2. Gene
  3. POLR2E - RNA polymerase II, I and III subunit E Gene

POLR2E - RNA polymerase II, I and III subunit E Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RPB5; XAP4; RPABC1; hRPB25; hsRPB5

Gene ID: 5434 | Gene type: protein coding

About POLR2E

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,086,574-1,095,375 (from NCBI)

This gene has 14 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in fat (RPKM 46.7), kidney (RPKM 21.6) and 25 other tissues.

Summary

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the Other two DNA-directed RNA polymerases and is present in two-fold molar excess over the Other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

POLR2E Products(3)

mRNA Protein Name
NM_001316323.2 NP_001303252.1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform b
NM_001316324.2 NP_001303253.1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform b
NM_002695.5 NP_002686.3 DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12737519 GOA
Biological Process GO Annotation Evidence Reference Source
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9852112 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase I complex IDA
IDA: Inferred from direct assay
34671025 GOA
part of RNA polymerase II, core complex IDA
IDA: Inferred from direct assay
9852112 GOA
part of RNA polymerase III complex IDA
IDA: Inferred from direct assay
33335104 GOA
part of RPAP3/R2TP/prefoldin-like complex IPI
IPI: Inferred from physical interaction
31738558 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9852112 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR2E Protein Structure

RNA_pol_Rpb5_N

RNA_pol_Rpb5_N: RNA polymerase Rpb5, N-terminal domain (1 - 95)

RNA_pol_Rpb5_C

RNA_pol_Rpb5_C: RNA polymerase Rpb5, C-terminal domain (137 - 209)

  • 0
  • 100
  • 210 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerases I, II, and III subunit RPABC1

DNA directed RNA polymerase II 23 kda polypeptide

POLR2E Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
POLR2E P19388 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
Intra
POLR2E P19388 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
Intra
POLR2E P19388 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
Intra
POLR2E P19388 IP6K3 Homo sapiens Q96PC2
Y2H Array
32296183
Intra
POLR2E P19388 IP6K3 Homo sapiens Q96PC2
Validated Y2H
32296183
Intra
POLR2E P19388 IP6K3 Homo sapiens Q96PC2
Y2H Prey Pooling
32296183
Intra
POLR2E P19388 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
POLR2E P19388 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
POLR2E P19388 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
POLR2E P19388 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra
POLR2E P19388 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra
POLR2E P19388 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra
POLR2E P19388 F13A1 Homo sapiens P00488
Validated Y2H
32814053
Intra
POLR2E P19388 F13A1 Homo sapiens P00488
Y2H Array
32814053
Intra
POLR2E P19388 F13A1 Homo sapiens P00488
Y2H Pooling
32814053
Intra
POLR2E P19388 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra
POLR2E P19388 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra
POLR2E P19388 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra
POLR2E P19388 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
POLR2E P19388 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
POLR2E P19388 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
POLR2E P19388 URI1 Homo sapiens O94763
Anti Tag CoIP
33961781
Intra
POLR2E P19388 URI1 Homo sapiens O94763
Pull Down
12737519
Intra
POLR2E P19388 URI1 Homo sapiens O94763
TAP
24981860
Intra
POLR2E P19388 URI1 Homo sapiens O94763
Anti Tag CoIP
35271311
Intra
POLR2E P19388 GTF2B Homo sapiens Q00403
3D-EM
27193682
Intra
POLR2E P19388 GTF2B Homo sapiens Q00403
Anti Tag CoIP
35271311
Intra
POLR2E P19388 UBE2D4 Homo sapiens Q9Y2X8
Validated Y2H
32296183
Intra
POLR2E P19388 DR1 Homo sapiens Q01658
Y2H Pooling
32814053
Intra
POLR2E P19388 DR1 Homo sapiens Q01658
Validated Y2H
32814053
Intra
POLR2E P19388 DR1 Homo sapiens Q01658
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

POLR2E Antibodies

Cat. No. Product Name Application Reactivity
HY-P81939 RNA Polymerases I/II/III Subunit ABC1 Antibody (YA1684) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10846 POLR2E Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris POLR2E VGNC VGNC:44796
Macaca mulatta POLR2E VGNC VGNC:76214
Rattus norvegicus POLR2E RGD RGD:1589817
Mus musculus POLR2E MGD MGI:1913670
Bos taurus POLR2E VGNC VGNC:33139
Felis catus POLR2E VGNC VGNC:68950