Il13 - interleukin 13 Gene

Mus musculus

Also known as Il-13

Gene ID: 16163 | Gene type: protein coding

About Il13

Chromosome 11: 53,522,151-53,525,529 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 88 orthologues and is associated with 55 phenotypes. Biased expression in thymus adult (RPKM 2.8), testis adult (RPKM .6) and 2 other tissues.

Summary

Predicted to enable interleukin-13 receptor binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation. Acts upstream of or within cellular response to cytokine stimulus; inflammatory response; and positive regulation of immune effector process. Located in cytoplasm; external side of plasma membrane; and extracellular space. Is expressed in gut; liver; male reproductive gland or organ; and thymus. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13). [provided by Alliance of Genome Resources, Apr 2022]

Il13 Products(1)

mRNA	Protein	Name
NM_008355.3	NP_032381.1	interleukin-13 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23972995	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	19666510	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	15647285	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	24906148	MGI
acts upstream of or within positive regulation of immunoglobulin production	IGI IGI: Inferred from genetic interaction	15944273	MGI
acts upstream of or within positive regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	15944273	MGI
involved in positive regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	19841166	MGI
acts upstream of or within positive regulation of mast cell degranulation	IGI IGI: Inferred from genetic interaction	15944273	MGI
acts upstream of or within positive regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	15944273	MGI
acts upstream of or within response to nematode	IDA IDA: Inferred from direct assay	26644468	MGI
acts upstream of or within response to selenium ion	IDA IDA: Inferred from direct assay	26644468	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11737071	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	18792410	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	15087456	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il13 Protein Structure

IL13

0
100
131 a.a.

Protein Preferred Names

Protein Names

interleukin-13

T-cell activation protein P600

Il13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Il13	P20109	Il13ra2	Mus musculus	O88786	Anti Bait CoIP	27629921
Intra	Il13	P20109	Il13ra2	Mus musculus	O88786	Anti Bait CoIP	23972995

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Il13 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7076A	IL-13 Protein, Mouse (CHO, His)	P20109 (P22-F131)	≥95%
HY-P70460	IL-13 Protein, Mouse	P20109 (S26-F131)	≥95%
HY-P72595	IL-13 Protein, Mouse (HEK293, His)	P20109 (P22-F131)	≥95%
HY-P73168	IL-13 Protein, Mouse (HEK293)	P20109 (A19-F131)	≥95%
HY-P700192AF	Animal-Free IL-13 Protein, Mouse (His)	P20109 (P22-F131)	≥95%

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0539	Desloratadine		99.83%	Yes

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9926	Dupilumab	Inhibitor	≥99.2%	Unkown
HY-P99025	Lebrikizumab	Inhibitor	99.90%	Unkown
HY-P99053	Tralokinumab	Inhibitor	97.59%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-144683	PF-07038124	Inhibitor	/	Phase 2

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99496	Cendakimab	Inhibitor	99.96%	Phase 3
HY-P990093	Stapokibart	Inhibitor	96.34%	Phase 3
HY-P990090	Rademikibart	Inhibitor	/	Phase 3
HY-P99870	Eblasakimab		≥99.0%	Phase 2
HY-P99439	Anrukinzumab	Inhibitor	98.64%	Phase 2
HY-P99846	Dectrekumab		/	Phase 2
HY-P99883	Romilkimab		/	Phase 2
HY-P99417	Abrezekimab	Inhibitor	95.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126360	Oxazolone		≥98.0%	Unkown
HY-125019	iJak-381	Inhibitor	99.86%	Unkown
HY-110295	SPL-334	Inhibitor	/	Unkown
HY-144683A	PF-07038124 hydrochloride	Inhibitor	/	Unkown
HY-144684	PDE4-IN-8	Inhibitor	/	Unkown
HY-162248	JAK1/2-IN-1	Inhibitor	/	Unkown
HY-165484	AVP-13358	Inhibitor	/	Unkown
HY-P10292	NOTA-Pep-1L		/	Unkown
HY-RS06685	IL13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06686	Il13 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06687	Il13 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06688	IL13RA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06689	IL13RA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124613	Pyrazinib	Inhibitor	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-P990748	Lunsekimig	/	Unkown
HY-P990699	Riltovetbart	/	Unkown
HY-P990735	Donzakimig	/	Unkown
HY-P990741	Galvokimig	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il13	NCBI	NCBI:3596
Canis familiaris	Il13	NCBI	NCBI:442990
Macaca fascicularis	Il13	NCBI	NCBI:102125887
Rattus norvegicus	Il13	NCBI	NCBI:116553

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