Lrrc7 - leucine rich repeat containing 7 Gene

Rattus norvegicus

Gene ID: 117284 | Gene type: protein coding

About Lrrc7

Summary

Enables protein C-terminus binding activity. Involved in positive regulation of neuron projection development and response to organic cyclic compound. Located in several cellular components, including axon initial segment; dendritic spine; and postsynaptic density. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Colocalizes with actin Cytoskeleton. Orthologous to human LRRC7 (leucine rich repeat containing 7). [provided by Alliance of Genome Resources, Apr 2022]

Lrrc7 Products(2)

mRNA	Protein	Name
NM_001393674.1	NP_001380603.1	leucine-rich repeat-containing protein 7 isoform 1
NM_057142.2	NP_476483.1	leucine-rich repeat-containing protein 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12390249	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16120608	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	15647492	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19038319	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	18248607	RGD
located in axon initial segment	IDA IDA: Inferred from direct assay	8824323	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	8824323	RGD
located in filopodium	IDA IDA: Inferred from direct assay	18248607	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	8824323	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	8824323	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leucine-rich repeat-containing protein 7

densin 13T-16	densin 13T-17
densin 13T-23	densin 13T-29
densin 13T-41	densin 13T-43
densin 13T-57	densin 13T-57C
densin 13T-72	densin 13T-89
densin-180

Lrrc7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Lrrc7	P70587	Camk2a	Rattus norvegicus	P11275	Anti Bait CoIP	16120608
Intra	Lrrc7	P70587	Dlg4	Rattus norvegicus	P31016	Anti Tag CoIP	12390249
Intra	Lrrc7	P70587	Dlg4	Rattus norvegicus	P31016	IF	12390249
Intra	Lrrc7	P70587	Dlg4	Rattus norvegicus	P31016	Anti Bait CoIP	12390249
Cross	Lrrc7	P70587	Camk2a	Mus musculus	P11798	Filter Binding	16120608
Cross	Lrrc7	P70587	Camk2a	Mus musculus	P11798	Pull Down	16120608
Intra	Lrrc7	P70587	Cnksr2	Rattus norvegicus	Q9Z1T4	Anti Bait CoIP	12390249

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07826	LRRC7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrrc7	NCBI	NCBI:57554

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