2. Gene
  3. Il13 - interleukin 13 Gene

Il13 - interleukin 13 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 116553 | Gene type: protein coding

About Il13

Primary_assembly 10: 37,790,130-37,792,737 reverse strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 88 orthologues and is associated with 99 phenotypes. Restricted expression toward (RPKM 4.2).

Summary

Enables interleukin-13 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and regulation of cation transmembrane transport. Located in extracellular space. Used to study asthma; extrinsic allergic alveolitis; and lipoid nephrosis. Biomarker of several diseases, including alcoholic hepatitis; middle cerebral artery infarction; peptic esophagitis; prostatic hypertrophy; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13). [provided by Alliance of Genome Resources, Apr 2022]

Il13 Products(1)

mRNA Protein Name
NM_053828.1 NP_446280.1 interleukin-13 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables interleukin-13 receptor binding IPI
IPI: Inferred from physical interaction
11573960 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
18362439 RGD
involved in microglial cell activation IMP
IMP: Inferred from mutant phenotype
19752235 RGD
involved in negative regulation of NAD(P)H oxidase activity IMP
IMP: Inferred from mutant phenotype
19752235 RGD
involved in negative regulation of transforming growth factor beta production IDA
IDA: Inferred from direct assay
20100461 RGD
involved in positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
10331006 RGD
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
18941241 RGD
involved in positive regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
11573960 RGD
involved in positive regulation of monoatomic ion transport IDA
IDA: Inferred from direct assay
11739109 RGD
involved in positive regulation of pancreatic stellate cell proliferation IDA
IDA: Inferred from direct assay
20100461 RGD
involved in positive regulation of protein secretion IDA
IDA: Inferred from direct assay
11739109 RGD
involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
20045483 RGD
involved in positive regulation of smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
20045483 RGD
involved in regulation of proton transport IDA
IDA: Inferred from direct assay
11739109 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16698589 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
16522370 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
18490768 RGD
involved in response to nicotine IDA
IDA: Inferred from direct assay
18490768 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
17429054 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il13 Protein Structure

IL13

IL13: pfam03487 (20 - 130)

  • 0
  • 100
  • 131 a.a.
Protein Preferred Names Protein Names

interleukin-13

IL-13

T-cell activation protein P600

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0539 Desloratadine 99.88% Yes
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9926 Dupilumab Inhibitor ≥99.2% Unkown
HY-P99025 Lebrikizumab Inhibitor 99.90% Unkown
HY-P99053 Tralokinumab Inhibitor 99.12% Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-144683 PF-07038124 Inhibitor / Phase 2
Inhibitory Antibodies (12)
Cat. No. Product Name Effect
Purity Phase
HY-P990093 Stapokibart Inhibitor 96.34% Phase 3
HY-P99496 Cendakimab Inhibitor 99.96% Phase 3
HY-P990090 Rademikibart Inhibitor 98.69% Phase 3
HY-P99870 Eblasakimab ≥99.0% Phase 2
HY-P990748 Lunsekimig 98.00% Phase 2
HY-P99439 Anrukinzumab Inhibitor 98.64% Phase 2
HY-P990594 GSK-679586 Inhibitor / Phase 2
HY-P99846 Dectrekumab / Phase 2
HY-P99883 Romilkimab / Phase 2
HY-P99417 Abrezekimab Inhibitor 95.00% Phase 1
HY-P990602 IMA-026 Inhibitor / Phase 1
HY-P990735 Donzakimig / Phase 1
Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126360 Oxazolone ≥98.0% Unkown
HY-125019 iJak-381 Inhibitor 99.86% Unkown
HY-162248 JAK1/2-IN-1 Inhibitor 98.36% Unkown
HY-110295 SPL-334 Inhibitor / Unkown
HY-144683A PF-07038124 hydrochloride Inhibitor / Unkown
HY-144684 PDE4-IN-8 Inhibitor / Unkown
HY-165484 AVP-13358 Inhibitor / Unkown
HY-P10292 NOTA-Pep-1L / Unkown
HY-RS06685 IL13 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06686 Il13 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06687 Il13 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06688 IL13RA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06689 IL13RA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-124613 Pyrazinib Inhibitor / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990442 Anti-IL-13 Antibody (CNTO 607) Inhibitor / Unkown
HY-P990445 Anti-IL-13Ra2/CD213a2 Inhibitor / Unkown
HY-P990699 Riltovetbart / Unkown
HY-P990741 Galvokimig / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il13 NCBI NCBI:3596
Canis familiaris Il13 NCBI NCBI:442990
Macaca fascicularis Il13 NCBI NCBI:102125887
Mus musculus Il13 NCBI NCBI:16163