NUTF2 - nuclear transport factor 2 Gene

Homo sapiens

Also known as NTF2; PP15; NTF-2

Gene ID: 10204 | Gene type: protein coding

About NUTF2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,846,933-67,872,567 (from NCBI)

This gene has 14 transcripts (splice variants), 235 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 14.8), testis (RPKM 14.7) and 25 other tissues.

Summary

This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]

NUTF2 Products(5)

mRNA	Protein	Name
NM_001322038.2	NP_001308967.1	nuclear transport factor 2
NM_001322039.2	NP_001308968.1	nuclear transport factor 2
NM_001322040.2	NP_001308969.1	nuclear transport factor 2
NM_001322041.2	NP_001308970.1	nuclear transport factor 2
NM_005796.3	NP_005787.1	nuclear transport factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19098896	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7744965	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	10679025	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	18266911	GOA
enables structural constituent of nuclear pore	IDA IDA: Inferred from direct assay	7744965	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	16449645	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	7744965	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	7744965	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	10679025	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUTF2 Protein Structure

NTF2

0
100
127 a.a.

Protein Preferred Names

Protein Names

nuclear transport factor 2

placental protein 15

NUTF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUTF2	P61970	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	NUTF2	P61970	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	32296183
Intra	NUTF2	P61970	PAX4	Homo sapiens	Q3KNR5	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	PAX4	Homo sapiens	Q3KNR5	Validated Y2H	32296183
Intra	NUTF2	P61970	PAX4	Homo sapiens	Q3KNR5	Y2H Array	32296183
Intra	NUTF2	P61970	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	NUTF2	P61970	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	NUTF2	P61970	NRIP3	Homo sapiens	Q9NQ35	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	NRIP3	Homo sapiens	Q9NQ35	Validated Y2H	32296183
Intra	NUTF2	P61970	NRIP3	Homo sapiens	Q9NQ35	Y2H Array	32296183
Intra	NUTF2	P61970	CKMT1A	Homo sapiens	P12532	Y2H Array	32296183
Intra	NUTF2	P61970	CKMT1A	Homo sapiens	P12532	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	CLPP	Homo sapiens	Q16740	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	CLPP	Homo sapiens	Q16740	Validated Y2H	32296183
Intra	NUTF2	P61970	CLPP	Homo sapiens	Q16740	Y2H Array	32296183
Intra	NUTF2	P61970	BRWD1	Homo sapiens	Q9NSI6-4	Validated Y2H	32296183
Intra	NUTF2	P61970	BRWD1	Homo sapiens	Q9NSI6-4	Y2H Array	32296183
Intra	NUTF2	P61970	BRWD1	Homo sapiens	Q9NSI6-4	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	NUTF2	P61970	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	NUTF2	P61970	LCE5A	Homo sapiens	Q5TCM9	Validated Y2H	32296183
Intra	NUTF2	P61970	LCE5A	Homo sapiens	Q5TCM9	Y2H Array	32296183
Intra	NUTF2	P61970	LCE5A	Homo sapiens	Q5TCM9	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Array	32296183
Intra	NUTF2	P61970	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	NUTF2	P61970	SPATC1L	Homo sapiens	Q9H0A9-2	Validated Y2H	32296183
Intra	NUTF2	P61970	SPATC1L	Homo sapiens	Q9H0A9-2	Y2H Array	32296183
Intra	NUTF2	P61970	SPATC1L	Homo sapiens	Q9H0A9-2	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	CAMK2G	Homo sapiens	Q13555-5	Y2H Array	32296183
Intra	NUTF2	P61970	CAMK2G	Homo sapiens	Q13555-5	Validated Y2H	32296183
Intra	NUTF2	P61970	CAMK2G	Homo sapiens	Q13555-5	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	YAF2	Homo sapiens	Q8IY57-5	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	YAF2	Homo sapiens	Q8IY57-5	Y2H Array	32296183
Intra	NUTF2	P61970	YAF2	Homo sapiens	Q8IY57-5	Validated Y2H	32296183
Intra	NUTF2	P61970	CHMP4A	Homo sapiens	Q9BY43-2	Validated Y2H	32296183
Intra	NUTF2	P61970	CHMP4A	Homo sapiens	Q9BY43-2	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	CHMP4A	Homo sapiens	Q9BY43-2	Y2H Array	32296183
Intra	NUTF2	P61970	LCE1C	Homo sapiens	Q5T751	Validated Y2H	32296183
Intra	NUTF2	P61970	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	NUTF2	P61970	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	CCDC150	Homo sapiens	Q8NCX0-3	Validated Y2H	32296183
Intra	NUTF2	P61970	CCDC150	Homo sapiens	Q8NCX0-3	Y2H Array	32296183
Intra	NUTF2	P61970	CCDC150	Homo sapiens	Q8NCX0-3	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	TEX35	Homo sapiens	Q5T0J7-2	Validated Y2H	32296183
Intra	NUTF2	P61970	TEX35	Homo sapiens	Q5T0J7-2	Y2H Array	32296183
Intra	NUTF2	P61970	TEX35	Homo sapiens	Q5T0J7-2	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	THAP3	Homo sapiens	Q8WTV1	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	THAP3	Homo sapiens	Q8WTV1	Y2H Array	32296183
Intra	NUTF2	P61970	THAP3	Homo sapiens	Q8WTV1	Validated Y2H	32296183
Intra	NUTF2	P61970	UBAP2	Homo sapiens	Q5T6F2	Validated Y2H	32296183
Intra	NUTF2	P61970	UBAP2	Homo sapiens	Q5T6F2	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	UBAP2	Homo sapiens	Q5T6F2	Y2H Array	32296183
Intra	NUTF2	P61970	ZMAT2	Homo sapiens	Q96NC0	Y2H Array	32296183
Intra	NUTF2	P61970	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	32296183
Intra	NUTF2	P61970	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	MRNIP	Homo sapiens	Q6NTE8	Validated Y2H	32296183
Intra	NUTF2	P61970	MRNIP	Homo sapiens	Q6NTE8	Y2H Array	32296183
Intra	NUTF2	P61970	MRNIP	Homo sapiens	Q6NTE8	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	PHF11	Homo sapiens	Q9UIL8	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	PHF11	Homo sapiens	Q9UIL8	Validated Y2H	32296183
Intra	NUTF2	P61970	PHF11	Homo sapiens	Q9UIL8	Y2H Array	32296183
Intra	NUTF2	P61970	RAN	Homo sapiens	P62826	Comig Non-Denat Gel	19098896
Intra	NUTF2	P61970	RAN	Homo sapiens	P62826	Anti Tag CoIP	35271311
Intra	NUTF2	P61970	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	NUP62	Homo sapiens	P37198	Y2H Array	31515488
Intra	NUTF2	P61970	NUP62	Homo sapiens	P37198	Validated Y2H	25416956
Intra	NUTF2	P61970	NUP62	Homo sapiens	P37198	Y2H Array	32296183
Intra	NUTF2	P61970	NUP62	Homo sapiens	P37198	Y2H Array	25416956
Intra	NUTF2	P61970	SPRY4	Homo sapiens	Q9C004	Validated Y2H	32296183
Intra	NUTF2	P61970	SPRY4	Homo sapiens	Q9C004	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	SPRY4	Homo sapiens	Q9C004	Y2H Array	32296183
Intra	NUTF2	P61970	PCNA	Homo sapiens	P12004	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	PCNA	Homo sapiens	P12004	Y2H Array	32296183
Intra	NUTF2	P61970	PFKP	Homo sapiens	Q01813	Validated Y2H	32296183
Intra	NUTF2	P61970	PFKP	Homo sapiens	Q01813	Y2H Array	32296183
Intra	NUTF2	P61970	PFKP	Homo sapiens	Q01813	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	MYOZ3	Homo sapiens	Q8TDC0	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	NUTF2	P61970	MYOZ3	Homo sapiens	Q8TDC0	Y2H Array	32296183
Intra	NUTF2	P61970	NUTF2	Homo sapiens	P61970	Comig Non-Denat Gel	19098896
Intra	NUTF2	P61970	NUTF2	Homo sapiens	P61970	Y2H Array	25416956
Intra	NUTF2	P61970	NUTF2	Homo sapiens	P61970	GMS	19098896
Intra	NUTF2	P61970	PPP1R16A	Homo sapiens	Q96I34	Validated Y2H	32296183
Intra	NUTF2	P61970	PPP1R16A	Homo sapiens	Q96I34	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	PPP1R16A	Homo sapiens	Q96I34	Y2H Array	32296183
Intra	NUTF2	P61970	CCDC106	Homo sapiens	Q9BWC9	Y2H Array	32296183
Intra	NUTF2	P61970	CCDC106	Homo sapiens	Q9BWC9	Validated Y2H	32296183
Intra	NUTF2	P61970	CCDC106	Homo sapiens	Q9BWC9	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	HMG20B	Homo sapiens	Q9P0W2	Y2H Array	32296183
Intra	NUTF2	P61970	HMG20B	Homo sapiens	Q9P0W2	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	HMG20B	Homo sapiens	Q9P0W2	Validated Y2H	32296183
Intra	NUTF2	P61970	LENG1	Homo sapiens	Q96BZ8	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	LENG1	Homo sapiens	Q96BZ8	Validated Y2H	32296183
Intra	NUTF2	P61970	LENG1	Homo sapiens	Q96BZ8	Y2H Array	32296183
Intra	NUTF2	P61970	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	32296183
Intra	NUTF2	P61970	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
Intra	NUTF2	P61970	NUP54	Homo sapiens	Q7Z3B4	Validated Y2H	32296183
Intra	NUTF2	P61970	NUP54	Homo sapiens	Q7Z3B4	Y2H Array	32296183
Intra	NUTF2	P61970	NUP54	Homo sapiens	Q7Z3B4	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	NME1	Homo sapiens	P15531	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	NME1	Homo sapiens	P15531	Y2H Array	32296183
Intra	NUTF2	P61970	FAM50B	Homo sapiens	Q9Y247	Validated Y2H	32296183
Intra	NUTF2	P61970	FAM50B	Homo sapiens	Q9Y247	Y2H Array	32296183
Intra	NUTF2	P61970	FAM50B	Homo sapiens	Q9Y247	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	CHCHD3	Homo sapiens	Q9NX63	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	CHCHD3	Homo sapiens	Q9NX63	Validated Y2H	32296183
Intra	NUTF2	P61970	CHCHD3	Homo sapiens	Q9NX63	Y2H Array	32296183
Intra	NUTF2	P61970	NME4	Homo sapiens	O00746	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	NME4	Homo sapiens	O00746	Y2H Array	32296183
Intra	NUTF2	P61970	RPRD1B	Homo sapiens	Q9NQG5	Validated Y2H	32296183
Intra	NUTF2	P61970	RPRD1B	Homo sapiens	Q9NQG5	Y2H Array	32296183
Intra	NUTF2	P61970	RPRD1B	Homo sapiens	Q9NQG5	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	NUTF2	P61970	LASP1	Homo sapiens	Q14847-2	Validated Y2H	32296183
Intra	NUTF2	P61970	KHDC4	Homo sapiens	Q7Z7F0-4	Validated Y2H	32296183
Intra	NUTF2	P61970	KHDC4	Homo sapiens	Q7Z7F0-4	Y2H Array	32296183
Intra	NUTF2	P61970	KHDC4	Homo sapiens	Q7Z7F0-4	Y2H Prey Pooling	32296183
Intra	NUTF2	P61970	KRT86	Homo sapiens	O43790	Y2H Array	32296183
Intra	NUTF2	P61970	KRT86	Homo sapiens	O43790	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09705	NUTF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NUTF2	VGNC	VGNC:97543
Rattus norvegicus	NUTF2	RGD	RGD:1359213
Mus musculus	NUTF2	MGD	MGI:1915301
Bos taurus	NUTF2	VGNC	VGNC:32371

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