudescent Typhus Due To Rickettsia Prowazekii

Recrudescent Typhus Fever

Recrudescent Brill-Zinsser Typhus Due To Rickettsia Prowazekii

Recrudescent Brill Disease

Recrudescent Typhus Fever Due To Rickettsia Prowazekii
Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07448 KRT24 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KRT24 RGD RGD:1303157
Canis familiaris KRT24 VGNC VGNC:42523
Felis catus KRT24 VGNC VGNC:63170
Mus musculus KRT24 MGD MGI:1922956
Bos taurus KRT24 VGNC VGNC:30723
Macaca mulatta KRT24 VGNC VGNC:99164