CKMT1B - creatine kinase, mitochondrial 1B Gene

Homo sapiens

Also known as CKMT; CKMT1; UMTCK

Gene ID: 1159 | Gene type: protein coding

About CKMT1B

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,592,857-43,599,406 (from NCBI)

This gene has 15 transcripts (splice variants), 217 orthologues and 4 paralogues. Biased expression in colon (RPKM 40.9), duodenum (RPKM 39.5) and 13 other tissues.

Summary

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate Cancer cells via Apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each Other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]

CKMT1B Products(2)

mRNA	Protein	Name
NM_001375484.1	NP_001362413.1	creatine kinase U-type, mitochondrial precursor
NM_020990.5	NP_066270.1	creatine kinase U-type, mitochondrial precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CKMT1B Protein Structure

ATP-gua_PtransN

ATP-gua_Ptrans

0
100
200
300
417 a.a.

Protein Preferred Names

Protein Names

creatine kinase U-type, mitochondrial

U-MtCK

CKMT1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CKMT1A	P12532	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	CKMT1A	P12532	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	CKMT1A	P12532	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	CKMT1A	P12532	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	CKMT1A	P12532	HPCA	Homo sapiens	P84074	Validated Y2H	32296183
Intra	CKMT1A	P12532	PSMC3	Homo sapiens	P17980	Validated Y2H	32296183
Intra	CKMT1A	P12532	NUTF2	Homo sapiens	P61970	Validated Y2H	32296183
Intra	CKMT1A	P12532	PPP1R16A	Homo sapiens	Q96I34	Validated Y2H	32296183
Intra	CKMT1A	P12532	RXRG	Homo sapiens	P48443	Validated Y2H	32296183
Intra	CKMT1A	P12532	CKMT2	Homo sapiens	P17540	Anti Tag CoIP	33961781
Intra	CKMT1A	P12532	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	CKMT1A	P12532	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	CKMT1A	P12532	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	CKMT1A	P12532	ASB9	Homo sapiens	Q96DX5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CKMT1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76264	CKMT1A Protein, Human (sf9, His)	P12532 (A40-H417)	≥95%

Related Diseases

Diseases

Alias

Mitochondrial Complex V Deficiency, Nuclear Type 3

Mitochondrial Complex Iii Deficiency Nuclear Type 5	MC5DN3
Mitochondrial Complex Iii Deficiency, Nuclear Type 5	Mitochondrial Complex V Deficiency Nuclear Type 3
MC3DN5	Mitochondrial Complex V Deficiency, Atp5e Type
Mitochondrial Complex Iii Deficiency, Nuclear 5	Mitochondrial Complex V Deficiency, Nuclear Type 3
Mitochondrial Complex V Deficiency Atp5e Type	Mitochondrial Complex V Deficiency Type 3
Mitochondrial Complex V Deficiency, Nuclear, Type 3

Cardiomyopathy, Dilated, 1ee

Dilated Cardiomyopathy 1ee	CMD1EE
Cardiomyopathy, Dilated 1ee	Cardiomyopathy, Dilated, Type 1ee

Cerebral Creatine Deficiency Syndrome

Deficiency, Cerebral Creatine, Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02740	CKMT1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CKMT1B	MGD	MGI:99441
Rattus norvegicus	CKMT1B	RGD	RGD:61976

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