PSMC3 - proteasome 26S subunit, ATPase 3 Gene

Homo sapiens

Also known as RPT5; TBP1; DCIDP

Gene ID: 5702 | Gene type: protein coding

About PSMC3

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,418,775-47,426,439 (from NCBI)

This gene has 13 transcripts (splice variants), 220 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 35.4), brain (RPKM 35.2) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

PSMC3 Products(1)

mRNA	Protein	Name
NM_002804.5	NP_002795.2	26S proteasome regulatory subunit 6A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in modulation by host of viral transcription	IDA IDA: Inferred from direct assay	2194290	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19853614	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	2194290	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	9464850	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMC3 Protein Structure

AAA

0
100
200
300
400
439 a.a.

Protein Preferred Names

Protein Names

26S proteasome regulatory subunit 6A

26S protease regulatory subunit 6A

PSMC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	PSMC3	P17980	CKMT1A	Homo sapiens	P12532	Y2H Array	32296183
Intra	PSMC3	P17980	CKMT1A	Homo sapiens	P12532	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	NDUFAB1	Homo sapiens	O14561	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	NDUFAB1	Homo sapiens	O14561	Y2H Array	32296183
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Y2H Prey Pooling	25416956
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	35271311
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	28514442
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	19490896
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Validated Y2H	25416956
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Validated Y2H	32296183
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Y2H Array	25416956
Intra	PSMC3	P17980	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Anti Tag CoIP	19490896
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Array	31515488
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Prey Pooling	25416956
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Array	25416956
Intra	PSMC3	P17980	TRAF4	Homo sapiens	Q9BUZ4	Anti Tag CoIP	28514442
Intra	PSMC3	P17980	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	PSMC3	P17980	TRAF4	Homo sapiens	Q9BUZ4	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PSMC3	P17980	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PSMC3	P17980	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Validated Y2H	32296183
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Y2H Array	32296183
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Anti Tag CoIP	28514442
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	DPY30	Homo sapiens	Q9C005	Validated Y2H	32296183
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Anti Tag CoIP	35271311
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Array	32296183
Intra	PSMC3	P17980	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	PSMC3	P17980	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	PSMC3	P17980	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	PSMC3	P17980	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	PSMC3	P17980	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	PSMC3	P17980	SNCA	Homo sapiens	P37840	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Cataract, Impaired Intellectual Development, And Polyneuropathy

DCIDP

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Polyneuropathy

Polyneuropathies

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11312	PSMC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11313	PSMC3IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PSMC3	MGD	MGI:1098754
Rattus norvegicus	PSMC3	RGD	RGD:61905
Macaca mulatta	PSMC3	VGNC	VGNC:101385
Felis catus	PSMC3	VGNC	VGNC:69113
Bos taurus	PSMC3	VGNC	VGNC:33456

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