LRG1 - leucine rich alpha-2-glycoprotein 1 Gene

Homo sapiens

Also known as LRG; HMFT1766

Gene ID: 116844 | Gene type: protein coding

About LRG1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,536,402-4,540,036 (from NCBI)

This gene has 2 transcripts (splice variants), 289 orthologues and 22 paralogues. Biased expression in liver (RPKM 150.7), esophagus (RPKM 16.6) and 4 other tissues.

Summary

The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]

LRG1 Products(1)

mRNA	Protein	Name
NM_052972.3	NP_443204.1	leucine-rich alpha-2-glycoprotein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23868260	GOA
enables type I transforming growth factor beta receptor binding	IPI IPI: Inferred from physical interaction	23868260	GOA
enables type II transforming growth factor beta receptor binding	IPI IPI: Inferred from physical interaction	23868260	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of keratinocyte migration	IMP IMP: Inferred from mutant phenotype	32887674	GOA
acts upstream of leukocyte adhesion to vascular endothelial cell	IMP IMP: Inferred from mutant phenotype	32887674	GOA
acts upstream of positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	32887674	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	23868260	GOA
acts upstream of positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	23868260	GOA
acts upstream of positive regulation of epithelial cell proliferation involved in wound healing	IMP IMP: Inferred from mutant phenotype	32887674	GOA
involved in positive regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	32887674	GOA
acts upstream of positive regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	32887674	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	23868260	GOA
acts upstream of or within wound healing, spreading of epidermal cells	IMP IMP: Inferred from mutant phenotype	32887674	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	20363744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRG1 Protein Structure

LRR_1

LRR_8

LRR_1

LRR_8

0
100
200
300
347 a.a.

Protein Preferred Names

Protein Names

leucine-rich alpha-2-glycoprotein

1300008B03Rik

LRG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LRG1	P02750	ENG	Homo sapiens	P17813-1	Anti Bait CoIP	23868260
Intra	LRG1	P02750	ENG	Homo sapiens	P17813-1	SPR	23868260
Intra	LRG1	P02750	TGFBR2	Homo sapiens	P37173-2	Anti Bait CoIP	23868260
Intra	LRG1	P02750	TGFBR1	Homo sapiens	P36897-1	Anti Bait CoIP	23868260
Intra	LRG1	P02750	CYCS	Homo sapiens	P99999	Anti Tag CoIP	33961781
Intra	LRG1	P02750	CYCS	Homo sapiens	P99999	Anti Tag CoIP	28514442
Intra	LRG1	P02750	ACVRL1	Homo sapiens	P37023	Anti Bait CoIP	23868260

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70166	LRG1 Protein, Human (HEK293, His)	AAH34389.1 (V36-Q347)	≥95%
HY-P70175	LRG1 Protein, Human (HEK293, Fc-His)	P02750/AAH70198.1 (V36-Q347)	≥95%

Related Diseases

Diseases

Alias

Appendicitis

Acute Appendicitis	Acute Appendicitis With Generalized Peritonitis
Acute Appendicitis Nos	Acute Appendicitis With Peritoneal Abscess
Appendiceal Inflammation	Appendicitis, Unqualified
Acute Appendix Inflammation	Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation
Acute Appendicitis With Free Peritonitis	Acute Appendicitis With Free Perforation To The Abdominal Cavity
Perforated Appendix With Generalised Peritonitis	Appendicitis With Perforation And Free Pus In The Peritoneal Cavity
Perforated Appendix With Localised Peritonitis	Acute Appendicitis With Contained Perforation To A Localised Abscess
Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation	Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation
Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess	Appendicitis With Abscess
Appendicitis With Peritoneal Abscess	Ruptured Appendix Nos
Acute Appendicitis With No Perforation Or Abscess And No Visible Pus	Acute Appendicitis With No Specification If Perforated Or Not
Acute Appendicitis With Phlegmone

Cecal Disease

Cecal Diseases

Disorder Of Cecum

Communicating Hydrocephalus

Acquired Communicating Hydrocephalus

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive	Hydrocephalus, X-Linked
Hydrocephalus Adverse Event	Hydrocephaly Nos

Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus	Hydrocephalus Normal Pressure
Hydrocephalus, Normal Pressure	Normal Pressure Hydrocephalus Nos
Nph - [Normal Pressure Hydrocephalus]	Normal Pressure Hydrocephaly

Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9	Left Ventricular Noncompaction 5
Dilated Cardiomyopathy 1e	Dilated Cardiomyopathy 1s
CMD1E	Cdcd2
Cardiomyopathy, Dilated, 1y	CMD1Y
Cardiomyopathy, Dilated, 1s	CMD1S
Dilated Cardiomyopathy 1y	Dilated Cardiomyopathy With Conduction Defect 2
Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia	Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia
Cardiomyopathy, Dilated, With Conduction Defect 2	Cardiomyopathy Dilated With Conduction Defect Type 2
Cardiomyopathy, Dilated 1e	Cardiomyopathy, Dilated 1s
Cardiomyopathy, Dilated 1y	Left Ventricular Non-Compaction 5
LVNC5	Left Ventricular Non-Compaction 9
LVNC9	Cardiomyopathy, Dilated, Type 1e
Cardiomyopathy, Dilated, Type 1s	Cardiomyopathy, Dilated, Type 1y

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07784	LRG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRG1	RGD	RGD:1359464
Macaca mulatta	LRG1	VGNC	VGNC:74394
Bos taurus	LRG1	VGNC	VGNC:30980
Felis catus	LRG1	VGNC	VGNC:102630
Canis familiaris	LRG1	VGNC	VGNC:42765
Mus musculus	LRG1	MGD	MGI:1924155
Macaca fascicularis	LRG1	NCBI	NCBI:102118680
Others	LRG1	NCBI

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