2. Gene
  3. IP6K3 - inositol hexakisphosphate kinase 3 Gene

IP6K3 - inositol hexakisphosphate kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as IHPK3; INSP6K3

Gene ID: 117283 | Gene type: protein coding

About IP6K3

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:33,721,662-33,762,145 (from NCBI)

This gene has 3 transcripts (splice variants), 138 orthologues and 6 paralogues. Broad expression in thyroid (RPKM 4.4), heart (RPKM 3.1) and 14 other tissues.

Summary

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]

IP6K3 Products(2)

mRNA Protein Name
NM_001142883.2 NP_001136355.1 inositol hexakisphosphate kinase 3
NM_054111.5 NP_473452.2 inositol hexakisphosphate kinase 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables inositol hexakisphosphate 6-kinase activity IDA
IDA: Inferred from direct assay
11502751 GOA
enables inositol hexakisphosphate kinase activity IDA
IDA: Inferred from direct assay
11502751 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within inositol phosphate biosynthetic process IDA
IDA: Inferred from direct assay
11502751 GOA
involved in phosphatidylinositol metabolic process IDA
IDA: Inferred from direct assay
11502751 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11502751 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11502751 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IP6K3 Protein Structure

IPK

IPK: Inositol polyphosphate kinase (198 - 404)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
Protein Preferred Names Protein Names

inositol hexakisphosphate kinase 3

ATP:1D-myo-inositol-hexakisphosphate phosphotransferase

IP6K3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra IP6K3 Q96PC2 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra IP6K3 Q96PC2 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra IP6K3 Q96PC2 NOTO Homo sapiens A8MTQ0
Y2H Array
32296183
Intra IP6K3 Q96PC2 NOTO Homo sapiens A8MTQ0
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra IP6K3 Q96PC2 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 MED4 Homo sapiens Q9NPJ6
Y2H Array
32296183
Intra IP6K3 Q96PC2 MED4 Homo sapiens Q9NPJ6
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 MED4 Homo sapiens Q9NPJ6
Validated Y2H
32296183
Intra IP6K3 Q96PC2 POLR2E Homo sapiens P19388
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 POLR2E Homo sapiens P19388
Y2H Array
32296183
Intra IP6K3 Q96PC2 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra IP6K3 Q96PC2 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra IP6K3 Q96PC2 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra IP6K3 Q96PC2 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra IP6K3 Q96PC2 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
32296183
Intra IP6K3 Q96PC2 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
32296183
Intra IP6K3 Q96PC2 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra IP6K3 Q96PC2 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra IP6K3 Q96PC2 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153530 LI-2242 98.95% Unkown
HY-122706 TBK1/IKKε-IN-3 / Unkown
HY-RS06863 IP6K3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IP6K3 VGNC VGNC:107290
Mus musculus IP6K3 MGD MGI:3045325
Felis catus IP6K3 VGNC VGNC:102444
Canis familiaris IP6K3 VGNC VGNC:42063
Macaca mulatta IP6K3 VGNC VGNC:81083
Rattus norvegicus IP6K3 RGD RGD:1584104